T cell immunity using transgenic B lymphocytes
AUTOR(ES)
Gerloni, Mara
FONTE
National Academy of Sciences
RESUMO
Adaptive immunity exists in all vertebrates and plays a defense role against microbial pathogens and tumors. T cell responses begin when precursor T cells recognize antigen on specialized antigen-presenting cells and differentiate into effector cells. Currently, dendritic cells are considered the only cells capable of stimulating T lymphocytes. Here, we show that mature naïve B lymphocytes can be genetically programmed by using nonviral DNA and turned into powerful antigen-presenting cells with a dual capacity of synthesis and presentation of antigen to T cells in vivo. A single i.v. injection of transgenic lymphocytes activates T cell responses reproducibly and specifically even at very low cell doses (≈102). We also demonstrate that T cell priming can occur in the absence of dendritic cells and results in immunological memory with protective effector functions. These findings disclose aspects in the regulation of adaptive immunity and indicate possibilities for vaccination against viruses and cancer in humans.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=374340Documentos Relacionados
- APRIL modulates B and T cell immunity
- Cell-mediated immunity against herpes simplex induction of cytotoxic T lymphocytes.
- Adoptive transfer of immunity to Plasmodium berghei with immune T and B lymphocytes.
- Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.
- B Cell Differentiation and Immunoregulatory T Cell Function in Human Cord Blood Lymphocytes