"Expressão das metaloproteinases MMP-2, MT1-MMP e TIMP-2 e aspectos clinicopatológicos no carcinoma medular da glândula tireóide: implicações prognósticas" / Expression of matrix metalloproteinases MMP-2, TIMP-2 e MT1-MMP and clinicopathologic aspects in medullary thyroid carcinoma: prognostic implications

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Metalloproteinases (MMP) are proteolytic enzymes, fundamental to carcinogenesis. Outcome of 37 patients operated on due to medullary thyroid carcinomas were compared to clinicopathologic data and immunohistochemistry expression of MMP-2, MT1-MMP and TIMP-2 in their neoplastic specimens. Final clinical conditions were related to the clinicopathologic aspects: clinical features, systemic symptoms, tumor size, tumor extension to thyroid capsule, tumor extension to adjacent tissues, vascular invasion, cervical metastases, TNM stage and evidences of disease in the neck and/or distant metastases. Expression of MMP-2 and MT1-MMP were related to outcome and greater proportion of TIMP-2, over MMP-2, was related to prognostic benefits

ASSUNTO(S)

carcinoma medullary gelatinase a carcinoma medular metalloproteases imunohistoquímica neoplasias da glândula tireóide prognóstico prognosis immunohistochemistry tissue inhibitor of metalloproteinase-2 gelatinase a thyroid neoplasms metaloproteases inibidor de metaloproteinase-2 tecidual

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