Xenobiotic Metabolism
Mostrando 1-12 de 68 artigos, teses e dissertações.
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1. Detection of carboxylesterase and esterase activity in culturable gut bacterial flora isolated from diamondback moth, Plutella xylostella (Linnaeus), from India and its possible role in indoxacarb degradation
Abstract Diamondback moth (DBM), Plutella xylostella (Linnaeus), is a notorious pest of brassica crops worldwide and is resistant to all groups of insecticides. The insect system harbors diverse groups of microbiota, which in turn helps in enzymatic degradation of xenobiotic-like insecticides. The present study aimed to determine the diversity of gut microfl
Braz. J. Microbiol.. Publicado em: 2016-06
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2. Efeito da resistência de Spodoptera frugiperda (J.E.Smith, 1797) (Lepidoptera: Noctuidae) a lambda-cyhalothrin na interação com o milho geneticamente modificado (MON810) e na resposta imunológica ao parasitismo por Campoletis af / Effect of resistance of Spodoptera frugiperda (J.E. Smith, 1797) (Lepidoptera: Noctuidae) to lambda-cyhalothrin on the interaction with genetically modified maize (MON810) and the immune response to parasitization by Campoletis aff. flavicincta (Hymenoptera: Ichneumonidae)
Fitness costs of insect resistance to insecticides can be exploited by integrating other pest control strategies in Integrated Pest Management (IPM) programs. The objective of this research was to evaluate the existence of fitness costs associated with the resistance of Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae) to the pyrethroid insecticid
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/05/2012
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3. Avaliação de polimorfismos de genes metabolizadores de xenobióticos em pacientes com câncer de cabeça e pescoço.
Alguns indivíduos podem apresentar risco aumentado de desenvolver o câncer devido às diferenças no biometabolismo. Polimorfismos em genes metabolizadores de xenobióticos, tais como os membros da família do Cytocromo P450 (CYP), das Glutatião-S-Transferases (GSTs) e Epóxido Hidrolase Microssomal (mEH) mostram associação com a carcinogênese de cabe�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/05/2011
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4. Toxicidade aguda e respostas metabólicas e hematológicas do pacu (Piaractus mesopotamicus, Holmberg, 1887) exposto a concentração sub-letal de triclorfon e recuperação
Parasitosis in fishes is a relevant problem in aquaculture. Besides, the organophosphate trichlorfon (2,2,2-trichloro-1-hydroxyethyl phosphonate) is amongst the most used medicine in farming of fishes. Due to trichlorfon use in fish parasitosis control, including pacu (Piaractus mesopotamicus), in brazilian and worldwide aquaculture, it is necessary to study
Publicado em: 2010
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5. Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants
Individual variability in xenobiotic metabolism has been associated with susceptibility to developing complex diseases. Genes involved in xenobiotic metabolism have been evaluated in association studies; the difficulty of obtaining accurate gene frequencies in mixed populations makes interpretation of the results difficult. We sought to estimate population p
Genetics and Molecular Biology. Publicado em: 23/10/2009
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6. Sobre os efeitos quimiopreventivos e antitumorais do guaraná, Paullinia cupana Mart var. sorbilis, em modelos experimentais in vivo e in vitro / On the chemopreventive and antineoplastic effects of guarana, Paullinia cupana Mart var. sorbilis, in in vivo and in vitro experimental models
O câncer é a segunda maior causa de morte no Brasil, atrás apenas de doenças cardíacas. Por isto, é evidente que grandes recursos sejam direcionados para a pesquisa no descobrimento de novas opções com a finalidade de erradicar esta doença. Dentre estas opções, a quimioprevenção do câncer tem chamado a atenção já que, mesmo com os imensos av
Publicado em: 2008
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7. Oxidative stress: molecular perception and transduction of signals triggering antioxidant gene defenses
Molecular oxygen (O2) is the premier biological electron acceptor that serves vital roles in fundamental cellular functions. However, with the beneficial properties of O2 comes the inadvertent formation of reactive oxygen species (ROS) such as superoxide (O2·-), hydrogen peroxide, and hydroxyl radical (OH·)
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-07
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8. CARACTERIZAÇÃO GENOTÍPICA E ALÉLICA DO GLUTATIONA S-TRANSFERASE CLASSE , ENZIMA DO METABOLISMO DE XENOBIÓTICOS / Characterization Genotypic and Allelics of the Glutationa S-Transferase Class , Enzyme of the Metabolism of Xenobiotic
O gene de GSTM1, localizado no cromossomo 1p13.3, codifica enzimas citosólicas GST-mu. GSTs (EC 2.5.1.18) constituem uma família de enzimas multifuncionais, diméricas, envolvidas na fase 2 do metabolismo de drogas e carcenógenos, responsáveis pela biotransformação de xenobióticos e desintoxicação. A química fundamental catalisada pela GST envolve
Publicado em: 2005
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9. Implicações toxicologicas e bioquimicas de xenobioticos em Curimbata (Prochilodus scrofa, Steindachnner, 1881) um peixe tropical brasileiro
Cytochromes P450 constitute a superfamily of hemeproteins that play a vital role in the metabolism of a wide variety of compounds such as steroids, fatty acids, drugs and environmental pollutants. Xenobiotic metabolism and role of cytochrome P450 are important areas of molecular pharmacology and toxicology, and of great interest mainly in the studies on prev
Publicado em: 2002
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10. Glutathione S-transferase Mu (GSTM1) null genotype in relation to gender, age and smoking status in a healthy Brazilian population
The glutathione S-transferase mu (GSTM1) gene which acts during phase II of xenobiotic metabolism is polymorphic in the population, being absent in about 30-50% of individuals depending on the ethnic group from which they come. Epidemiological studies suggest that individuals who are homozygous null at the GSTM1 locus may have an increased risk of developing
Genetics and Molecular Biology. Publicado em: 2002
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11. A micromethod for quantitation of debrisoquine and 4-hydroxydebrisoquine in urine by liquid chromatography
We describe a new simple, selective and sensitive micromethod based on HPLC and fluorescence detection to measure debrisoquine (D) and 4-hydroxydebrisoquine (4-OHD) in urine for the investigation of xenobiotic metabolism by debrisoquine hydroxylase (CYP2D6). Four hundred µl of urine was required for the analysis of D and 4-OHD. Peaks were eluted at 8.3 min
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-05
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12. Effects of pregnancy and protein-energy malnutrition on monooxygenase O-dealkylation activity in rat liver microsomes
Xenobiotic metabolism is influenced by a variety of physiological and environmental factors including pregnancy and nutritional status of the individual. Pregnancy has generally been reported to cause a depression of hepatic monooxygenase activities. Low-protein diets and protein-energy malnutrition have also been associated with a reduced activity of monoox
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-01