Tissue Inhibitor Of Metalloproteinases
Mostrando 13-24 de 95 artigos, teses e dissertações.
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13. Expression of type I collagen, MMP-2, MMP-8, MMP-14 and TIMPS in the periodontal ligament of rat incisors in normal and altered functional conditions / Expressão de colageno tipo I, MMP-2, MMP-8, MMP-14 eTIMPS no ligamento periodontal de incisivos de ratos em condições funcionais normal e alteradas
Periodontal ligament is a connective tissue that provides anchorage and support to the tooth, and it has a probable role in the tooth eruption. The extracelular matrix consists predominantly of collagen type I (Col-1) and the turnouver of collagen fibers is intense. Matrix metalloproteinases (MMPs) are members of a family of enzymes capable to degrade almost
Publicado em: 2008
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14. TIMP-1 mediates the inhibitory effect of interleukin-6 on the proliferation of a hepatocarcinoma cell line in a STAT3-dependent manner
The tissue inhibitor of metalloproteinases (TIMP)-1 is a multifunctional protein which is not only an inhibitor of matrix metalloproteinases (MMPs) but also to have a possible "cytokine-like" action. Here, we first compared mRNA expression of TIMP-1 and MMP-9 in BEL-7402 (a hepatocellular carcinoma cell line), L-02 (a normal liver cell line) and QSG-7701 (a
Brazilian Journal of Medical and Biological Research. Publicado em: 14/03/2007
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15. Desenvolvimento osseo e dentario : aspectos biologicos, bioquimicos e moleculares da remodelação da matriz extracelular regulada pelas metaloproteinases de matriz e seus inibidores / Dental and bone development : biology, biochemistry, and molecular aspects of the matrix metalloproteinases and their inhibitors during extracellular matrix remodeling
Our objective was to analyse the spatial-temporal distribution of MMP-2, MMP-9, TIMP-1, TIMP-2 and RECK during development of mineralized tissue (bone, enamel, and dentine) in embryos, newborn, and adult mice by immunohistochemistry and in situ hybridization. During rat amelogenesis, at the secretion phase, MMPs and RECK were immunostained in the ameloblast
Publicado em: 2007
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16. Efeito da inibição da clivagem do fator de necrose tumoral (TNF) em modelo de isquemia e reperfusão intestinal
TNF-á plays an important role in reperfusion-induced tissue injury and lethality. Here, we assessed the effect of PKF242-484 and PKF241-466, two dual inhibitors of TNF-á converting enzyme (TACE) and matrix metalloproteinases (MMPs). We examine the role of these enzymes modulating TNF-á levels in tissue and serum after ischemia and reperfusion of the super
Publicado em: 2007
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17. "Expressão das metaloproteinases MMP-2, MT1-MMP e TIMP-2 e aspectos clinicopatológicos no carcinoma medular da glândula tireóide: implicações prognósticas" / Expression of matrix metalloproteinases MMP-2, TIMP-2 e MT1-MMP and clinicopathologic aspects in medullary thyroid carcinoma: prognostic implications
Metalloproteinases (MMP) are proteolytic enzymes, fundamental to carcinogenesis. Outcome of 37 patients operated on due to medullary thyroid carcinomas were compared to clinicopathologic data and immunohistochemistry expression of MMP-2, MT1-MMP and TIMP-2 in their neoplastic specimens. Final clinical conditions were related to the clinicopathologic aspects:
Publicado em: 2006
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18. Tissue modifications and expression of matrix metalloproteinases and the inhibitor Reck in the progression of periodontal disease induced in rats / Modificações teciduais e expressão de metalproteinases de matriz e do inibidor Reck na progressão da doença periodontal induzida em ratos
A doença periodontal é a patologia crônica de maior incidência na dentição humana. A placa bacteriana é seu agente etiológico principal, embora uma resposta imune exacerbada seja apontada como fator preponderante para o agravamento das lesões. Já nos primeiros estágios da doença é possível notar uma grande degradação da matriz extracelular lo
Publicado em: 2006
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19. Macrophage elastase (MMP-12): a pro-inflammatory mediator?
As many metalloproteinases (MMPs), macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling processes. Studies using animal models of acute and chronic pulmonary inflammatory diseases, such as pulmonary fibrosis and chronic obstrutive pulmonary disease (COPD), have given evidences th
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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20. Análise da expressão diferencial de genes do folículo ovariano de fêmeas pré-púberes e púberes Bos primigenius indicus (Nelore) por meio da Análise Serial de Expressão Gênica (SAGE) / Analysis of differential gene expression of ovarian follicle from prepubertal and pubertal Bos primigenius indicus (Nelore) females by Serial Analysis of Gene Expression (SAGE)
Puberty is the stage where any mammal, male or female, becomes able to produce viable gametes and manifest complete sexual behavior. These are results from the gradative adjustment between the increase in gonadotrophic activity and the ability of gonads in undergoing simultaneously both steroidogenesis and gametogenesis. One of the major factors interferring
Publicado em: 2005
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21. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones.
Matrix metalloproteinases are a highly regulated family of enzymes, that together can degrade most components of the extracellular matrix. These proteins are active in normal and pathological processes involving tissue remodeling; however, their sites of synthesis and specific roles are poorly understood. Using in situ hybridization, we determined cellular d
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22. Basic FGF mediates an immediate response of articular cartilage to mechanical injury
The extracellularly regulated kinase (ERK), one of the three types of mitogen-activated kinases, was rapidly activated after cutting porcine articular cartilage either when maintained as explants or in situ. Cutting released a soluble ERK-activating factor from the cartilage, which was purified and identified by MS as basic fibroblast growth factor (bFGF). E
The National Academy of Sciences.
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23. In vivo suppression of immune complex-induced alveolitis by secretory leukoproteinase inhibitor and tissue inhibitor of metalloproteinases 2.
The pulmonary tree is exposed to neutrophil-derived serine proteinases and matrix metalloproteinases in inflammatory lung diseases, but the degree to which these enzymes participate in tissue injury remains undefined, as does the therapeutic utility of antiproteinase-based interventions. To address these issues, an in vivo rat model was examined in which the
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24. Tissue inhibitor of metalloproteinases-2 is expressed in the interstitial matrix in adult mouse organs and during embryonic development.
Tissue inhibitor of metalloproteinases-2 (TIMP-2) is a member of a family of inhibitors of matrix-degrading metalloproteinases. A better insight into the role of this inhibitor during development and in organ function was obtained by examining the temporospatial expression of TIMP-2 in mice. Northern blot analysis indicated high levels of TIMP-2 mRNA in the