Caracterização química e atividade biológica de peptídeos presentes na peçonha do escorpião brasileiro Opisthacanthus cayaporum

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Scorpions venom is a rich source of molecules with variable functions. The most studied are those that act on ion channels, particularly those selective for Na + and K +, which are responsible for the cell excitability. Besides these compounds, a family of peptides without disulfide bridges, called NDBP (Non Dissulfide Brigded Peptides), which act as pores formers in membranes, holding antimicrobial and cytolytic activities, and as bradykinin potentiators. This study demonstrates the richness of molecules present in the venom of Brazilian scorpion Opisthacanthus cayaporum. The characterization of a K +-channel blocker, for member of the family of κ-KTx, and systematically called here as κ-KTx2.5, showed that this molecule form α-helix in an hydrophilic environment, and is able to blockhKV1.1 and 1.4 K+-channel subtypes. The partial sequence of a molecule belonging to the Escorpine family and a NDBP are also described in the work.

ASSUNTO(S)

kappa ktx ciencias da saude canal de potássio opisthacanthus cayaporum peçonha de escorpião peptídeos anti microbianos

ACESSO AO ARTIGO

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