Ursodeoxycholic Acid
Mostrando 1-12 de 34 artigos, teses e dissertações.
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1. N-ACETYLCYSTEINE AND/OR URSODEOXYCHOLIC ACID ASSOCIATED WITH METFORMIN IN NON-ALCOHOLIC STEATOHEPATITIS: AN OPEN-LABEL MULTICENTER RANDOMIZED CONTROLLED TRIAL
RESUMO CONTEXTO: Atualmente, o tratamento farmacológico da doença hepática gordurosa não alcoólica (DHGNA) ainda é limitado e baseia-se no tratamento de condições associadas às comorbidades. O estresse oxidativo e a resistência à insulina são os mecanismos que parecem estar mais envolvidos em sua patogênese. OBJETIVO: Avaliar a eficácia da
Arq. Gastroenterol.. Publicado em: 26/08/2019
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2. Protective effect of Echinochrome against intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats
Resumo O presente estudo destinou-se a avaliar os efeitos protetores do Ech na colestase intra-hepática em ratos induzidos por uma única injeção (i.p.) de alfa-naftilisotiocianato (ANIT) (75 mg / kg de peso corporal). Os ratos foram pré-tratados oralmente durante 48 horas (uma dose / 24 horas) com cada (1, 5 e 10 mg / kg de peso corporal) e ácido urso
Braz. J. Biol.. Publicado em: 18/04/2019
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3. Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
Abstract Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of
Acta Cir. Bras.. Publicado em: 14/02/2019
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4. Use of Ursodeoxycholic Acid on Post-menopausal Obesity, Hepatic steatosis and Plasma Profile as an Alternative Treatment for Hormone Replacement Therapy
ABSTRACT The aim of this study was to evaluate the efficacy of the ursodeoxycholic acid (UDCA) as an alternative treatment for menopause pathologies. For this, female Swiss-CD-1 mice were ovariectomized (OVX); SHAM operated mice served as controls. Ten weeks after operation, each group of mice was treated during four weeks with either UDCA, or 17(-estradiol+
Braz. arch. biol. technol.. Publicado em: 2015-12
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5. Efeito do ácido ursodesoxicólico e o papel da mucosa no desenvolvimento de dismotilidade esofagiana: estudo experimental com cobaias / Effects of ursodeoxycholic acid and the role of mucosa in esophageal dysmotility. An experimental study
Background and Aims: Esophageal motor abnormalities are frequently found in patients with gastroesophageal reflux disease. The role of bile in reflux-induced dysmotility is still elusive. Furthermore, it is questionable weather mucosal or muscular stimulation leads to motor modification. The aims of this study were: (a) analyze the effect of bile infusion in
Publicado em: 2010
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6. Desenvolvimento de mÃtodos analÃticos rÃpidos e de baixo custo utilizando ciclodextrinas para o controle de qualidade de fÃrmacos
O Ãcido desoxicÃlico (DCA) e o Ãcido ursodesoxicÃlico (UDCA) sÃo Ãcidos biliares com inÃmeras aplicaÃÃes farmacÃuticas, no entanto, as metodologias empregadas para determinaÃÃo de suas concentraÃÃes sÃo demoradas e onerosas. Neste trabalho foram usadas as ciclodextrinas, oligossacarÃdeos cÃclicos, que tÃm a capacidade de formar complexos de
Publicado em: 2009
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7. 20 anos de hepatite auto-imune no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo / 20-Year follow up of autoimmune hepatitis in Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Autoimmune hepatitis (AIH) is a chronic liver disease in which there is a progressive destruction of the hepatic parenchyma, leading to cirrhosis without treatment. Previous publications reported some regional and racial differences in clinical, laboratorial, histologic features and treatment response of this disease, probably related to genetic backgrounds
Publicado em: 2008
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8. A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid
In order to determine the effect of ursodeoxycholic acid on nonalcoholic fatty liver disease, 30 patients with body mass indices higher than 25, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) or gamma-glutamyltransferase (gamma-GT) at least more than 1.5 times the upper limit of normality, and hepatic steatosis demonstrated
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-06
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9. Increased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid.
The formation of ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, was investigated in three subjects with cerebrotendinous xanthomatosis and in four subjects with gallstones. Total biliary bile acid composition was analyzed by gas-liquid chromatography before and after 4 months of treatment with 0.75 g/day of chenodeoxycholic acid. I
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10. Adsorption of Lithocholic Acid to Fusarium equiseti M41 as an Essential Process in Its Conversion to Ursodeoxycholic Acid
Fusarium equiseti M41 converts lithocholic acid to ursodeoxycholic acid. Adsorption of lithocholic acid particles to mycelia of F. equiseti M41 is essential in the conversion of lithocholic acid to ursodeoxycholic acid. Production of ursodeoxycholic acid was negligible when particles of lithocholic acid were absent. As the concentration of lithocholic acid p
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11. Microbial Production of Ursodeoxycholic Acid from Lithocholic Acid by Fusarium equiseti M41
A fungus identified as Fusarium equiseti was isolated from soil and found to carry out 7β-hydroxylation of lithocholic acid to ursodeoxycholic acid (35% yield; 350 mg/liter) in 112 h.
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12. Optimum conditions for ursodeoxycholic acid production from lithocholic acid by Fusarium equiseti M41.
Ursodeoxycholic acid dissolves cholesterol gallstones in humans. In the present study optimum conditions for ursodeoxycholic acid production by Fusarium equiseti M41 were studied. Resting mycelia of F. equiseti M41 showed maximum conversion at 28 degrees C, pH 8.0, and dissolved oxygen tension of higher than 60% saturation. Monovalent cations, such as Na+, K