Antiviral Drugs
Mostrando 13-24 de 298 artigos, teses e dissertações.
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13. HCMV UL97 phosphotransferase gene mutations may be associated with antiviral resistance in immunocompromised patients in Belém, PA, Northern Brazil
Abstract INTRODUCTION: Human cytomegalovirus is one of the causes of opportunist infections in immunocompromised patients, and is triggered by factors such as state of viral latency, weakened immune responses, and development of antiviral resistance to ganciclovir, the only drug offered by the public health system in Brazil to treat the infection. The goal
Rev. Soc. Bras. Med. Trop.. Publicado em: 2018-04
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14. Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol
ABSTRACT Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antib
An. Acad. Bras. Ciênc.. Publicado em: 2017-09
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15. Influence of Treg cells and HBV genotype on sustained response and drug resistance in the treatment with nucleoside drugs
We aimed to investigate the influence of regulatory T cells including CD4+CD25+, CD8+CD28- and hepatitis B virus (HBV) genotype on sustained virological response and tolerance of nucleoside drugs. One hundred and thirty-seven patients were enrolled. Lamivudine was administered to 84 patients. Entecavir was administered to the other 53 patients. Before treatm
Braz J Med Biol Res. Publicado em: 02/03/2017
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16. Antiviral activity of animal venom peptides and related compounds
Abstract Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agent
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 20/02/2017
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17. Treatment of hepatitis C virus genotype 3 infection with direct-acting antiviral agents
Hepatitis C virus (HCV) genotype 3 is responsible for 30.1% of chronic hepatitis C infection cases worldwide. In the era of direct-acting antivirals, these patients have become one of the most challenging to treat, due to fewer effective drug options, higher risk of developing cirrhosis and hepatocellular carcinoma and lower sustained virological response (S
Braz J Med Biol Res. Publicado em: 24/10/2016
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18. Natural Product-Derived Drugs Based on β-Adrenergic Agents and Nucleosides
This relatively short review demonstrates the very important role of the structures of the natural products adrenaline and relatives, in the design and subsequent approval of β-agonists and antagonists, and of modified nucleosides as anticancer, and in particular, antiviral agents against herpes (HSV), human immunodeficiency virus (HIV) and hepatitis C viru
J. Braz. Chem. Soc.. Publicado em: 2016-08
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19. Synergic effects between ocellatin-F1 and bufotenine on the inhibition of BHK-21 cellular infection by the rabies virus
Abstract Background Rabies is an incurable neglected zoonosis with worldwide distribution characterized as a lethal progressive acute encephalitis caused by a lyssavirus. Animal venoms and secretions have long been studied as new bioactive molecular sources, presenting a wide spectrum of biological effects, including new antiviral agents. Bufotenine, for i
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 31/12/2015
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20. Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have been found in community settings, in untreated individuals. T
Mem. Inst. Oswaldo Cruz. Publicado em: 27/02/2015
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21. Cytomegalovirus infection in transplant recipients
Cytomegalovirus infection is a frequent complication after transplantation. This infection occurs due to transmission from the transplanted organ, due to reactivation of latent infection, or after a primary infection in seronegative patients and can be defined as follows: latent infection, active infection, viral syndrome or invasive disease. This condition
Clinics. Publicado em: 2015
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22. Acute exacerbation of chronic hepatitis B virus infection in renal transplant patients
Introduction:There is scarce information regarding clinical evolution of HBV infection in renal transplant patients.Aims:To evaluate the prevalence of acute exacerbation in HBV-infected renal transplant patients and its association with the time after transplantation, presence of viral replication, clinical evolution, and use of antiviral prophylaxis.Materia
Braz J Infect Dis. Publicado em: 2014-12
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23. Antiviral activity of a Bacillus sp: P34 peptide against pathogenic viruses of domestic animals
P34 is an antimicrobial peptide produced by a Bacillus sp. strain isolated from the intestinal contents of a fish in the Brazilian Amazon basin with reported antibacterial activity. The aim of this work was to evaluate the peptide P34 for its in vitro antiviral properties against canine adenovirus type 2 (CAV-2), canine coronavirus (CCoV), canine distemper v
Braz. J. Microbiol.. Publicado em: 2014-09
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24. Herpes simplex virus: isolation, cytopathological characterization and antiviral sensitivity
BACKGROUND:Herpes simplex virus (HSV) infection is an endemic disease and it is estimated that 6095% of the adult population are infected with symptoms that are usually self-limiting, though they can be serious, extensive and prolonged in immunocompromised individuals, highlighted by the emergence of drug-resistant strains. The study of the wild-type HSV str
An. Bras. Dermatol.. Publicado em: 2014-06