Physalis angulata L. antineoplasic activity, in vitro, evaluation fromit's stems and fruit capsules

AUTOR(ES)

Ribeiro, I.M., Silva, M.T.G., Soares, R.D.A., Stutz, C.M., Bozza, M., Tomassini, T.C.B.

FONTE

Revista Brasileira de Farmacognosia

DATA DE PUBLICAÇÃO

2002

RESUMO

Physalis angulata L. (genus Physalis; family Solanaceae) is an herbaceous specimen that grows plentifully at North, Northeast and Middleast Brazilian's regions1. Its fruits are edible, roots and epigeal parts are taken as tea or infusion, all through the world as traditional medicine. Despite of this usefulness not much scientific work has been done on it. This research carried out with plant material (stems and fruit capsules) has the main aim to find out anti-neoplasic activity. The obtained results are described in Table 1. The most significant inhibition values are those for fruit capsules fractions such as 97% mouse lymphoma; 93% Erlich carcinoma strains when was assayed with MGTS-1-2ai and MGTS-1-1ai respectively. In the course on going studies on the biological response and chemical constituents of P. angulata some fractions were obtained from stems and fruit capsules ethanolic and methanolic extracts. The extract prepared from roots of P. angulata is the most clinically used by physicians for treatment of human hepatic disorders, despite the substance responsible for the efficacy still a matter of argument.

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