Xenobiotics Metabolism
Mostrando 1-12 de 44 artigos, teses e dissertações.
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1. Comparing the effects of vitamin E tocotrienol-rich fraction supplementation and α-tocopherol supplementation on gene expression in healthy older adults
OBJECTIVES This study aims to compare the differential gene expression resulting from tocotrienol-rich fraction and α-tocopherol supplementation in healthy older adults. METHODS A total of 71 eligible subjects aged 50 to 55 years from Gombak and Kuala Lumpur, Malaysia, were divided into three groups and supplemented with placebo (n=23), α-tocopherol (n
Clinics. Publicado em: 11/03/2019
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2. Factors that alter the biochemical biomarkers of environmental contamination in Chironomus sancticaroli (Diptera, Chironomidae)
ABSTRACT Changes in physiology of the nervous system and metabolism can be detected through the activity of acetylcholinesterase (AChE), alpha esterase (EST-a) and beta esterase (EST-ß) in chironomids exposed to pollutants. However, to understand the real effect of xenobiotics on organisms, it is important to investigate how certain factors can interfere wi
Rev. Bras. entomol.. Publicado em: 2016-12
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3. Maternal protein restriction during lactation modulated the expression and activity of rat offspring hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2, and CYP2E1 during development
Early nutrition plays a long-term role in the predisposition to chronic diseases and influences the metabolism of several drugs. This may happen through cytochromes P450 (CYPs) regulation, which are the main enzymes responsible for the metabolism of xenobiotics. Here, we analyzed the effects of maternal protein restriction (MPR) on the expression and activit
Braz J Med Biol Res. Publicado em: 03/11/2016
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4. Fontes, formação, reatividade e determinação de quinonas na atmosfera
Quinones are a group of semi-volatile organic substances, ubiquitous in nature, belonging to the class of oxygenated polycyclic aromatic hydrocarbons (Oxygenated PAH). These compounds are formed in biogenic processes, through the oxidative metabolism of endogenous compounds, such as catecholamines, estrogen hormones and xenobiotics, as well as directly emitt
Quím. Nova. Publicado em: 2016-05
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5. Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis
Gastric cancer is one of the most common and lethal cancers worldwide. However, despite its clinical importance, the regulatory mechanisms involved in the aggressiveness of this cancer are still poorly understood. A better understanding of the biology, genetics and molecular mechanisms of gastric cancer would be useful in developing novel targeted approaches
Genetics and Molecular Biology. Publicado em: 13/07/2012
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6. Influência da variabilidade genética sobre biomarcadores de dano oxidativo e não oxidativo em pacientes com doença pulmonar obstrutiva crônica (DPOC)
Chronic Obstructive Pulmonary Disease (COPD) is a slowly progressive condition of poor reversibility that is characterized by airflow limitation associated with an abnormal inflammatory response of the lungs. Its development and progression are related to increased oxidative stress, which is an important pathogenic component of airway inflammation in this di
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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7. Modulação da atividade das enzimas de biotransformação de xenobióticos na malária murina letal e não-letal. / Modulation of the activity of enzymes of biotransformation of xenobiotics in the lethal and not-lethal murina malaria.
Durante as últimas três décadas, um expressivo número de estudos experimentais e clínicos mostrou que várias infecções e inflamações assépticas modulam a expressão e a atividade de enzimas citocromo P450 (CYP). Nesta linha de investigação, alguns estudos sugeriram que as atividades de CYP e a cinética de xenobióticos são alteradas também na
Publicado em: 2008
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8. Estudo da resposta antioxidativa de linhagens bacterianas na presença do herbicida Acetochlor / Study of the response antioxidative of bacterial strains in the presence of herbicide Acetochlor
Currently there is a great concern with respect to short and long term effects that many herbicides may cause on public health and the environment. They may seriously damage the cellular metabolism, generally leading to inhibition of the microbial growth. With the exposure to herbicides, these microorganisms significantly increase the generation of EAOs (Act
Publicado em: 2008
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9. Effect of piperine on experimental intoxication by aflatoxinas in rats. / Ação da piperina sobre a intoxicação experimental de ratos por aflatoxinas.
Piperine (1- piperoyl piperidine) main black pepper (Pipper nigrum Linn.) and long pepper (Piper longum Linn.) alkaloid presents several pharmacological and biochemical effects as enzymes inhibition from hepatic metabolism interfering on xenobiotics and pro-carcinogenic substances biotransformation activated by P-450 cytochromo cycle. According to the scient
Publicado em: 2007
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10. CYP2A6 and CYP2E1 polymorphisms in a Brazilian population living in Rio de Janeiro
Cytochrome P450 (CYP) is a superfamily of enzymes involved in the metabolism of endogenous compounds and xenobiotics. CYP2A6 catalyzes the oxidation of nicotine and the activation of carcinogens such as aflatoxin B1 and nitrosamines. CYP2E1 metabolizes ethanol and other low-molecular weight compounds and can also activate nitrosamines. The CYP2A6 and CYP2E1
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-02
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11. Alterações morfofuncionais e metabólicas no teleósteo de água doce matrinxã, Brycon cephalus (Günther, 1869) exposto ao organofosforado metil paration (Folisuper 600BR).
The xenobiotics influxes into the aquatic systems are continuous increasing in Brazil due to their use in the agriculture and to control insects in aquaculture. In the present study was evaluated if the exposure of the freshwater teleost fish matrinxã (Brycon cephalus) to sublethal concentration of the organophosphorus pesticides methylparathion (MP) induce
Publicado em: 2006
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12. Study of CYP3A5 gene expression and polymorphisms in hypercholesterolemic individuals treated with atorvastatin / Estudo da expressão gênica e de polimorfismos da CYP3A5 em pacientes com hipercolesterolemia tratados com atorvastatina
The cytochrome P450 isoenzyme 3A5 (CYP3A5) has an important role on biotransformation of endogenous compounds and xenobiotics. Single nucleotide polymorphisms (SNPs) of the CYP3A5 gene have been associated with variations on gene expression and enzyme activity that can modify the metabolism of several drugs. In order to evaluate the influence of CYP3A5 SNPs
Publicado em: 2006