Tolerance Principle
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. Multiple genes contribute to anhydrobiosis (tolerance to extreme desiccation) in the nematode Panagrolaimus superbus
Abstract The molecular basis of anhydrobiosis, the state of suspended animation entered by some species during extreme desiccation, is still poorly understood despite a number of transcriptome and proteome studies. We therefore conducted functional screening by RNA interference (RNAi) for genes involved in anhydrobiosis in the holo-anhydrobiotic nematode Pan
Genet. Mol. Biol.. Publicado em: 06/11/2017
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2. Criação de empresas à luz do modelo de decisão effectuation: um estudo com mulheres empreendedoras no município de Currais Novos/RN
This study analysed the creation of businesses by entrepreneur women in the Currais Novos city, looking for verifying if they used making decision processes aligned to the Effectuation logic throughout the creation of their companies. To this, was accomplished a multiple cases and exploratory study, whit a qualitative approach of analyse, using the thematic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/09/2011
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3. Carnap and the nature of logic / Carnap e a natureza da lógica
In The Logical Syntax of Language (1937) R. Carnap develops his Principle of Tolerance in Logic. This is a far-reaching principle for the whole philosophy of logic, and which sums up Carnaps most consistent tenets concerning the philosophical meaning of research in formal logic. Despite the failure of the general project of a syntactical philosophy, the Prin
Publicado em: 2010
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4. Os perpétuos e os incompletos: permanência e movimento nos gibis de super-heróis e na série Sandman
This thesis analyzes the fictional narratives of the comics books series Sandman, written by the British author Neil Gaiman, originally published by DC Comics and, in Brazil, by Globo, from 1989 to 1996, noting the translation and appropriation of elements from different cultural contexts for the construction of the narrative, in order to demonstrate that Sa
Publicado em: 2010
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5. Obtention of human pancreatic islets for transplantation through an increase in cell mass and an immunoisolation with biocompatible microcapsules / Ilhotas pancreáticas humanas viáveis para o transplante através do aumento da massa de células e do imunoisolamento com microcápsulas biocompatíveis
Islet transplantation has been proposed as a promising therapeutic strategy for the cure of type 1 diabetes mellitus (DM), however, its application to all diabetic patients is still not possible due to the limited source of islets or β cells and to the need of an immunosuppressive treatment of the recipient to avoid graft rejection. The use of immunosup
Publicado em: 2009
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6. Justiça distributiva: uma leitura da obra de John Rawls
A fairer income distribution has been debated as a way of making viable the democratic societies with liberal characteristics. The problem to be examined in this investigation is exatly the possibilities that the governments called liberal have, promoting reforms that result in such possibilities. In this way, we will be giving focus on the work A theory of
Publicado em: 2008
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7. Lipid A-induced tolerance and hyperreactivity to hypothermia in mice.
Mice responded to lipopolysaccharide (LPS) with a dose-dependent, monophasic hypothermia reaching a maximum at 2 h postinjection. Degraded polysaccharide was not active; free lipid A, however, induced a similar pattern of hypothermia, indicating that the hypothermic principle of LPS was embedded within the lipid A component. The hypothermic response of mice
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8. Inverse relationship between the susceptibility of lipopolysaccharide (lipid A)-pretreated mice to the hypothermic and lethal effect of lipopolysaccharide.
Mice pretreated (day 0) by a single injection of lipopolysaccharide (LPS) responded with hypothermic tolerance to (LPS) challenge on day 1 and with hypothermic hyperreactivity to LPS challenge on day 4. Reciprocally, mice pretreated similarly but with a higher challenge dose were hyperreactive with respect to LPS lethality on day 1, but highly tolerant to le
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9. Mixed chimerism induced without lethal conditioning prevents T cell– and anti-Galα1,3Gal–mediated graft rejection
Galα1,3Gal–reactive (Gal-reactive) antibodies are a major impediment to pig-to-human xenotransplantation. We investigated the potential to induce tolerance of anti-Gal–producing cells and prevent rejection of vascularized grafts in the combination of α1,3-galactosyltransferase wild-type (GalT+/+) and deficient (GalT–/–) mice. Allogeneic (H-2 mismat
American Society for Clinical Investigation.
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10. The hepoxilins and some analogues: a review of their biology
The hepoxilin pathway was discovered over two decades ago. Products in this pathway are derived through the 12S-lipoxygenase/hepoxilin synthase enzyme system and contain intrinsic biological activity. This activity relates to the reorganization of calcium and potassium ions within the cell, and in inflammation and insulin secretion. Although the natural hepo
Blackwell Publishing Ltd.
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11. Detection of Clostridium botulinum type A toxin by enzyme-linked immunosorbent assay with antibodies produced in immunologically tolerant animals.
Immunological tolerance is a state of unresponsiveness to foreign substances (antigens) which can develop in human and animal species as the result of continued exposure to antigens early in life. We utilized this principle for the preparation of antibodies against Clostridium botulinum type A toxin. By selective suppression of the immunological response of
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12. Gene Therapy Applications to Cancer Treatment
Over the past ten years significant advances have been made in the fields of gene therapy and tumour immunology, such that there now exists a considerable body of evidence validating the proof in the principle of gene therapy based cancer vaccines. While clinical benefit has so far been marginal, data from preclinical and early clinical trials of gene therap
Hindawi Publishing Corporation.