Transdermal Drug Delivery
Mostrando 1-12 de 35 artigos, teses e dissertações.
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1. Therapeutic response and safety of the topical, sequential use of antiseptic, keratolytic, and pentamidine creams (3-PACK) on Leishmania (Viannia) braziliensis-infected mice
BACKGROUND Topical treatment of New World cutaneous leishmaniasis can be affected by bacterial coinfection, hyperkeratosis, and transdermal drug delivery. OBJECTIVE The aim of this work was to evaluate the therapeutic response and safety of the topical, sequential use of antiseptic, keratolytic, and pentamidine isethionate (PMD) creams (3-PACK kit) on CL
Mem. Inst. Oswaldo Cruz. Publicado em: 13/05/2019
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2. Influence of different formulation variables on the performance of transdermal drug delivery system containing tizanidine hydrochloride: in vitro and ex vivo evaluations
The present study was aimed at preparation of transdermal patches of tizanidine HCl, evaluation of the effect of polymers on in vitro release pattern of the drug, and the effect of permeation enhancers on the penetration of the drug through the rabbit skin. Various proportions of hydrophilic (HPMC) and hydrophobic (Eudragit L-100) polymers were used with PEG
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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3. Physical methods for topical skin drug delivery: concepts and applications
Topical drug delivery is an interesting approach to treat skin diseases and to avoid pain and low patient compliance in cases where a systemic delivery is required. However, the stratum corneum, which is the outermost skin layer, strongly protects the body from the entrance of substances, especially those hydrophilic. In this context, different physical meth
Braz. J. Pharm. Sci.. Publicado em: 08/11/2018
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4. Evaluation of skin absorption of drugs from topical and transdermal formulations
ABSTRACT The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal f
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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5. Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate
O objetivo do presente estudo foi desenvolver um sistema de liberação transdérmico do tipo reservatório para o dinitrato de isossorbida (ISDN, abrevitura em Inglês). A formulação transdérmica desenvolvida constou de cinco camadas de baixo para cima, ou seja, um revestimento temporário, uma camada adesiva, uma membrana controladora da taxa de libe
Braz. J. Pharm. Sci.. Publicado em: 2015-06
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6. Transdermal formulations containing human sexual steroids: development and validation of methods and in vitro drug release
In vitro release of bioidentical hormones in four different liposomal transdermal emulsions (containing testosterone, progesterone, estradiol, or estradiol and estriol) was assessed. For this purpose, novel high-performance liquid chromatography methods were developed and validated in an eco-friendly manner and used to determine the in vitro release of such
Quím. Nova. Publicado em: 2014
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7. Princípios básicos e aplicação da iontoforese na penetração cutânea de fármacos
Physicochemical constraints severely limit the number of molecules that can be considered as candidates for transdermal delivery. Iontophoresis is a non-invasive technique in which a weak electric current is used to enhance the penetration of molecules into or through the skin. In this review the underlying mechanisms that drive iontophoresis and the impact
Química Nova. Publicado em: 2008
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8. Transdermal drug delivery treatment for overactive bladder
Overactive bladder is commonly treated with oral anticholinergic drugs such as oxybutynin chloride. Although oral anticholinergic agents have been effective in controlling urinary urgency and incontinence, adverse events, particularly dry mouth, often cause patients to discontinue oral therapy and to endure incontinence. Oxybutynin can be delivered transcuta
International braz j urol. Publicado em: 2006-10
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9. Estudo da fonoforese de ciclofenaco dietilamonio em voluntarios sadios / Study of diclofenac diethylammonium phonophoresis in healthy human volunteers
Transdermal drug delivery with therapeutic ultrasound, method called phonophoresis, offers many advantages when compared to other drug delivery methods. The aim of this study was to verify the influence of ultrasound on the transdermal delivery of diclofenac diethylammonium (Cataflam Emulgel®, Novartis) post phonophoresis in healthy volunteers. Twelve healt
Publicado em: 2006
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10. Ruthenium complexes with nitrosil group as donnors agents of nitric oxide. Chemical and Physical aspects of its applications as therapeutical agents" / Complexos de rutênio com nitrosil como agentes doadores de óxido nítrico. Aspectos químicos e físico-químicos de suas aplicações como agentes terapêuticos"
Nitric oxide activity in chemistry and biology is not yet fully discovered. There are more than 5,000 papers alone on this subject each year. A lot more work needs to be done in this area. For people in biology who want to study how nitric oxide works in different systems, they need some kind of model compound to release nitric oxide to help them do their ph
Publicado em: 2004
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11. ObtenÃÃo, caracterizaÃÃo e avaliaÃÃo microbiolÃgica de uma nova forma farmacÃutica contendo hidroquinona
Hydroquinone (HQ) is a drug reported to possess manifold biological activities, such as depigmenting, antimicrobial and antitumour properties. The PluronicLecithin Organogel (PLOme) is a phospholipidic microemulsion particularly implied when a high cutaneous permeability and systemic absorption of a drug is suitable. Once that HQ is highly unstable i
Publicado em: 2003
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12. Comparative study of the efficacy of phonophoresis, therapeutic ultrasound and topic hydrocortisone application in the treatment of rat tendon in tissue repair process / Estudo comparativo da eficácia da fonoforese, do ultra-som terapêutico e da aplicação tópica de hidrocortisona no tratamento do tendão de rato em processo de reparo tecidual
A proposta deste estudo foi comparar a eficácia de tratamento da aplicação tópica de hidrocortisona, do ultra-som terapêutico e da fonoforese no processo de reparo do tendão de Aquiles (tendo calcaneus) de ratos, após tenotomia. O grupo controle foi definido como tenotomizados com simulação da aplicação sônica e tendões não tenotomizados. Os do
Publicado em: 2003