Antineoplasic Activity
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Evaluation of the antioxidant potential of Copaifera multijuga in Ehrlich tumor-bearing mice
RESUMO Copaifera multijuga, ou copaíba, é utilizada popularmente como chá para o tratamento de diversas afecções, o que se deve à presença de substâncias antioxidantes em sua composição, que protegem as células contra danos causados pelos radicais livres. O óleo-resina da árvore é usado como antiinflamatório e antitumoral. O presente estudo av
Acta Amaz.. Publicado em: 2019-03
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2. Purificação, conjugação e avaliação "in vitro" da atividade antineoplásica da L-asparaginase produzida por Aspergillus terreus (cepa PC-1.7.A) / Purification, conjugation and evaluation in vitro of antineoplasic activity L-asparaginase of Aspergillus terreus (cepa PC-1.7.A)
A enzima L-asparaginase (L-asparagina amino hidrolase, E.C. 3.5.1.1) é uma das drogas mais utilizadas no tratamento da leucemia linfoblástica aguda. A enzima catalisa a hidrólise do aminoácido asparagina em ácido aspártico e amônia. Algumas linhagens de células tumorais não são capazes de produzir asparagina, dependendo do aminoácido presente no p
Publicado em: 2010
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3. Investigação da mielotoxicidade e do potencial indutor de morte celular de Synadenium umbellatum Pax. em células do tumor ascítico de Ehrlich / Investigation of myelotoxicity and potential inducer cell death of Synadenium umbellatum Pax. cell Ehrlich ascites tumor
In search of new antineoplasic agents natural products have played an important role, given that about 40% of available medicines in current treatments have been developed from natural sources, 25% approximately of plants. Synadenium umbellatum belongs to Euphorbiaceae family and is popularly known as "cola-nota", "avelós," "milagrosa", "cancerola", and the
Publicado em: 2010
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4. Antineoplasic activity of Agaricus brasiliensis basidiocarps on different maturation phases
The fungus Agaricus brasiliensis is a Basidiomycete studied because of its immunomodulation and/or antitumor substances. The objective of this study was to verify the Agaricus brasiliensis antineoplasic activity in vivo on different basidiocarp maturation phases on Sarcoma 180 cells implanted in mice. Sarcoma cells were implanted in mice and after seven days
Brazilian Journal of Microbiology. Publicado em: 2009-12
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5. Avaliação in vitro da atividade antineoplásica do ácido lecanórico e de seus produtos de modificação estrutural / Evaluation in vitro of antineoplasic activity of lecanoric acid and their products of estructural modification
Lichens are a symbiotic association of a fungus and one or more photosynthetic partners. Phenolic substances from lichens exhibit a wide range of biological actions, including antimicrobial, antineoplasic, and cytotoxic activities. The purpose of this study was evaluate in vitro the antineoplasic activity of orsellinates obtained from estructural modificatio
Publicado em: 2009
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6. Correlação entre os ensaios de citotoxicidade em Artemia salina Leach e atividade antineoplásica sobre linhagens de células tumorais para algumas classes de produtos naturais / Correlation between the citotoxicity assays in Artemia salina Leach and antineoplasic activity on tumoral cell lines for some natural products groups
The aim of this study was to correlate qualitative and quantitatively the lethal concentration needed for the citotoxic test on Artemia salina with the inhibitory concentration for the growth of tumoral cell lines using ten pure substances already known. Estimates for the year 2008 and also valid for the year 2009, in Brazil, show the occurrence of 466.730 n
Publicado em: 2009
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7. InvestigaÃÃo das propriedades farmacolÃgicas de Azadirachta indica A. Juss.
The family Meliaceae there is fifty genus that distributed in tropics already the world. Is a plant port tree, small flowers. Azadirachta indica is known populary by nim, amargosa is a plant native to Asian. Different part of this plant have been reported to possess medicinal properties like antiviral, antibacterial, antifungal, antidiabetic, anti-inflammato
Publicado em: 2008
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8. Estudos de modelagem molecular e relação estrutura atividade da oncoproteína hnRNP K e ligantes / Molecular modeling and structure activity relationship studies of the hnRNP K oncoprotein and ligands.
The Brazilian Project Genoma Câncer (PGHC) supported by FAPESP and the Ludwig Institute for Cancer Research, intended to identify the genes involved in the most common cases of cancer in Brazil. In this project about a million of gene sequences were identified. The major contribution was made in breast, colorectal and head and neck cancers. The results obta
Publicado em: 2008
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9. A importÃncia de Plectranthus amboinicus (Lour.) Spreng como alternativa terapÃutica â mÃtodos experimentais
Plectranthus amboinicus (Lour.) Spreng (Lamiaceae) à uma planta herbÃcea nativa da Ãsia Oriental e encontra-se distribuÃda por toda a AmÃrica. No Brasil, à conhecida como hortelà da folha grossa, hortelà da folha graÃda, malvariÃo e mundialmente como orÃgano, sendo utilizada popularmente como analgÃsica, antiinflamatÃria e antimicrobiana. Esta p
Publicado em: 2007
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10. Study of activity carboquinones throught quantum descriptors / Estudo da atividade antineoplasica das carboquinonas atraves de descritores quanticos
The discovery of efficient treatments against cancer is one of the great challenges of science. In Brazil the cancer became the second greatest cause of death. For the year 2005 467,440 new cases of cancer are expected. The investment for the development of a modern drug is about U$ 850 millions and the treatment with those drugs varies from U$ 4,000 to U$ 1
Publicado em: 2006
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11. Physalis angulata L. antineoplasic activity, in vitro, evaluation fromit's stems and fruit capsules
Physalis angulata L. (genus Physalis; family Solanaceae) is an herbaceous specimen that grows plentifully at North, Northeast and Middleast Brazilian's regions1. Its fruits are edible, roots and epigeal parts are taken as tea or infusion, all through the world as traditional medicine. Despite of this usefulness not much scientific work has been done on it. T
Revista Brasileira de Farmacognosia. Publicado em: 2002
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12. Citocidade de derivados de beta -enaminocetonas em celulas de mamiferos
Studies on structure-activity relationships are essential for the development of new pharmacological drugs. In this work we have investigated the cytotoxicity of new structurally related synthetic compounds, the y-aminoalcohols 2-pentanol-4 benzylamine (PBA), 2-pentanol-4-phenylamine (PPA) and the corresponding tetrahydro-I,3-oxazines, 2-pentanol-4benzyloxaz
Publicado em: 1997