Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract
AUTOR(ES)
Porto, Cínthia R. C., Soares, Luiz A. L., Souza, Tatiane P., Petrovick, Pedro R., Lyra, Ibson L., Araújo Júnior, Raimundo F., Langassner, Silvana Maria Zucolotto, Ferreira, Aurigena A. A., Guerra, Gerlane C. B.
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
01/02/2013
RESUMO
Phyllanthus niruri L., Euphorbiaceae, spray-dried standardized extract was studied for its anti-inflammatory and antinociceptive activities in adult albino rats and mice. The anti-inflammatory effect of spray-dried standardized extract was observed in carrageenan-induced paw edema and thioglycolate-induced leukocyte migration, while antinociceptive effects were observed using Randall & Selitto, tail flick, and hot plate tests. This study showed that intraperitoneal spray-dried standardized extract at 100, 200, 800, or 1600 mg/kg reduced the vascular response in the inflammatory process of paw edema induced by 1% carrageenan. Oral spray-dried standardized extract at 100 or 200 mg/kg inhibited leukocyte migration to the site of inflammation induced by 3% thioglycolate. In rats, at 100 and 200 mg/kg intraperitoneally, the extract exhibited a marked peripheral analgesic effect in a Randall & Selitto assay and showed significant central analgesic activity in a hot plate and tail flick assay. In conclusion, this study suggested that Phyllanthus niruri spray-dried standardized extract has potent inflammatory and antinociceptive activities and that these activities are not modified by standard drying process, making it feasible to use the dry extract standardized to obtain a phytotherapic preparation and thus validating its use for the treatment of pain and inflammation disorders.
Documentos Relacionados
- Development of granules from Phyllanthus niruri spray-dried extract
- Eudragit E as excipient for production of granules and tablets from phyllanthus niruri L spray-dried extract
- Antinociceptive and anti-inflammatory activities of ethanolic extract of Alafia barteri
- Antinociceptive and anti-inflammatory activities of an aqueous extract of Chiliotrichum diffusum
- Anti-inflammatory and antinociceptive activities of methanolic extract from red seaweed Dichotomaria obtusata