Analgesic Activity
Mostrando 25-36 de 154 artigos, teses e dissertações.
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25. Triterpenes from the Protium heptaphyllum resin - chemical composition and cytotoxicity
Protium heptaphyllum (Aubl) Marchand, Burseraceae, is popularly used as an analgesic and anti-inflammatory agent. However, the cellular mechanism of action remains unknown. This study aims to evaluate the chemical composition of P. heptaphyllum resin and cytotoxicity on a breast cancer cell line (MCF-7). The chemical composition of the resin was determined b
Rev. bras. farmacogn.. Publicado em: 2014-08
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26. Therapeutic concentration of morphine reduces oxidative stress in glioma cell line
Morphine is a potent analgesic opioid used extensively for pain treatment. During the last decade, global consumption grew more than 4-fold. However, molecular mechanisms elicited by morphine are not totally understood. Thus, a growing literature indicates that there are additional actions to the analgesic effect. Previous studies about morphine and oxidativ
Braz J Med Biol Res. Publicado em: 11/04/2014
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27. Extracts from the leaves of Campomanesia velutina inhibits production of LPS/INF-γ induced inflammatory mediators in J774A.1 cells and exerts anti-inflammatory and antinociceptive effects in vivo
Campomanesia velutina (Cambess) O. Berg, Myrtaceae, popularly known as "gabiroba" or "guavira", is used in traditional Brazilian medicine to treat several diseases, including inflammation and rheumatism. Extraction and isolation from leaves of the plant afforded the active compound myricetin 3-O-rhamnoside, also known as myricitrin. The ethanolic extract of
Rev. bras. farmacogn.. Publicado em: 2013-12
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28. Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract
Phyllanthus niruri L., Euphorbiaceae, spray-dried standardized extract was studied for its anti-inflammatory and antinociceptive activities in adult albino rats and mice. The anti-inflammatory effect of spray-dried standardized extract was observed in carrageenan-induced paw edema and thioglycolate-induced leukocyte migration, while antinociceptive effects w
Rev. bras. farmacogn.. Publicado em: 01/02/2013
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29. Efeitos da Acupuntura, Eletroacupuntura e Metformina Sobre o Estresse Oxidativo, InflamaÃÃo e Glicemia em Ratas Sadias Submetidas a EstÃmulo EstrogÃnico / EFFECTS OF ACUPUNCTURE, ELETROACUPUNCTURE AND METFORMIN ON OXIDATIVE STRESS, INFLAMMATION AND BLOOD GLUCOSE IN HEALTHY RATS SUBMITTED TO ESTROGENIC STIMULATION
The physiological performance of cellular activity requires a balance between the production of free radicals and their deactivation by regulators and surge protectors. When this balance is broken, the oxidative stress takes place. Several experimental studies using estrogens to induction of ovarian and metabolic disorders, with emphasis on the polycystic ov
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2012
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30. Desenvolvimento e caracterização de microemulsão à base de óleo de sucupira (P. emarginatus Vog. Fabaceae) e avaliação da atividade antiinflamatória tópica / Development and characterization of oil sucupira microemulsion (P. emarginatus Vog. Fabaceae) and evaluation of topical anti-inflammatory activity
Pterodon emarginatus, popularly known as Sucupira Branca is a native species found in the Brazilian Savannahs in states of Goiás, Minas Gerais, São Paulo, Mato Grosso do Sul. Several studies have confirmed their therapeutic activities as antiinflammatory, antinociceptive, analgesic, antimicrobial, among others. The aim of this study was to develop a microe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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31. Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida
The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4'-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectivel
Revista Brasileira de Farmacognosia. Publicado em: 09/01/2012
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32. Sertraline inhibits formalin-induced nociception and cardiovascular responses
The objective of the present study was to determine the antihyperalgesic effect of sertraline, measured indirectly by the changes of sciatic afferent nerve activity, and its effects on cardiorespiratory parameters, using the model of formalin-induced inflammatory nociception in anesthetized rats. Serum serotonin (5-HT) levels were measured in order to test t
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-01
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33. Assessment of biomedical and pharmacological activities of sea anemones Stichodactyla mertensii and Stichodactyla gigantea from Gulf of Mannar Biosphere Reserve, southeast coast of India
Cnidarians comprise an old and diverse animal phylum, and possess a wide variety of biologically active substances. Sea anemones contain a diversity of interesting biologically active compounds including some potent toxins. In the present work, the sea anemones Stichodactyla mertensii and Stichodactyla gigantea, collected from the Mandapam coast, are charact
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
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34. Modulação da atividade dos canais de sódio dependentes de voltagem e de canais TRPV1 por (-)-Carvona
Among the natural products with experimentally proven analgesic properties, the monoterpernes are of great importance, recognized as the main chemical constituents of essential oils from aromatic plants. ()-Carvone is an example of monoterpene with antinociceptive properties, founded as the main active constituent of oils from some species of the genus Menth
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/12/2011
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35. Atividade antioxidante de extratos e compostos isolados de Eugenia umbelliflora e Rapanea ferrugínea / ANTIOXIDANT ACTIVITY OF ISOLATED COMPOUNDS AND EXTRACTS OF Eugenia umbelliflora and Rapanea ferruginea
Eugenia umbeliflora is popularly known as baguaçu, guapê or guaramirim in Portuguese and Brazilian Cherry in English. This species is used in popular medicine to treat diseases such as arthritis, rheumatism and diabetes, although there have been few biological studies to verify the effectiveness of these extracts. Rapanea ferruginea is popularly known as c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/09/2011
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36. Avaliação da possível diferença na sensibilidade dolorosa de ratos machos e fêmeas e da resposta de cada sexo a crotalfina, um analgésico tipo opióide. / Sex differences in nociception and in the antinociceptive activity of crotalphine, an opioid-like analgesic drug.
Evidências clínicas e experimentais têm sugerido a existência de diferenças na sensação de dor e na resposta a fármacos analgésicos entre machos e fêmeas. A crotalfina (CRF), um peptídeo inicialmente isolado e caracterizado no veneno de serpentes Crotalus durissus terrificus, apresenta efeito antinociceptivo, quando avaliado em diferentes modelos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/08/2011