Adaptive Memory
Mostrando 25-36 de 54 artigos, teses e dissertações.
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25. Misattribution, false recognition and the sins of memory.
Memory is sometimes a troublemaker. Schacter has classified memory's transgressions into seven fundamental 'sins': transience, absent-mindedness, blocking, misattribution, suggestibility, bias and persistence. This paper focuses on one memory sin, misattribution, that is implicated in false or illusory recognition of episodes that never occurred. We present
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26. Humoral response to herpes simplex virus is complement-dependent
The complement system represents a cascade of serum proteins, which provide a major effector function in innate immunity. Recent studies have revealed that complement links innate and adaptive immunity via complement receptors CD21/CD35 in that it enhances the B cell memory response to noninfectious protein antigens introduced i.v. To examine the import
The National Academy of Sciences.
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27. Memory reconsolidation for natural language processing
We propose a model of memory reconsolidation that can output new sentences with additional meaning after refining information from input sentences and integrating them with related prior experience. Our model uses available technology to first disambiguate the meanings of words and extracts information from the sentences into a structure that is an extension
Springer Netherlands.
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28. IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44hiCD8 memory T cells, and γδ T cells. Additionally, we observed the emergence of a novel type of NK-T cells with CD8αα′ expression. Due to the expansion and activation of
The National Academy of Sciences.
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29. Predicting not to predict too much: how the cellular machinery of memory anticipates the uncertain future
Although the faculty of memory holds information about the past, it is mostly about the present and the future, because it permits adaptive responses to ongoing events as well as to events yet to come. Since many elements in the future are uncertain, the plasticity machinery that encodes memories in the brain has to operate under the assumption that stored i
The Royal Society.
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30. T cell immunity using transgenic B lymphocytes
Adaptive immunity exists in all vertebrates and plays a defense role against microbial pathogens and tumors. T cell responses begin when precursor T cells recognize antigen on specialized antigen-presenting cells and differentiate into effector cells. Currently, dendritic cells are considered the only cells capable of stimulating T lymphocytes. Here, we show
National Academy of Sciences.
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31. Persistence of Motor Memories Reflects Statistics of the Learning Event
Learning to control a new tool (i.e., a novel environment) produces an internal model, i.e., a motor memory that allows the brain to implicitly predict the behavior of the tool. Data from a wide array of experiments suggest that formation of motor memory is not a single process, but one that is due to multiple adaptive processes with different time constants
American Physiological Society.
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32. The Role of Alpha/Beta and Gamma Interferons in Development of Immunity to Influenza A Virus in Mice
During influenza virus infection innate and adaptive immune defenses are activated to eliminate the virus and thereby bring about recovery from illness. Both arms of the adaptive immune system, antibody neutralization of free virus and termination of intracellular virus replication by antiviral cytotoxic T cells (CTLs), play pivotal roles in virus eliminatio
American Society for Microbiology.
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33. Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses.
A major challenge for immunologists is to explain how the immune system adjusts its responses to the microenvironmental context in which antigens are recognized. We propose that lymphocytes achieve this by tuning and updating their responsiveness to recurrent signals. In particular, cellular anergy in vivo is a dynamic state in which the threshold for a ster
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34. Complex Effects of NMDA Receptor Antagonist APV in the Basolateral Amygdala on Acquisition of Two-Way Avoidance Reaction and Long-Term Fear Memory
Although much has been learned about the role of the amygdala in Pavlovian fear conditioning, relatively little is known about an involvement of this structure in more complex aversive learning, such as acquisition of an active avoidance reaction. In the present study, rats with a pretraining injection of the N-methyl-D-aspartate (NMDA) receptor antagoni
Cold Spring Harbor Laboratory Press.
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35. Chemokine Receptor 5 Is Dispensable for Innate and Adaptive Immune Responses to Listeria monocytogenes Infection
Chemokine receptor 5 (CCR5) binds macrophage inflammatory protein 1α (MIP-1α), MIP-1β, RANTES, and members of the monocyte chemotactic protein family and is also a receptor for human immunodeficiency virus (HIV). CCR5 ligands can suppress HIV-1 entry into cells. In humans, homozygous mutations of the ccr5 gene confer resistance to HIV-1 infection. The rol
American Society for Microbiology.
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36. Codelivery of CCR7 Ligands as Molecular Adjuvants Enhances the Protective Immune Response against Herpes Simplex Virus Type 1
Humoral and cellular immunity, associated with long-term protective immunological memory, defines the efficacy of a given vaccine formulation. However, few vaccines achieve this target without the aid of a suitable adjuvant. Molecular adjuvants in vaccination against infectious agents offer a noninvasive means of enhancing the immune response against target
American Society for Microbiology.