Aminotriazole
Mostrando 13-24 de 49 artigos, teses e dissertações.
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13. Nutritional Studies of Rickettsia quintana: Nature of the Hematin Requirement
Rickettsia quintana grew in a liquid medium consisting of a brain-heart infusion base supplemented with starch and hematin. The growth requirement for hematin could not be substituted by compounds of known catalytic activity for H2O2, viz., catalase, potassium pyruvate, or charcoal, or by the reducing compounds sodium sulfite and sodium thioglycollate. R. qu
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14. Studies on the Mode of Action of Aminotriazole in the Induction of Chlorosis
The herbicide 3-amino-1, 2, 4-triazole induces complete chlorosis without any morphogenetic effect on Canna edulis leaves. Comparative analyses of the mineral and biochemical composition and also of the physiological properties of normal and bleached leaf cells establish a high specificity of this herbicide for inhibition of formation of chloroplast membrane
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15. Catalase-Aminotriazole Method for Measuring Secretion of Hydrogen Peroxide by Microorganisms
A new method for measuring the secretion of H2O2 has been based upon an H2O2-dependent inhibition of catalase by 3-amino-1,2,4-triazole. The conversion of an H2O2-secretion rate into a catalase inhibition rate amplified a relatively small molar concentration of H2O2 and provided a highly specific and sensitive method for quantitatively measuring H2O2. A majo
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16. In vivo formation of H2O2 in red cells during exposure to hyperoxia
Chow-fed and tocopherol-deficient mice were given aminotriazole (AT), exposed to 100% O2 at 60 pounds per square inch absolute for 1 hr (OHP), and red blood cells were assayed for catalase activity and lipid peroxide levels. A decrease of catalase activity (CA) in the presence of AT can be taken as evidence of excess formation or accumulation of H2O2. No dif
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17. Sequence and transcriptional analysis of the Streptomyces glaucescens tcmAR tetracenomycin C resistance and repressor gene loci.
Sequence analysis of the tcmA tetracenomycin C resistance gene from Streptomyces glaucescens GLA.O (ETH 22794) identifies one large open reading frame whose deduced product has sequence similarity to the mmr methylenomycin resistance gene from Streptomyces coelicolor, the Streptomyces rimosus tet347 (otrB) tetracycline resistance gene, and the atr1 aminotria
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18. Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts.
Hearts isolated from rats pretreated 24 hr before with endotoxin had increased myocardial catalase activity, but the same superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase activities, as hearts from untreated rats. Hearts isolated from rats pretreated with endotoxin 24 hr before also had increased myoc
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19. Derepression and repression of the histidine operon: role of the feedback site of the first enzyme.
Thiazolealanine, a false feedback inhibitor, causes transient repression of the his operon previously derepressed by a severe histidine limitation in strains with a wild-type or feedback-hypersensitive first enzyme but not in feedback-resistant mutants. Since experiments reported here clearly demonstrate that thiazolealanine is not transferred to tRNAHis, it
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20. Role of the Phagocyte in Host-Parasite Interactions XII. Hydrogen Peroxide-Myeloperoxidase Bactericidal System in the Phagocyte
An antimicrobial system in polymorphonuclear neutrophils (PMN) consisting of myeloperoxidase and hydrogen peroxide has been proposed. This system appears to be activated during phagocytosis as a result of the stimulated metabolic activities. A lysed-granules (LG) fraction was prepared from guinea pig exudative PMN. LG alone possessed bactericidal activity wh
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21. Specific regulatory interconnection between the leucine and histidine pathways of Neurospora crassa.
Leucine auxotrophs of Neurospora fall into two discrete categories with respect to sensitivity to the herbicide, 3-amino-1,2,4-triazole. The pattern of resistance corresponds exactly to the ability to produce the leucine pathway control elements, alpha-isopropylmalate and the leu-3 product. An analysis of the regulatory response of the production of enzymes
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22. Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans
Candida albicans is a major fungal pathogen of humans. It regulates its morphology in response to various environmental signals, but many of these signals are poorly defined. We show that amino acid starvation induces filamentous growth in C.albicans. Also, starvation for a single amino acid (histidine) induces CaHIS4, CaHIS7, CaARO4, CaLYS1 and CaLYS2 gene
Oxford University Press.
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23. Spontaneous oxygen radical generation by sickle erythrocytes.
Since the various membrane abnormalities of sickle erythrocytes might result from excessive accumulation of oxidant damage, we have measured the generation of superoxide, peroxide, and hydroxyl radical by normal and sickle erythrocytes using assays involving reduction of cytochrome c, aminotriazole inhibition of catalase, and methane evolution from dimethyl
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24. The fungicidal mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperoxidase-independent candidacidal mechanisms.
We tested the ability of human peripheral blood monocytes to kill Candida albicans and Candida parapsilosis. Evidence that multiple fungicidal mechanisms operate in normla monocytes was found. Normal monocytes ingested and killed viable C. albicans, and could iodinate heat-killed C. albicans. Both functions were defective in monocytes from subjects with myel