Analgesic Activity
Mostrando 13-24 de 154 artigos, teses e dissertações.
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13. Solvent extraction effects on phytochemical constituents profiles, antioxidant and antimicrobial activities and functional group analysis of Ecballium elaterium seeds and peels fruits
Abstract Ecballium elaterium is a perennial herb with multiple medicinal properties. It was widely used in folk medicine as cathartic, anti-inflammatory and analgesic agents. The present study was devoted to investigate the effect of diethyl ether, acetone, and methanol solvent on the extraction, phytochemicals profiles, antioxidant and antimicrobial activit
Food Sci. Technol. Publicado em: 27/04/2017
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14. Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae)
ABSTRACT Piperaceae species can be found worldwide in tropical and subtropical areas and many of them have been used for centuries in traditional folk medicine and in culinary. In Brazil, species of Piperaceae are commonly used in some communities as local anesthetic and analgesic. Countrified communities have known some species of the genus Ottonia as "anes
An. Acad. Bras. Ciênc.. Publicado em: 2016-12
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15. Design, Synthesis, Pharmacological Evaluation and Molecular Docking Studies of Substituted Oxadiazolyl-2-Oxoindolinylidene Propane Hydrazide Derivatives
The manuscript describes design and synthesis of novel oxadiazolyl-2-oxoindolinylidene propane hydrazides as amide tethered hybrids of indole and oxadiazole and their evaluation for anti-inflammatory and analgesic activity. The compounds were synthesized following five step reaction to yield fifteen derivatives as 3-(5-substituted-1,3,4-oxadiazol-2-yl)-N'-[2
J. Braz. Chem. Soc.. Publicado em: 2016-11
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16. Antinociceptive Effect of Essential Oils and Their Constituents: an Update Review
Plants and essential oils (EOs) have been used for centuries in folk medicine to treat diverse disorders, including analgesic to pain relief. In this context, the antinociceptive activity of EOs has been attracted attention since the management of pain continues being a major challenge for medicine. This review provides an overview of published reports on th
J. Braz. Chem. Soc.. Publicado em: 2016-03
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17. Analgesic and anti-inflammatory activities of hydro-alcoholic extract of Lavandula officinalis in mice: possible involvement of the cyclooxygenase type 1 and 2 enzymes
Abstract Lavandula officinalis Chaix, Lamiaceae, extracts can inhibit inflammation and also pain induced by formalin in mice. This study evaluated the effects of L. officinalis hydro-alcoholic extract on pain induced by formalin and also cyclooxygenase (COX) type 1 and 2 activity in mice. To evaluate probable analgesic and anti-inflammatory effects of the ex
Rev. bras. farmacogn.. Publicado em: 2016-02
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18. Essential oil of Lippia alba and its main constituent citral block the excitability of rat sciatic nerves
Lippia alba is empirically used for infusions, teas, macerates, and hydroalcoholic extracts because of its antispasmodic, analgesic, sedative, and anxiolytic effects. Citral is a mixture of trans-geranial and cis-neral and is the main constituent of L. alba essential oil and possesses analgesic, anxiolytic, anticonvulsant, and sedative effects. The present s
Braz J Med Biol Res. Publicado em: 30/06/2015
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19. Recent Syntheses of Frog Alkaloid Epibatidine
Many natives from Amazon use poison secreted by the skin of some colorful frogs (Dendrobatidae) on the tips of their arrows to hunt. This habit has generated interest in the isolation of these toxins. Among the over 500 isolated alkaloids, the most important is undoubtedly (-)-epibatidine. First isolated in 1992, by Daly from Epipedobates tricolor, this comp
J. Braz. Chem. Soc.. Publicado em: 2015-05
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20. Essential oil from Ageratum fastigiatum reduces expression of the pro-inflammatory cytokine tumor necrosis factor-alpha in peripheral blood leukocytes subjected to in vitro stimulation with phorbol myristate acetate
Abstract Ageratum fastigiatum (Gardner) R.M. King & H. Rob., a member of the Asteraceae family popularly known in Brazil as "matapasto", is indicated in folk medicine as anti-inflammatory and analgesic. Despite its popular use, little is known about its potential effect on the parameters involved in an inflammatory response. The objective of this study was t
Rev. bras. farmacogn.. Publicado em: 2015-04
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21. Analgesic effect of Hypericum perforatum, Valeriana officinalis and Piper methysticum for orofacial pain
AIM: To evaluate in vivo the association of hypericum Hypericum perforatum, valerian Valeriana officinalis and kava Piper methysticum with analgesia by assessing their effects in reducing orofacial pain as well as the possible hepatic, hematologic and biochemical alterations induced by regular administration of these extracts. METHODS: Orofacial pain was in
Braz. J. Oral Sci.. Publicado em: 2015-03
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22. The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2
It is currently accepted that superoxide anion (O2•−) is an important mediator in pain and inflammation. The role of superoxide anion in pain and inflammation has been mainly determined indirectly by modulating its production and inactivation. Direct evidence using potassium superoxide (KO2), a superoxide anion donor, demonstrated that it induced thermal
Braz J Med Biol Res. Publicado em: 13/02/2015
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23. Seasonal Effects on HPLC-DAD-UV and UPLC-ESI-MS Fingerprints and Analgesic Activities of Vernonia Condensata Baker Extracts
Vernonia condensata Baker leaves have different uses in Brazilian folk medicine, including as analgesic and anti-inflammatory agents. The purpose of this study was to evaluate the seasonal effects on their high performance liquid chromatography with a diode array detector (HPLC-DAD-UV) and ultra-performance liquid chromatography coupled to a mass spectromete
J. Braz. Chem. Soc.. Publicado em: 2015-02
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24. Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice
The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to a suspension of the pure DMA. Solid complexes prepared by different methods were evaluated in pharmacodynamics and pharmacokinetics studies. The
Braz. arch. biol. technol.. Publicado em: 2014-12