Visual Deficient
Mostrando 13-24 de 37 artigos, teses e dissertações.
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13. Rdh12 Activity and Effects on Retinoid Processing in the Murine Retina*
RDH12 mutations are responsible for early-onset autosomal recessive retinal dystrophy, which results in profound retinal pathology and severe visual handicap in patients. To investigate the function of RDH12 within the network of retinoid dehydrogenases/reductases (RDHs) present in retina, we studied the retinal phenotype of Rdh12-deficient mice. In vivo rat
American Society for Biochemistry and Molecular Biology.
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14. Turnover of Phospholipids in Normal and Phosphorus-deficient Spirodela
When 32P1 was supplied as a 15-minute pulse to normal Spirodela oligorrhiza plants, the first phospholipid to become fully labeled was phosphatidic acid. Phosphatidyl glycerol reached maximum labeling before the other major phospholipids. In phosphorus-deficient plants, however, phosphatidyl glycerol became labeled much more slowly than either phosphatidyl c
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15. Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys.
Docosahexaenoic acid [22:6 omega 3; 22:6-(4,7,10,13,16,19)] is the major polyunsaturated fatty acid in the photoreceptor membranes of the retina and in cerebral gray matter. It must be obtained either from the diet or by synthesis from other omega 3 fatty acids, chiefly alpha-linolenic acid (18:3 omega 3). We tested the effect of dietary omega 3 fatty acid d
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16. Investigations on the Role of Boron in Plants III. Anatomical Observations 12
Electron microscopic examination of leaf mesophyll cells of boron-deficient sunflower plant reveals that chloroplasts degenerate and cell walls undergo profound structural changes before any visual deficiency symptoms become apparent. Mitochondria, which increase in number as deficiency develops, frequently show myeline figures, while nuclei may develop dens
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17. Memory Functioning in Developmental Dyslexia: An Analysis Using Two Clinical Memory Measures
The goals of this project were threefold: to determine the nature of the memory deficit in children/adolescents with dyslexia, to utilize clinical memory measures in this endeavor, and to determine the extent to which semantic short-term memory (STM) is related to basic reading performance. Two studies were conducted using different samples, one incorporatin
Oxford University Press.
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18. Reading type for children.
Young children experience difficulty with the present reading charts, and it may not be easy to decide whether this is due to visual problems or is associated with a deficient reading ability of the material presented to them. A reading chart has therefore been designed containing material graded according to the expected average ability for different age gr
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19. A mouse model of gyrate atrophy of the choroid and retina. Early retinal pigment epithelium damage and progressive retinal degeneration.
Gyrate atrophy (GA) of the choroid and retina is a blinding chorioretinal degeneration caused by deficiency of ornithine delta-aminotransferase (OAT). The phenotype of GA is characterized by progressive concentric reduction of the visual fields and ornithine accumulation. To understand better the pathogenesis of GA and to develop a model to test therapeutic
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20. Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle
RPE65 is essential for isomerization of vitamin A to the visual chromophore. Mutations in RPE65 cause early-onset blindness, and Rpe65-deficient mice lack 11-cis-retinal but overaccumulate alltrans-retinyl esters in the retinal pigment epithelium (RPE). RPE65 is proposed to be a substrate chaperone but may have an enzymatic role because it is closely related
National Academy of Sciences.
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21. Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys.
Linolenic acid (18:3 omega 3) is a dietary precursor of docosahexaenoic acid (22:6 omega 3), the major fatty acid in the photoreceptor membranes of the retina. We hypothesized that rhesus monkeys deprived of dietary omega-3 fatty acids during prenatal and postnatal development would show plasma depletion of these fatty acids and visual impairment. Semipurifi
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22. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness
Mutations in the retinal pigment epithelium gene encoding RPE65 are a cause of the incurable early-onset recessive human retinal degenerations known as Leber congenital amaurosis. Rpe65-deficient mice, a model of Leber congenital amaurosis, have no rod photopigment and severely impaired rod physiology. We analyzed retinoid flow in this model and then interve
The National Academy of Sciences.
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23. Hemispheric lateralization of singing after intracarotid sodium amylobarbitone1
Hemispheric lateralization of singing was investigated in patients who had transient hemiplegia after intracarotid injection of sodium amylobarbitone. It was found that after right carotid injection singing was markedly deficient, whereas speech remained relatively intact. Songs were sung in a monotone, devoid of correct pitch rendering; rhythm was much less
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24. Mechanisms of nonopsonic phagocytosis of Pseudomonas aeruginosa.
The interaction of the macrophage cell line P388D1 with Pseudomonas aeruginosa in the absence of stimulators or opsonins led to substantial association of bacteria, as judged by visual counting and FACScan assays. This association was observable within 5 min of addition of bacteria, could not be disturbed by exhaustive washing, and occurred with pilus- or fl