Antineoplastic
Mostrando 25-36 de 242 artigos, teses e dissertações.
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25. Evaluation of demands of inclusion, exclusion and alteration of technologies in the Brazilian Health System submitted to the National Committee on Technology Incorporation
ABSTRACT The steady increase in the number of health technologies and advances in associated research generate management challenges in the choice of technologies to be made available to the public. From 2011, the process of inclusion, exclusion and alteration of technologies to the Brazilian Unified Health System (SUS) has undergone major transformations, s
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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26. The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB
ABSTRACT Physiological processes, as autophagy, proliferation and apoptosis are affected during carcinogenesis. Restoring cellular sensitivity to apoptotic stimuli, such as the antineoplastic cocktails, has been explored as a strategy to eliminate cancer cells. Autophagy, a physiological process of recycling organelles and macromolecules can be deviated from
An. Acad. Bras. Ciênc.. Publicado em: 2016-12
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27. Workplace Activity in Health Professionals Exposed to Chemotherapy Drugs: An Otoneurological Perspective
Abstract Introduction The manipulation of antineoplastic drugs presents high risk for accidents and occupational diseases. Objective To evaluate the auditory and vestibular systems of workers who are exposed to chemotherapeutic treatment in the University Hospital of Universidade Federal de Santa Maria, Brazil, and to identify the use of individual prote
Int. Arch. Otorhinolaryngol.. Publicado em: 2016-12
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28. Agaricus subrufescens: substratum nitrogen concentration and mycelial extraction method on antitumor activity
ABSTRACT Antitumor activity of Agaricus subrufescens has been shown on vegetative mycelium and basidiocarp. However, few studies have assessed the effect of A. subrufescens cultivation conditions and extraction methods on antitumor activity. This study evaluated the effect of nitrogen concentration on the cultivation medium of A. subrufescens and the extract
An. Acad. Bras. Ciênc.. Publicado em: 2016-12
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29. l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines
ABSTRACT BACKGROUND: Myeloproliferative neoplasms are Philadelphia chromosome-negative diseases characterized by hyperproliferation of mature myeloid cells, associated or not with the Janus kinase 2 tyrosine kinase mutation, JAK2V617F. As there is no curative therapy, researchers have been investigating new drugs to treat myeloproliferative neoplasms, incl
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-06
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30. Serious stomatitis and esophagitis: a peculiar mucous reaction induced by pegylated liposomal doxorubicin
AbstractPegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palma
An. Bras. Dermatol.. Publicado em: 2015-06
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31. Dental anomalies in children submitted to antineoplastic therapy
Cancer is the third most frequent cause of death in children in Brazil. Early diagnosis and medical advances have significantly improved treatment outcomes, which has resulted in higher survival rates and the management of late side effects has become increasingly important in caring for these patients. Dental abnormalities are commonly observed as late effe
Clinics. Publicado em: 2014-06
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32. Toxins from the Caribbean sea anemone Bunodeopsis globulifera increase cisplatin-induced cytotoxicity of lung adenocarcinoma cells
Background Lung cancer causes 1.4 million deaths worldwide while non-small-cell lung cancer (NSCLC) represents 80-85% of the cases. Cisplatin is a standard chemotherapy against this type of cancer; however, tumor cell resistance to this drug limits its efficacy. Sea anemones produce compounds with pharmacological activities that may be useful for augmenting
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 07/05/2013
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33. Atividade antinociceptiva e anti-inflamatória do sesquiterpeno nerolidol em camundongos. / Antinociceptive and anti-inflammatory activities of the sesquiterpeno nerolidol in mice.
Nerolidol, an acyclic sesquiterpene found as the major component in several essential oils, has antineoplastic, antimicrobial and antileishmanial activities, however its action in painful processes has never been studied. This study investigated the antinociceptive and anti-inflammatory activities of nerolidol in experimental pain and inflammation models in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/12/2012
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34. Estudo da atividade citotóxica do poliacetileno 5-octa-2, 4, 6-triinil-furan-2(5H)-ona / Study of the cytotoxic activity of polyacetylene 5-octa-2,4,6-triinil-furan-2 (5H)-one
Skin cancers are the most common types of cancer in Brazil, and correspond to around 25% of all malignant tumors recorded. Of these, melanoma represents at least 5% and is characterized by its high metastatic power. The development of anticancer agents from natural products is considered critical to pharmacology, and interest in the development of more effec
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/06/2012
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35. Avaliação dos Efeitos Antineoplásicos da Zebularina em Linhagens Pediátricas de Leucemia Linfoide Aguda. / Evaluation of Antineoplastic Effects of Zebularine on Childhood Acute Lymphoblastic Leukemia Cell Lines.
A leucemia linfóide aguda (LLA) é a neoplasia hematológica mais comum na infância e representa uma doença heterogênea em relação à biologia e ao prognóstico e seu tratamento consiste principalmente em quimioterapia. Apesar dos avanços no tratamento, cerca de 20% dos pacientes apresentam recaída da doença e/ou óbito indicando a necessidade de te
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/03/2012
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36. Angiogênese, células-tronco neoplásicas CD34+ e sinvastatina em modelo de carcinogênese mamária induzida quimicamente / Angiogenesis, CD34+ cancer stem-cells and simvastatin in a chemically induced mammary carcinogenesis model
Breast cancer is the most common malignancy and the leading cause of death from cancer among females worldwide. Despite all the research and all the progress achieved so far, the morbidity and mortality due to this cancer remains high in patients at advanced stages. Recently, it was described a new model of carcinogenesis in which stem cells (SC) could be re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/02/2012