Princípios básicos e aplicação da iontoforese na penetração cutânea de fármacos
AUTOR(ES)
Gratieri, Taís, Gelfuso, Guilherme Martins, Lopez, Renata Fonseca Vianna
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2008
RESUMO
Physicochemical constraints severely limit the number of molecules that can be considered as candidates for transdermal delivery. Iontophoresis is a non-invasive technique in which a weak electric current is used to enhance the penetration of molecules into or through the skin. In this review the underlying mechanisms that drive iontophoresis and the impact of key experimental parameters - namely, formulation, drug concentration and pH - on iontophoretic delivery efficiency are discussed. In the final section some devices that are currently commercialized are also described.
