Ktx
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Secondary hemophagocytic syndrome after renal transplantation: two case-reports
RESUMO A síndrome hemofagocítica (SHF) ou linfo-histiocitose hemofagocítica é uma condição infrequente e subdiagnosticada que tem por base a ativação excessiva da resposta imune, resultando em fagocitose das células do sangue. Após o transplante renal (TxR), a SHF é habitualmente secundária (ou reativa) a processos infecciosos e neoplásicos, cul
J. Bras. Nefrol.. Publicado em: 18/07/2019
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2. Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
Abstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-depe
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 15/04/2019
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3. Partial purification and functional characterization of Ts19 Frag-I, a novel toxin from Tityus serrulatus scorpion venom
Abstract Background The yellow scorpion Tityus serrulatus (Ts) is responsible for the highest number of accidents and the most severe scorpion envenoming in Brazil. Although its venom has been studied since the 1950s, it presents a number of orphan peptides that have not been studied so far. The objective of our research was to isolate and identify the com
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 31/12/2015
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4. Novo método de fracionamento da peçonha do escorpião Tityus serrulatus e caracterização eletrofisiológica das toxinas Ts6 e Ts7 / New fractionation procedure of Tityus serrulatus venom and electrophysiological characterization of toxins Ts6 and Ts7
In Brazil, Tityus serrulatus (Ts) species is the responsible for the most scorpion accidents and also for the major incidence of accidents caused by venomous animals. About 16 different toxins of Ts venom have been listed so far, being Ts1 the major one. Among these toxins, the neurotoxins with action on sodium and potassium channels are the most interest in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/06/2012
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5. Isolation and structural and functional characterization of Ts15, a new neurotoxin from the venom of the scorpion Tityus serrulatus / Isolamento e caracterização estrutural e funcional da Ts15, uma nova neurotoxina da peçonha do escorpião Tityus serrulatus
Os escorpiões são um dos grupos de animais mais antigos da Terra. Eles são artrópodes e pertecem a classe Arachinida e Ordem Scorpionida. A família Buthidae compreende as espécies responsáveis pelos acidentes graves em humanos, incluindo a espécie Tityus serrulatus, o maior responsável por esses acidentes no Brasil. A peçonha do T. serrulatus cont�
Publicado em: 2010
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6. Caracterização química e atividade biológica de peptídeos presentes na peçonha do escorpião brasileiro Opisthacanthus cayaporum
Scorpions venom is a rich source of molecules with variable functions. The most studied are those that act on ion channels, particularly those selective for Na + and K +, which are responsible for the cell excitability. Besides these compounds, a family of peptides without disulfide bridges, called NDBP (Non Dissulfide Brigded Peptides), which act as pores f
Publicado em: 2009
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7. Análise proteômica parcial da peçonha do escorpião colombiano Centruroides margaritatus (Gervais, 1841)
Scorpion venoms are a complex mixture of peptides that exert their action via ion-channel modulation in biological membranes. The central objective of this project was to perform the proteomic characterization of the venom from the Colombian scorpion Centruroides margaritatus. This species is capable of producing moderate accidents and serious complications
Publicado em: 2008
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8. Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus
Uma nova toxina denominada CllErg1 (nomenclatura sistemática gama-KTx1.5) foi purificada do veneno do escorpião Centruroides limpidus limpidus e a sua seqüência de amino ácidos foi determinada. Ela tem 42 resíduos de amino ácidos entrecruzados por quatro pontes de disulfetos e bloqueia especificamente um canal de potássio da família eter-a-go-go (ER
Journal of the Brazilian Chemical Society. Publicado em: 2005-06
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9. Cloning and Expression of Genes Required for Coronamic Acid (2-Ethyl-1-Aminocyclopropane 1-Carboxylic Acid), an Intermediate in the Biosynthesis of the Phytotoxin Coronatine
Coronamic acid (CMA; 2-ethyl-1-aminocyclopropane 1-carboxylic acid) is an intermediate in the biosynthesis of coronatine (COR), a chlorosis-inducing phytotoxin produced by Pseudomonas syringae pv. glycinea PG4180. Tn5 mutagenesis and substrate feeding studies were previously used to characterize regions of the COR biosynthetic gene cluster required for synth
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10. Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients.
In order to assess the combined and separate effects of pancreas and kidney transplant on whole-body protein metabolism, 9 insulin-dependent diabetic-uremic patients (IDDUP), 14 patients after combined kidney-pancreas transplantation (KP-Tx), and 6 insulin-dependent diabetic patients with isolated kidney transplant (K-Tx), were studied in the basal postabsor