Urinary Porphyrins
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Porfiria cutânea tardia com mutações do gene da hemocromatose C282Y e H63D e análise retrospectiva do perfil de ferro em relação ao tratamento: estudo de 60 casos / Porphyria cutanea tarda with hemochromatosis gene mutations C282Y and H63D and retrospective analysis of the iron profile in relation to treatment: study of 60 cases
Background: Porphyria cutanea tarda (PCT) is the most common form of porphyria and is characterized by the decreased activity of the uroporphyrinogen decarboxylase enzyme. Several reports associated HFE gene mutations of hereditary hemochromatosis with PCT worldwide, although up to date only one study has been conducted in Brazil. Objective: Study the associ
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/10/2012
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2. Spot urine porphyrins/creatinine ratio profile of healthy Brazilian individuals adjusted for personal habits
Changes in urinary porphyrin excretion may be the result of hereditary causes and/or from environmental or occupational exposure. The objective of this study was to measure the amount of some porphyrins in spot urine samples obtained from volunteers randomly selected from a healthy adult population of São Paulo with a sensitive HPLC method and to estimate n
Brazilian Journal of Medical and Biological Research. Publicado em: 15/05/2009
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3. Urinary porphyrins reference ranges by HPLC in a population not exposed to porphyrinogenic agents / Valores de referência de porfirinas urinárias por CLAE numa população não-exposta a agentes químicos porfirinogênicos
Porphyrins which are formed as intermediates in heme biosynthesis, vary from eight to four carboxyl groups: uro, hepta, hexa, penta and coproporphyrins. Alterations in the urinary porphyrin excretion profile may be caused by a hereditary disease or by environmental/occupational exposure. The purpose of this study was to establish a sensitive and accurate hig
Publicado em: 2005
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4. The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage
We evaluated the porphyrinogenic ability of ethanol (20% in drinking water) per se, its effect on the development of sporadic porphyria cutanea tarda induced by hexachlorobenzene in female Wistar rats (170-190 g, N = 8/group), and the relationship with hepatic damage. Twenty-five percent of the animals receiving ethanol increased up to 14-, 25-, and 4.5-fold
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-11
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5. Acute intermittent porphyria: clinical study of 37 cases. / Porfiria aguda intermitente: estudo clínico de 37 casos.
Acute intermittent porphyria is an autosomal dominant disease, caused by a disturbance in the heme biosynthetic pathway, secondary to the reduction on the levels of uroporphyrinogen-I-synthetase enzyme. Clinical manifestations involve central and peripheral nervous system. The diagnosis is based on the elevated urinary excretion of porphyrins precursors d-am
Publicado em: 2001
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6. Paper Electrophoresis of Urinary Porphyrins
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7. A simplified method for rapid determination of porphyrins by thin-layer chromatography.
Free porphyrins, especially copro-, uro-, and protoporphyrin, were successfully separated by talc thin-layer chromatography (TLC), and were determined from the relationship of the weight and the area of porphyrins in the spot on the thin-layer plate. The results obtained from both the solvent extraction and the simple, rapid TLC method reported in this paper
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8. CONCERNING THE NATURALLY OCCURRING PORPHYRINS. IV. THE URINARY PORPHYRIN IN LEAD POISONING AS CONTRASTED WITH THAT EXCRETED NORMALLY AND IN OTHER DISEASES 1
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9. Plasma Porphyrins in Lead Workers
Plasma porphyrin levels were determined in a group of 50 workers exposed to lead. The mean value obtained (0·7 μg./100 ml.) was found to be higher than that obtained from a control group (0·2 μg./100 ml.). Although urinary porphyrin levels in the lead workers were also higher than in the control group, no correlation was found between plasma porphyrin le
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10. A simple method for the separation and quantification of urinary porphyrins.
A simple routine method for the separation and quantification of urinary coproporphyrin and uroporphyrin using anion-exchange resin columns is described. The coproporphyrin is first removed from the urine by ether extraction. The anion exchange resin column is then used to isolate the uroporphyrin from the aqueous residue. The proposed method is compared wit
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11. A mouse model of familial porphyria cutanea tarda
Approximately one-third of patients with porphyria cutanea tarda (PCT), the most common porphyria in humans, inherit a single mutant allele of the uroporphyrinogen decarboxylase (URO-D) gene. PCT associated with URO-D mutations is designated familial PCT. The phenotype is characterized by a photosensitive dermatosis with hepatic accumulation and urinary
The National Academy of Sciences.
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12. Lead poisoning in a group of demolition workers.
The incidence of lead poisoning in industry has fallen dramatically since the beginning of the twentieth century. This reduction has been partly attributable to increased awareness, improved ventilation and hygiene facilities, and technical changes which have allowed other substances to replace lead, but improved medical surveillance of workers exposed to le