1 3 4 Oxadiazole
Mostrando 13-24 de 30 artigos, teses e dissertações.
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13. Síntese e modificações de derivados heterocíclicos de D-arabinose: potenciais inibidores de glicose-6-fosfato isomerase e de glicosamina-6-fosfato sintase
The synthesis of -5-(D-arabino-1,2,3,4-tetrahydroxybutyl)tetrazole and -2-(D-arabino-1,2,3,4-tetra-acetoxybutyl)-5-methyl-1,3,4-oxadiazole from D-arabinose is described. Attempts at removing the protecting groups of the oxadiazole derivative were unsuccessful, leading to products resulting from the opening of the oxadiazole ring. The unprotected tetrazole de
Química Nova. Publicado em: 2008
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14. 5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol on gold: SAM Formation and electroactivity
O composto 5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol (Hpyt) adsorve espontaneamente sobre ouro formando SAMs ("Self-Assembled Monolayers") que, de acordo com os resultados eletroquímicos e de STM ("Scanning Tunneling Microscopy"), contêm poros através dos quais as moléculas dos complexos [Fe(CN)6]4- e [Ru(NH3)6]3+ acessam a superfície livre de modificaç
Journal of the Brazilian Chemical Society. Publicado em: 2008
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15. SÃntese e propriedades fotofÃsicas de novos cristais lÃquidos luminescentes contendo os heterociclos 1,2,4-e/ou 1,3,4-oxadiazÃis
Neste trabalho nÃs descrevemos a sÃntese, comportamento tÃrmico e estudos Ãticos de trÃs sÃries de cristais lÃquidos luminescentes contendo os anÃis 1,2,4 e/ou 1,3,4-oxadiazÃis. Uma sÃrie de seis cristais lÃquidos (CL) em forma de bastÃo de hockey contendo o anel 1,2,4-oxadiazol foi obtida seguindo uma estratÃgia sintÃtica convergente. A etapa
Publicado em: 2008
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16. Synthesis and antimicrobial activity evaluation of 5-methylsulphonyl-2-tiophylidenics derivatives and 5(6)-benzofuroxanics derivatives against standard and multi-drug resistant Staphylococcus aureus strains / Síntese e avaliação da atividade antibacteriana de derivados 5-metilsulfonil-2-tiofilidênicos e de derivados 5(6)-benzofuroxânicos frente a cepas padrão e multi-resistente de Staphylococcus aureus
Emergent antimicrobial resistance is a challenge for microbiologists, physicians, public health organizations, and pharmaceutical industry. Over the past three decades Gram-positive pathogens, most notably Staphylococcus aureus, have become increasingly resistant to multiple antibiotics due to their extensive hospital and community use. This has come at time
Publicado em: 2007
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17. $a Síntese de derivados da D-arabinose e investigação da sua atividade antifúngica
The glucosamine-6-phosphate synthase is the enzyme that catalyses the conversion of D-frutose-6-phosphate to D-glucosamine-6-phosphate. This is the first step in the biochemical pathway leading to the formation of an activated form of N-acetyl-Dglucosamine, namely uridine 5-diphospho-N-acetyl-D-glucosamine. This nucleoside provides N-acetyl-D-glucosamine for
Publicado em: 2007
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18. Atividade bactericida da Ã-lapachona, isoniazida, de um derivado 1,2,4-oxadiazol-hidrazida e de suas associaÃÃes frente ao Mycobacterium fortuitum e Mycobacterium smegmatis
Nontuberculous mycobacteria are ubiquitous and saprophytic organisms that have been implicated in a large spectrum of diseases due to immunocompromised patients. Indeed, the emergence of multidrug-resistant strains and the natural resistance of atypical mycobacteria to the classical antituberculous drugs have encouraged researches in order to obtain new chem
Publicado em: 2005
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19. Eucalyptus ESTs corresponding to the protoporphyrinogen IX oxidase enzyme related to the synthesis of heme, chlorophyll, and to the action of herbicides
This work was aimed at locating Eucalyptus ESTs corresponding to the PROTOX or PPO enzyme (Protoporphyrinogen IX oxidase, E.C. 1.3.3.4) directly related to resistance to herbicides that promote oxidative stress, changing the functionality of this enzyme. PROTOX, which is the site of action of diphenyl-ether (oxyfluorfen, lactofen, fomesafen), oxadiazole (oxa
Genetics and Molecular Biology. Publicado em: 2005
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20. Mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives: use of deuterated analogues in fragmentation pattern studies
Reportamos neste trabalho o estudo sistemático de fragmentação dos derivados de N-óxidos de 1,2,5-oxadiazóis por espectroscopia de massa, usando análogos marcados com deutério para identificar algumas fragmentações críticas. Foi confirmada a perda neutra de CH2O a partir do N2-óxido de 3-hidroximetil-4-fenil-1,2,5-oxidiazol, usando o análogo mono
Journal of the Brazilian Chemical Society. Publicado em: 2004-04
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21. Efeito pÃs-antibiÃticos de um novo derivado 1,2,4-oxadiazol-hidrazida e suas associaÃÃes frente ao Mycobacterium fortuitum e Mycobacterium smegmatis
The frequent resistance of atypical micobacteria for antituberculous drugs, the absence of efficient therapeutical scheme and the studies about applications of new molecules against micobactÃrias induced us to determinate the postantibiotic effect (PAE) in vitro of a new derivative 1,2,4-oxadiazole-hidrazide (HHBA) and its associations with ofloxacin (OFLO)
Publicado em: 2004
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22. Fentolamina: aspectos farmacocinéticos e farmacodinâmica no corpo carvenoso humano / Phentolamine: pharmacokinetic aspects and pharmacodynamics in human corpus cavernosum. In vivo and in vitro study
Disfunção erétil (DE) é definida como uma inabilidade para conseguir e manter uma ereção para satisfação sexual. A fentolamina um antagonista a-adrenérgico tem sido usado para tratar DE desde 1994, principalmente em combinação com outros agentes vasoativos. Mais recentemente uma formulação oral mesilato de fentolamina foi desenvolvida para a doe
Publicado em: 2003
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23. New Antimicrobial Nitrofuran, trans-5-Amino-3-[2-(5-Nitro-2-Furyl)Vinyl]-Δ2 -1,2,4-Oxadiazole: Antibacterial, Antifungal, and Antiprotozoal Activities In Vitro
trans-5-amino-3-[2-(5-nitro-2-furyl)vinyl]-Δ2 -1,2,4-oxadiazole, a new antimicrobial nitrofuran, has shown microbial activity in vitro against a wide range of bacteria and fungi, and against several protozoa. The antimicrobial activity of the nitrofuran is not significantly diminished in vitro in the presence of 50% human serum. The compound is not cross-re
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24. Defense gene induction in tobacco by nitric oxide, cyclic GMP, and cyclic ADP-ribose
Reactive oxygen species are believed to perform multiple roles during plant defense responses to microbial attack, acting in the initial defense and possibly as cellular signaling molecules. In animals, nitric oxide (NO) is an important redox-active signaling molecule. Here we show that infection of resistant, but not susceptible, tobacco with tobacco mosaic
The National Academy of Sciences.