Thyroid Neoplasms
Mostrando 25-36 de 47 artigos, teses e dissertações.
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25. InteraÃÃo da frutalina com neoplasias de tireÃide. Estudo comparativo com marcadores tumorais em uso / FRUTALIN AS A TUMORAL MARKER IN THYROID LESIONS. A COMPARATIVE STUDY WITH ROUTINELY USED MARKERS.
O interesse nos carboidratos de superfÃcie celular tem aumentado devido ao fato de estarem relacionados a diferenciaÃÃo e maturaÃÃo celular. A transformaÃÃo celular em neoplasias malignas està associado a alteraÃÃes na superfÃcie de membranas celulares, particularmente na composiÃÃo dos glicoconjugados, determinando sua capacidade em relaÃÃo a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/09/2008
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26. Expressão do simportador sódio-iodo (NIS) nos tumores tireoidianos benignos e malignos através de estudo imunohistoquímico e da quantificação do RNA mensageiro / Expression of the sodium iodide symporter (NIS) in benign and malignant thyroid tumors using immunohistochemistry and mesenger RNA quantification
The iodide uptake by epithelial thyroid cells requires the expression of sodium iodide symporter (NIS), a transmembrane glycoprotein of 643 amino acids. NIS is located at basolateral plasma membrane of the thyroid follicular cells and couples the transport of iodide and sodium to this cells. NIS gene was cloned in 1996, being the first step of investigation
Publicado em: 2007
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27. Impact of diet and glutathione s-transferase system genotype in the susceptibility to cancer / Impacto do perfil alimentar e genotipico do sistema glutationa S-transferase na susceptibilidade ao cancer
Background: Glutathione-S-Transferase gene family has an important role in the biotransformation and detoxification of different xenobiotics and endogenous compounds. The high admixture of the Brazilian population may represent a unique model in which the types and frequency of genetic polymorphisms of GST enzymes are less influenced by ethnicity. Objective:
Publicado em: 2007
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28. Impacto do perfil alimentar e genotipico do sistema glutationa S-transferase na susceptibilidade ao cancer / Impact of diet and glutathione s-transferase system genotype in the susceptibility to cancer
Background: Glutathione-S-Transferase gene family has an important role in the biotransformation and detoxification of different xenobiotics and endogenous compounds. The high admixture of the Brazilian population may represent a unique model in which the types and frequency of genetic polymorphisms of GST enzymes are less influenced by ethnicity. Objective:
Publicado em: 2007
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29. "Expressão das metaloproteinases MMP-2, MT1-MMP e TIMP-2 e aspectos clinicopatológicos no carcinoma medular da glândula tireóide: implicações prognósticas" / Expression of matrix metalloproteinases MMP-2, TIMP-2 e MT1-MMP and clinicopathologic aspects in medullary thyroid carcinoma: prognostic implications
Metalloproteinases (MMP) are proteolytic enzymes, fundamental to carcinogenesis. Outcome of 37 patients operated on due to medullary thyroid carcinomas were compared to clinicopathologic data and immunohistochemistry expression of MMP-2, MT1-MMP and TIMP-2 in their neoplastic specimens. Final clinical conditions were related to the clinicopathologic aspects:
Publicado em: 2006
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30. "Predição do risco de metástase do carcinoma bem diferenciado da glândula tireóide pela quantificação digital da imunoexpressão da galectina-3 nos compartimentos do tireócito maligno" / Prediction of metastasis risk in well-differentiated thyroid carcinoma based on digital quantification of galectin-3 immunoexpression in subcellular compartments of the malignant thyrocyte
INTRODUCTON: Papillary and follicular carcinomas are primary malignant neoplasias of the thyroid gland and are classified as well-differentiated carcinoma. In these cases, determination of individual risk of metastasis allows offering an adequate treatment. Nowadays therapy is chosen based on classification according to prognostic factors and biomarkers can
Publicado em: 2006
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31. Contribution to the prognostic assessment of patients with advanced lung adenocarcinoma: evaluation by immunohistochemical methods of thyroid transcription factor-1 and matrix metalloproteinase-9 / "Contribuição à avaliação prognóstica de pacientes com adenocarcinoma pulmonar avançado: estudo imunohistoquímico da expressão do fator 1 de transcrição tireoideano e da metaloproteinase 9"
O valor prognóstico da expressão do Fator 1 de Transcrição Tireoideano (TTF-1) e da metaloproteinase-9 (MMP-9) foi avaliado em 51 pacientes com adenocarcinoma pulmonar avançado. Foram fatores de mau prognóstico: baixa capacidade funcional (P = 0,017), baixa expressão do TTF-1 (P = 0,001) e alta expressão da MMP-9 (P = 0,008). Identificaram-se três g
Publicado em: 2005
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32. Lack of mutations of exon 2 of the MEN1 gene in endocrine and nonendocrine sporadic tumors
In addition to the mutations that underlie most cases of the multiple endocrine neoplasia type 1 (MEN1) syndrome, somatic mutations of the MEN1 gene have also been described in sporadic tumors like gastrinomas, insulinomas and bronchial carcinoid neoplasm. We examined exon 2 of this gene, where most of the mutations have been described, in 148 endocrine and
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-07
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33. Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.
We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carci
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34. Hürthle cell neoplasms of the thyroid: are there factors predictive of malignancy?
OBJECTIVE: To determine if any preoperative or intraoperative factors can reliably predict malignancy in patients with Hürthle cell neoplasms. SUMMARY BACKGROUND DATA: Most experienced surgeons recommend total thyroidectomy for Hürthle cell carcinomas and reserve thyroid lobectomy for Hürthle cell adenomas. However, delineation between Hürthle cell adeno
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35. Medullary carcinoma of the thyroid with carcinoid-like features.
AIMS: To show that medullary carcinomas of the thyroid are morphologically indistinguishable from gut carcinoids: the value of histochemistry in their identification and differential diagnosis from metastatic carcinoid tumours to the thyroid and some follicular cell neoplasms. METHODS: 15 thyroid medullary carcinomas with features of gut carcinoids were hist
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36. Clonal composition of benign and malignant human thyroid tumors.
We determined clonality of thyroid tumors from female patients who had restriction fragment length polymorphisms (RFLP) in the X chromosome genes hypoxanthine phosphoribosyltransferase (HPRT) or phosphoglycerate kinase (PGK). We screened normal thyroid tissue from 59 female patients; of the informative cases 14 were heterozygous for a Bgl I site on PGK and 4