Transcription Factors Physiology
Mostrando 1-12 de 36 artigos, teses e dissertações.
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1. O diabetes altera a expressão do RNAm do GLUT2 em fígado e rim: participação dos fatores transcricionais Hepatic Nuclear Factor - (HNF-) 1a, 3b e 4a. / The diabetes alters the mRNA expression of GLUT2 in liver and kidney: involvement of transcription factors Hepatic Nuclear Factor-(HNF)-1a, 3b, and 4a.
A homeostasia glicêmica requer uma estreita regulação quantitativa e temporal do fluxo de glicose em diferentes órgãos. O fluxo de glicose no fígado e no rim depende de um transportador específico, o GLUT2. Neste estudo demonstramos que em rim, o GLUT2 está aumentado no diabetes e que os fatores transcricionais HNF-1a, HNF-3
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/07/2011
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2. The effects of liposuction and exercise training on metabolic profile and body composition in adult normal weight healthy women / Efeitos da lipoaspiração acompanhada de treinamento físico no perfil metabólico e na composição corporal de mulheres adultas eutróficas e saudáveis
Liposuction is the most communly cosmetic surgery performed worlwide. Because adipose tissue is metabolicaly active, researchers have suggested that the surgical removal of fat through liposuction could benefically affect the metabolic profile. In addition, in many species, when body fat is removed, it is recovered rapidly due to compensatory fat growth at i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/05/2011
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3. Estudos dos genes Tbx19 e Crhr1 em cães da raça poodle com hipercortisolismo ACTH-dependente / Study of Tbx19 and Crhr1 genes in Poodle dogs with ACTH-dependent hypercortisolism
The ACTH-dependent hypercortisolism (ADH), also called Cushings disease, is one of the most commonly diagnosed endocrine diseases in dogs. The symptoms occur due to glucocorticoids excess leading to gluconeogenic, catabolic, anti-inflammatory and immunosuppressive effects in multiple organs and systems. There is a high incidence of Cushings disease in Poodle
Publicado em: 2010
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4. Papel da via lkaros-FGFR4 na evolução pós-cirúrgica dos pacientes com doença de Cushing / Ikaros-FGFR4 pathway: role in the postoperative outcome of Cushings disease
Introduction: The mechanisms involved in the molecular pathogenesis of corticotroph pituitary tumors are complex, heterogeneous and in most cases remain unknown. Changes in the expression of components of Ikaros (Ik) pathway, such as receptor 4 of fibroblast growth factor (FGFR4), have been detected in pituitary tumors including corticotropinomas. Imbalance
Publicado em: 2010
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5. Study of the Na+/H+ (NHE3) exchanger gene promoter region. / Estudo da região promotora do gene do permutador Na+/H+ (NHE3).
In view of the importance of the exchanger Na+/H+ (isoform 3), in reabsoption of NaCl and NaHCO3 in proximal tubules and consequently the acid-base balance, and cell volume, came the interest in identifying the region promoter essential for transcription of the NHE3 gene and the elements of the binding of transcription factors present in the same, in cells r
Publicado em: 2009
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6. Identification of photoperception and light signal transduction pathways in citrus
Studies employing model species have elucidated several aspects of photoperception and light signal transduction that control plant development. However, the information available for economically important crops is scarce. Citrus genome databases of expressed sequence tags (EST) were investigated in order to identify genes coding for functionally characteri
Genetics and Molecular Biology. Publicado em: 2007
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7. Analise funcional do regulador de transcrição do tipo bZIP AtbZIP9 de Arabidopsis thaliana atraves da superexpressão de seus genes alvos / Fucntional characterization of the Arabidopsis thaliana bZIP transcription factor AtbZIP9 by overexpression of its target genes
Transcriptional regulatory factors (TFs) play an important role in controlling growth and development of ali organisms. bZIPs TFs have been described in ali eukaryotes and are characterized by a basic aminoacid rich DNA binding domain and a leucine zipper, responsible for dimerization. bZIPs have been reported to act in several different plantspecific proces
Publicado em: 2007
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8. Free fatty acids increase insulin secretion and modulates expression of genes involved in insulin biosynthesis in islets from malnourished rats / Acido graxo aumenta a secreção de insulina e modula a expressão de genes envolvidos na biossintese de insulina em ilhotas de ratos submetidos a desnutrição proteica
A severe reduction in insulin release in response to glucose is consistently noticed in protein-deprived rats and is attributed partly to the chronic exposure to elevated levels of free fatty acids. Since the pancreatic and duodenal transcription factor homeobox 1 (PDX-1) is important for the maintenance of B-cell physiology, and since PDX-1 expression is al
Publicado em: 2006
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9. Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix
The extracellular matrix is a three-dimensional network of proteins, glycosaminoglycans and other macromolecules. It has a structural support function as well as a role in cell adhesion, migration, proliferation, differentiation, and survival. The extracellular matrix conveys signals through membrane receptors called integrins and plays an important role in
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-10
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10. NFAT transcription factors: from cell cycle to tumor development
The nuclear factor of activated T cells (NFAT) family of transcription factors has been primarily identified in immune cells; however, these proteins have been recently found to be functionally active in several other non-immune cell types. NFAT proteins are activated upon different stimuli that lead to increased intracellular calcium levels. Regardless of t
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-03
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11. Constitutive expression of zif268 in neocortex is regulated by synaptic activity.
Transcription factors are rapidly and transiently induced in brain by excitatory stimuli and may be important in coordinating changes in gene expression underlying neuronal plasticity. In contrast to their transient induction after stimulation, certain transcription factors display stable, relatively high basal levels of expression in brain. Here we demonstr
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12. Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for hypoxia-inducible factor-1α
A progressive rise of oxidative stress due to altered reduction–oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in physiology and pathophysiology. Reactive oxygen species and reactive nitrogen species serve as signaling messengers for the evolution and perpetuation of the inflammatory proce
BioMed Central.