Tp53
Mostrando 13-24 de 208 artigos, teses e dissertações.
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13. Comparison of multiple genotyping methods for the identification of the cancer predisposing founder mutation p.R337H in TP53
Abstract Germline mutations in the TP53 gene are associated with Li-Fraumeni and Li-Fraumeni-Like Syndromes, characterized by increased predisposition to early-onset cancers. In Brazil, the prevalence of the TP53-p.R337H germline mutation is exceedingly high in the general population and in cancer-affected patients, probably as result of a founder effect. Se
Genet. Mol. Biol.. Publicado em: 03/06/2016
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14. Early-onset breast cancer patients in the South and Southeast of Brazil should be tested for the TP53 p.R337H mutation
Abstract Germline TP53 mutations are associated with Li-Fraumeni syndrome (LFS), a disease that predisposes carriers to a wide variety of early onset tumors. In southern and southeastern Brazil, a high frequency of a germline TP53 mutation, p.R337H, was diagnosed in 0,3% of the population due to a founder effect. Carriers are at risk for developing cancer bu
Genet. Mol. Biol.. Publicado em: 24/05/2016
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15. Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil
Abstract In Brazil, breast cancer is a public health care problem due to its high incidence and mortality rates. In this study, we investigated the prevalence of hereditary breast cancer syndromes (HBCS) in a population-based cohort in Brazils southernmost capital, Porto Alegre. All participants answered a questionnaire about family history (FH) of breast, o
Genet. Mol. Biol.. Publicado em: 24/05/2016
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16. SÍNDROME DE BURNOUT EM ATLETAS INFANTO-JUVENÍS E JUVENÍS DE VOLEIBOL FEMININO PARTICIPANTES DO CAMPEONATO BRASILEIRO DE SELEÇÕES
RESUMO O Voleibol é um dos principais esportes do Brasil e para atingir bons níveis competitivos são necessários treinamentos com altos volume e intensidade, que consequentemente geram desgastes físicos e psicológicos. O resultado deste processo pode ocasionar um estresse crônico nos praticantes, conhecido como Síndrome de Burnout. O presente estudo
J. Phys. Educ.. Publicado em: 2016
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17. Association of XRCC1 Arg399GIn and Tp53 Arg72Pro polymorphisms and increased risk of uterine leiomyoma - A case-control study
Abstract The aim of present study was to investigate the role of the X-ray repair cross-complementing protein1 (XRCC1) and Tumor protein p53 (Tp53) polymorphisms in Uterine Leiomyoma (UL) susceptibility in southeastern Iran. This case control study was performed on 139 women with UL and 149 age, BMI and ethnicity matched healthy women. All women were genotyp
Genet. Mol. Biol.. Publicado em: 24/11/2015
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18. Mechanical Performance of Nickel-titanium Archwires
The purpose of the present work is to compare the mechanical properties of commercially available NiTi orthodontic archwires lots. Superelastic (SE) and heat-activated (HA) NiTi archwires from two lots of six manufacturers (3M, GAC, Tp, Orthosource, Orthometric and Morelli) were partitioned into eleven groups (n=132) and tested under three-point bending test
Mat. Res.. Publicado em: 03/11/2015
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19. Comparative study of curcumin and curcumin formulated in a solid dispersion: Evaluation of their antigenotoxic effects
Abstract Curcumin (CMN) is the principal active component derived from the rhizome of Curcuma longa (Curcuma longa L.). It is a liposoluble polyphenolic compound that possesses great therapeutic potential. Its clinical application is, however, limited by the low concentrations detected following oral administration. One key strategy for improving the solubil
Genet. Mol. Biol.. Publicado em: 03/11/2015
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20. Mutações somáticas em pacientes jovens com câncer de mama e epitelial de ovário: revisão e metanálise
Resumo Objetivo: avaliar se mutações somáticas em câncer de mama e seroso de ovário estão associados com pacientes jovens. Métodos: com base no COSMIC, foram selecionados os cinco genes mais frequentes mutados em câncer de mama e seroso de ovário. Em seguida, realizou-se uma revisão sistemática no PubMed. Pacientes jovens foram classificadas com
Rev. Assoc. Med. Bras.. Publicado em: 2015-10
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21. Câncer pediátrico e síndrome de Li-Fraumeni/Li-Fraumeni- like: uma revisão para o pediatra.
Resumo Introdução: o câncer é a segunda principal causa de morte em crianças com idades entre 0 e 14 anos, correspondendo a cerca de 3% de todos os casos diagnosticados no Brasil. Um percentual significativo (5-10%) dos cânceres pediátricos são associados a síndromes hereditárias para câncer, incluindo Li-Fraumeni/Li-Fraumeni-like síndromes (LFS/
Rev. Assoc. Med. Bras.. Publicado em: 2015-06
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22. Método FAMACHA para detectar anemia clínica causada por Haemonchus contortus em cordeiros lactentes e ovelhas em lactação
Resumo: O controle das endoparasitoses gastrintestinais em pequenos ruminantes tem sido tradicionalmente realizado por meio do uso indiscriminado dos anti-helmínticos, porém essa prática tem resultado em grande pressão de seleção de parasitas resistentes. Métodos seletivos (ex: FAMACHA/FMC e contagem de ovos nas fezes/OPG) e que apresentem boa sensibi
Pesq. Vet. Bras.. Publicado em: 2015-06
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23. DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations
Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary cancer predisposition disorder. In Brazil, the p.R337H TP53 founder mutation causes the variant form of LFS, Li-Fraumeni-like syndrome. The occurrence of cancer and age of disease onset are known to vary, even in patients carrying the same mutation, and several mechanisms such as genetic an
Braz J Med Biol Res. Publicado em: 28/04/2015
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24. Unraveling Brazilian Indian population prostate good health: clinical, anthropometric and genetic features
Purpose To compare dietary, lifestyle, clinical, anthropometric, genetic and prostatic features of Brazilian Indians and non-Indians (Amazon). Methods 315 men, 228 Indians and 89 non-Indians, ≥40 years old were submitted to digital rectal examination, serum prostate specific antigen (PSA), testosterone, TP53 and GSTP1 genotyping, anthropometric, lifestyle
Int. braz j urol.. Publicado em: 2015-04