Venoms
Mostrando 13-24 de 272 artigos, teses e dissertações.
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13. Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
Abstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-depe
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 15/04/2019
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14. Functional and biological insights of rCollinein-1, a recombinant serine protease from Crotalus durissus collilineatus
ABSTRACT Background: The prevalent class of snake venom serine proteases (SVSP) in Viperidae venoms is the thrombin-like enzymes, which, similarly to human thrombin, convert fibrinogen into insoluble fibrin monomers. However, thrombin-like serine proteases differ from thrombin by being unable to activate factor XIII, thus leading to the formation of loose c
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 08/04/2019
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15. BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells
Abstract Background: The use of animal venoms and their toxins as material sources for biotechnological applications has received much attention from the pharmaceutical industry. L-amino acid oxidases from snake venoms (SV-LAAOs) have demonstrated innumerous biological effects and pharmacological potential against different cancer types. Hepatocellular carc
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/03/2019
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16. Kinetic investigations and stability studies of two Bothrops L-amino acid oxidases
Abstract Background: L-amino acid oxidases isolated from snake venoms (SV-LAAOs) are enzymes that have great therapeutic potential and are currently being investigated as tools for developing new strategies to treat various diseases, including cancer and bacterial infections. The main objective of this study was to make a brief evaluation of the enzymatic s
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/01/2019
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17. Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties
Abstract For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus. However, in the past decades, progressive studies have led researchers to shift their focus on Crotoxin, op
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/01/2019
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18. Antivenomic approach of different Crotalus durissus collilineatus venoms
Abstract Background: Our group has previously performed a proteomic study verifying that individual variations can occur among Crotalus durissus collilineatus venoms. These variations may lead to differences in venom toxicity and may result in lack of neutralization of some components by antivenom. In this way, this study aimed to evaluate the Brazilian ant
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 17/12/2018
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19. Deep sequencing analysis of toad Rhinella schneideri skin glands and partial biochemical characterization of its cutaneous secretion
Abstract Background: Animal poisons and venoms are sources of biomolecules naturally selected. Rhinella schneideri toads are widespread in the whole Brazilian territory and they have poison glands and mucous gland. Recently, protein from toads’ secretion has gaining attention. Frog skin is widely known to present great number of host defense peptides and
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 17/12/2018
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20. Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorioallantoic membrane model
Abstract Background: The great diversity of molecules found in spider venoms include amino acids, polyamines, proteins and peptides, among others. Some of these compounds can interact with different neuronal receptors and ion channels including those present in the ocular system. To study potential toxicity and safety of intravitreal injection in rabbits of
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 17/12/2018
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21. Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom
Abstract Background: In recent decades, snake venom disintegrins have received special attention due to their potential use in anticancer therapy. Disintegrins are small and cysteine-rich proteins present in snake venoms and can interact with specific integrins to inhibit their activities in cell-cell and cell-ECM interactions. These molecules, known to inh
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/11/2018
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22. Pharmacological characterization of cnidarian extracts from the Caribbean Sea: evaluation of anti-snake venom and antitumor properties
Abstract Background: Cnidarians produce toxins, which are composed of different polypeptides that induce pharmacological effects of biotechnological interest, such as antitumor, antiophidic and anti-clotting activities. This study aimed to evaluate toxicological activities and potential as antitumor and antiophidic agents contained in total extracts from fi
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 21/09/2018
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23. Hemolytic, anticancer and antigiardial activity of Palythoa caribaeorum venom
Abstract Background Cnidarian venoms and extracts have shown a broad variety of biological activities including cytotoxic, antibacterial and antitumoral effects. Most of these studied extracts were obtained from sea anemones or jellyfish. The present study aimed to determine the toxic activity and assess the antitumor and antiparasitic potential of Palythoa
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/05/2018
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24. Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand
Abstract Background: Envenoming by kraits (genus Bungarus) is a medically significant issue in South Asia and Southeast Asia. Malayan krait (Bungarus candidus) venom is known to contain highly potent neurotoxins. In recent years, there have been reports on the non-neurotoxic activities of krait venom that include myotoxicity and nephrotoxicity. However, res
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 07/05/2018