Trypsin Inhibitors
Mostrando 13-24 de 255 artigos, teses e dissertações.
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13. HydroPaCe: uma metodologia para análise de inibição cruzada em serino proteases através de centroides de regiões hidrofóbicas
Interfaces of protein-protein interactions contain important information about molecular recognition. This work aims at the discovery of conserved patterns in this region. We believe it is essential to understand how substrates and inhibitors are bound and for predicting molecular binding. When an inhibitor binds to enzymes with different structures, sequenc
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/11/2011
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14. Efeito dos processos de irradiação e germinação nos aspectos nutricionais, sensoriais e microbiológicos em grãos de soja (Glycine m ax Merril) cultivar BRS216 / Effect of irradiation and germination processes in the nutritional, sensory and microbiological in soybeans (Glycine max Merrill) cultivra BRS216
Soybean (Gycine max (L.) Merrill) is an important legume for human diets due its potential health benefits. Because of the increasing stimulus to soybean consumption, mainly due to its several bioactive compounds, some processing methods have been studied as a way to know changes that occur in these compounds during the processes. Thus, this study aimed to a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/10/2011
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15. CORRELAÇÃO DA ATIVIDADE DO PROTEASSOMA, EXPRESSÃO DE CD44 E ENZIMAS PROTEOLÍTICAS EM EXTRATOS INTESTINAIS DE CAMUNDONGOS TRATADOS COM 1,2 DIMETILHIDRAZINA E INIBIDORES BOWMAN-BIRK
The Bowman-Birk inhibitors (BBI) are protein molecules containing two distinct inhibitory domains for trypsin and chymotrypsin-like enzymes. The interest for this class of inhibitors is based on studies which demonstrated a protective effect promoted by BBI, particularly for chemically-induced cancers. In the present work, we evaluated the effects of BBI iso
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/06/2011
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16. Inhibition of pancreatic lipase by extracts of Baccharis trimera (Less.) DC., Asteraceae: evaluation of antinutrients and effect on glycosidases
In order to confirm the traditional use of Baccharis trimera (Less.) DC., Asteraceae, for the reduction of weight, plant extracts were evaluated on the activity of pancreatic lipase (PL), an enzyme responsible for hydrolysis of triacylglycerols in the diet for its subsequent absorption. The aqueous and infused extracts did not show inhibitory activity on the
Revista Brasileira de Farmacognosia. Publicado em: 01/04/2011
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17. Analysis of binding properties and specificity through identification of the interface forming residues (IFR) for serine proteases in silico docked to different inhibitors.
Background: Enzymes belonging to the same super family of proteins in general operate on variety of substrates and are inhibited by wide selection of inhibitors. In this work our main objective was to expand the scope of studies that consider only the catalytic and binding pocket amino acids while analyzing enzyme specificity and instead, include a wider cat
BMC Structural Biology. Publicado em: 2011
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18. CaracterizaÃÃo BioquÃmica Parcial do LÃtex de Cryptostegia grandiflora R. Br. e AÃÃo Contra o Vetor da Dengue. / Biochemical characterization of latex of Cryptostegia grandiflora and larvicidal activity against Aedes aegypti
Cryptostegia grandiflora R. Br. is a shurb belonging to Apocynaceae family popularly known as âunha de bruxaâ. There are few studies available about the latex from this species and preliminary assays had shown its action against Dengue vector. Thus, this study aimed to characterize the biochemical properties of Cr. grandiflora latex and to evaluate the act
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/02/2010
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19. Clonagem, expressão e caracterização de um inibidor de tripsina presente no mosquito Aedes aegypti / Cloning, expression and characterization of a trypsin inhibitor from Aedes aegypti mosquito.
The Aedes aegypti mosquito is the classic vector of yellow fever and dengue fever. In haematophagous insects, blood digestion is carried out by proteolitic enzymes, which can also be envolved in parasite-vector relationship. Blood feeding requires that haematophagous insects are able to inhibit host hemostatic defenses, containing inhibitors of coagulation c
Publicado em: 2010
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20. Purification and structural stability of a trypsin inhibitor from Amazon Inga cylindrica [Vell.] Mart. seeds
Inga cylindrica Trypsin Inhibitor (ICTI) was purified as a single polypeptide chain by one step anion-exchange chromatography from a crude extract of Inga cylindrica (Vell.) Mart. seeds. ICTI is a 19.5 kDa protein presenting a remarkable inhibitory activity against bovine trypsin (EC 3.4.21.4) (Ki = 4.3 nM). Circular dichroism analysis revealed that this inh
Brazilian Journal of Plant Physiology. Publicado em: 2010
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21. Novas propriedades do SKTI (Inibidor de tripsina de soja): inibição para elastase neutrofílica humana e efeitos no processo de injúria pulmonar aguda
Seeds from legumes including the Glycine max are known to be a rich source of protease inhibitors. The soybean Kunitz trypsin inhibitor (SKTI) has been well characterised and has been found to exhibit many biological activities. However its effects on inflammatory diseases have not been studied to date. In this study, SKTI was purified from a commercial soy
Publicado em: 2010
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22. Efeito do inibidor de tripsina de sementes de Adrenanthera pavonina sobre os lepidopteros Anticarsia gemmatalis e Anagasta kuehniella / The effects of the trypsin inhibitor from Adrenanthera pavonina seeds on the lepidopteros Anticarsia gemmatalis and Anagasta kuehniella
As sementes são ricas fontes de inibidores de proteinases, que prejudicam sua qualidade nutricional, reduzindo a digestibilidade das proteínas e sua absorção. Neste estudo, um inibidor de tripsina (ApTI) foi purificado a partir de sementes de Adenanthera pavonina e testado seu efeito no crescimento e desenvolvimento de dois lepidópteros. Larvas de Anaga
Publicado em: 2010
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23. Planejamento por modelagem molecular e síntese de inibidores potenciais de serino proteases
Serine proteases are a class of enzymes of great therapeutic importance. Their role in critical biological processes like digestion, blood coagulation, fibrinolysis and immune response make them promising targets for the development of new drugs. Aiming at the synthesis of potential serine protease inhibitors a set of ten molecules was subjected to a molecul
Publicado em: 2009
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24. Identificação e mapeamento de genes para uso na seleção assistida de genótipos de soja com ausência do inibidor de tripsina Kunitz e lipoxigennases
Soybean (Glycine max (L.) Merrill) is a food with high levels of proteins, minerals and fibres, and a reduced amount of saturated fat bringing benefits to humans health. However, the use of the product for human and animal feeding is limited to the presence of some antinutritional factors, as trypsin inhibitors and lipoxygenases enzymes. The development of
Publicado em: 2009