Tissue Inhibitor Of Metalloproteinase 2
Mostrando 1-12 de 56 artigos, teses e dissertações.
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1. Evaluating TIMP-2 and IGFBP-7 as a predictive tool for kidney injury in ureteropelvic junction obstruction
ABSTRACT A major challenge in the management of ureteropelvic junction obstruction (UPJO) is the selection of patients who would benefit from surgical treatment. Tissue inhibitor metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) indicate renal cell stress and are associated with cell cycle arrest. The [TIMP-2] [IGFBP7] ra
International braz j urol. Publicado em: 2022
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2. Is the Expression of the Components of the Carotid Matrix of Rats Influenced by Estrogen, Progestin and Tibolone?
Resumo Objetivo Analisar os efeitos do estrogênio isolado ou em combinação com progestogênios e tibolona (TIB) na expressão das metaloproteinases 2 e 9 da matriz extracelular (MMP-2 e MMP-9), da perlecan e da heparanase (HPSE) das paredes vasculares das artérias carótidas. Métodos Trinta ratas Wistar ovariectomizadas com 250 dias de idade foram t
Rev. Bras. Ginecol. Obstet.. Publicado em: 15/08/2019
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3. ImunoexpressÃo de metaloproteinases 2 e 14 e do inibidor TIMP-2 no cÃncer colorretal / Immunoexpression of metalloproteinases 2 and 14 and the inhibitor TIMP-2 in colorectal cancer
O cÃncer colorretal(CCR) Ã altamente prevalente nos paÃses mais ricos e industrializados. As metaloproteinases de matriz (MMPs) sÃo importantes enzimas que facilitam a invasÃo e disseminaÃÃo do tumor em vÃrios tipos de cÃncer, inclusive o colorretal. Os inibidores teciduais de metaloproteinases (TIMPs) sÃo os principais inativadores fisiolÃgicos d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2012
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4. Associação entre haplótipos de metaloproteinase-9 de matriz extracelular (MMP-9) e obesidade infantil : efeitos sobre a concentração plasmática de MMP-9 / Association between haplotypes of matrix metalloproteinase-9 extracellular matrix (MMP-9) and childhood obesity : effects on plasma concentration of MMP-9
The childhood obesity is important risk factor for cardiovascular diseases, in particular, atherosclerose. This condition is characterized by the accumulation of lipids and fibrous elements in the large arteries in which inflammatory mechanisms and vascular remodeling are involved. In this context, matrix metalloproteinase 9 (MMP-9) - endopeptidade capable o
Publicado em: 2011
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5. Expression of type I collagen, MMP-2, MMP-8, MMP-14 and TIMPS in the periodontal ligament of rat incisors in normal and altered functional conditions / Expressão de colageno tipo I, MMP-2, MMP-8, MMP-14 eTIMPS no ligamento periodontal de incisivos de ratos em condições funcionais normal e alteradas
Periodontal ligament is a connective tissue that provides anchorage and support to the tooth, and it has a probable role in the tooth eruption. The extracelular matrix consists predominantly of collagen type I (Col-1) and the turnouver of collagen fibers is intense. Matrix metalloproteinases (MMPs) are members of a family of enzymes capable to degrade almost
Publicado em: 2008
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6. "Expressão das metaloproteinases MMP-2, MT1-MMP e TIMP-2 e aspectos clinicopatológicos no carcinoma medular da glândula tireóide: implicações prognósticas" / Expression of matrix metalloproteinases MMP-2, TIMP-2 e MT1-MMP and clinicopathologic aspects in medullary thyroid carcinoma: prognostic implications
Metalloproteinases (MMP) are proteolytic enzymes, fundamental to carcinogenesis. Outcome of 37 patients operated on due to medullary thyroid carcinomas were compared to clinicopathologic data and immunohistochemistry expression of MMP-2, MT1-MMP and TIMP-2 in their neoplastic specimens. Final clinical conditions were related to the clinicopathologic aspects:
Publicado em: 2006
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7. Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
Phosphodiesterases (PDEs) are responsible for the breakdown of intracellular cyclic nucleotides, from which PDE4 are the major cyclic AMP metabolizing isoenzymes found in inflammatory and immune cells. This generated greatest interest on PDE4 as a potential target to treat lung inflammatory diseases. For example, cigarette smoke-induced neutrophilia in BAL w
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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8. Identification of tissue inhibitor of metalloproteinase-2 (TIMP-2)-progelatinase complex as the third metalloproteinase inhibitor peak in rheumatoid synovial fluid.
The metalloproteinases are a family of enzymes that can degrade all the components of the extracellular matrix. These potent enzymes are often found in proenzyme forms and require activation before the substrate can be digested. To prevent unlimited connective tissue destruction a number of inhibitors exist to limit their activity. In a previous study it was
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9. Tissue Inhibitor of Metalloproteinase 1 Regulates Resistance to Infection
Tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that M
American Society for Microbiology.
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10. cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.
The purification and characterization of a metalloproteinase inhibitor (MI) from bovine aortic endothelial cells, and the demonstration that it is related to, but distinct from, tissue inhibitor of metalloproteinase (TIMP), have previously been reported [De Clerck, Y. A., Yean, T.-D., Ratzkin, B. J., Lu, H.S. & Langley, K. E. (1989) J. Biol. Chem. 264, 17445
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11. Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros
Development of the embryonic kidney results from reciprocal signaling between the ureteric bud and the metanephric mesenchyme. To identify the signaling molecules, we developed an assay in which metanephric mesenchymes are rescued from apoptosis by factors secreted from ureteric bud cells (UB cells). Purification and sequencing of one such factor identified
American Society for Clinical Investigation.
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12. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones.
Matrix metalloproteinases are a highly regulated family of enzymes, that together can degrade most components of the extracellular matrix. These proteins are active in normal and pathological processes involving tissue remodeling; however, their sites of synthesis and specific roles are poorly understood. Using in situ hybridization, we determined cellular d