IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
AUTOR(ES)
Marks-Konczalik, Joanna
FONTE
The National Academy of Sciences
RESUMO
A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44hiCD8 memory T cells, and γδ T cells. Additionally, we observed the emergence of a novel type of NK-T cells with CD8αα′ expression. Due to the expansion and activation of NK cells, the IL-15Tg mouse showed enhanced innate immunity. In adaptive T cell immunity, the roles of IL-15 contrasted with those of IL-2. IL-15 inhibited IL-2-induced T cell death, which plays a role in the maintenance of peripheral self-tolerance. IL-15 thus seems to contribute to enhanced immune memory by selectively propagating memory T cells and by blocking T cell death mediated by IL-2.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17219Documentos Relacionados
- Proteasome regulation of activation-induced T cell death
- Activation-induced T-cell death is cell cycle dependent and regulated by cyclin B.
- Ouabain exacerbates activation-induced cell death in human peripheral blood lymphocytes
- Differential ability of T cell subsets to undergo activation-induced cell death
- FK506 augments activation-induced programmed cell death of T lymphocytes in vivo.
