Antigen Presenting Cell
Mostrando 1-12 de 704 artigos, teses e dissertações.
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1. Preservation of cytotoxic granule production in response to mycobacterial antigens by T-lymphocytes from vertically HIV-infected Brazilian youth on effective combined antiretroviral therapy
ABSTRACT Background: HIV infection harms adaptive cellular immunity mechanisms. Long-term virological control by combined antiretroviral therapy (cART) reduces the risk of mycobacterial infections. Thus, we aimed to study cellular responses to mycobacterial antigens in 20 HIV-infected adolescents with at least one year of virological control (HIV-RNA <40 co
Braz J Infect Dis. Publicado em: 09/09/2019
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2. Innate immunity and HPV: friends or foes
Most human papillomavirus infections are readily cleared by the host immune response. However, in some individuals, human papillomavirus can establish a persistent infection. The persistence of high-risk human papillomavirus infection is the major risk factor for cervical cancer development. These viruses have developed mechanisms to evade the host immune sy
Clinics. Publicado em: 11/10/2018
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3. Transfusion of older red blood cell units, cytokine burst and alloimmunization: a case-control study
BACKGROUND: Experimental data have shown that the transfusion of older red blood cell units causes alloimmunization, but the clinical applicability of this statement has never been properly assessed in non-sickle cell patients. It has been hypothesized that older units have higher numbers of cytokines, increasing the risk of alloimmunization related to antig
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-10
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4. Host response mechanisms in periodontal diseases
Periodontal diseases usually refer to common inflammatory disorders known as gingivitis and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm, including Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Treponema denticola that trigger innate, inflammatory, and adaptive immune respon
J. Appl. Oral Sci.. Publicado em: 2015-06
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5. Expression of costimulatory molecules in antigen-activated peritoneal macrophages treated with either ovalbumin or palmitoyl-ova conjugates
One of the mechanisms by which adjuvants are believed to promote T-cell activation and prevent induction of oral tolerance is by up-regulating the expression of co-stimulatory molecules on antigen presenting cells. Mice treated orally with palmitoyl-ovalbumin conjugates become immunized, while those treated with native ovalbumin (Ova) become tolerant. Cells
Braz. arch. biol. technol.. Publicado em: 25/10/2013
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6. Differential expression of the costimulatory molecules CD86, CD28, CD152 and PD-1 correlates with the host-parasite outcome in leprosy
Leprosy is a spectral disease exhibiting two polar sides, namely, lepromatous leprosy (LL) characterised by impaired T-cell responses and tuberculoid leprosy in which T-cell responses are strong. Proper T-cell activation requires signalling through costimulatory molecules expressed by antigen presenting cells and their ligands on T-cells. We studied the infl
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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7. Avaliação da ativação linfócitária por diferentes combinações de células apresentadoras de antígenos. / Evaluation of lymphocyte activation by different combinations of antigen presenting cells.
Acredita-se que as células dendríticas (DCs) sejam as mais eficientes na ativação de linfócitos T (LT) naive. Com a possibilidade de geração in vitro de DCs, muitos protocolos explorando este potencial vêm sendo desenvolvidos, principalmente em abordagens imunoterapêuticas para o câncer. Todavia, em situações fisiológicas a apresentação antig�
Publicado em: 2010
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8. Susceptibilidade diferencial de células trofoblásticas humanas (BeWo) e cervicais uterinas (HeLa) à infecção por Neospora caninum
Neospora caninum is an obligate intracellular parasite, closely related to Toxoplasma gondii, and considered a major cause of abortion and congenital neosporosis in cattle worldwide. As trophoblast cells act in mechanisms of innate immune defense at fetal-maternal interface, and no data are available about the interaction of this parasite with human trophobl
Publicado em: 2010
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9. Efeito da temperatura febril sobre o fenótipo e função de células dendríticas derivadas de monócitos sangüineos. / Effect of fever-range temperature on monocyte-derived dendritic cell phenotype and function.
Dendritic cells (DCs) are the main antigen presenting cells and susceptible to many activation signals that will induce different patterns of DC activation and of T cell responses. In this work we studied the effects of two danger signals, fever and LPS, on DC phenotype and function. Exposure of immature monocyte-derived dendritic cells to heat did not affec
Publicado em: 2008
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10. Regulação do CD95L por PGE2 e seu impacto na morte de linfócitos T. / CD95L downregulation by PGE2 and its impact on T lymphocyte death.
Antigen-presenting cells (APCs) control T-cell responses by multiple mechanisms, including the expression of co-stimulatory molecules and the production of cytokines and other mediators that control T-cell proliferation, survival and differentiation. In this present work, it was demonstrated that soluble factor(s) produced by Toll-like receptor (TLR)-activat
Publicado em: 2008
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11. Análise de polimorfismo no gene CTLA-4 em pacientes com paracoccidioidomicose
The CTLA-4 protein is mainly expressed in activated T cells and plays an essential role in the immune response through its regulatory effect on T cell activation. This activity is mediated by the binding of CTLA-4 to molecules of the B7 family that are expressed by antigen-presenting cells. Polymorphisms of the CTLA-4 gene have been correlated to several aut
Publicado em: 2008
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12. Dendritic cells (DC) generation from peripheral blood mononuclear cells obtained from jaundiced patients with pancreatic adenocarcinoma. / Análise de células mononucleares mantidas em cultura em meio propício para geração de células dendríticas obtidas de pacientes com câncer de pâncreas.
Pancreatic adenocarcinoma (PAdc) is an aggressive malignancy with poor prognosis, urging for improved or new therapeutic strategies. DC-based vaccination is one of such promising approaches. DC are the most potent antigen-presenting cells and central to the induction and maintenance of an immune response. However, in cancer patients DC generation and functio
Publicado em: 2008