Thymus Gland
Mostrando 25-36 de 68 artigos, teses e dissertações.
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25. Purification and Biological Activity of Thymosin, a Hormone of the Thymus Gland
The purification and chemical properties of thymosin, obtained from bovine thymus tissue, are described. The biological activity of the thymic hormone has been assessed by a newly developed rosette assay, which permits measurement of thymus-dependent lymphoid cells. Thymosin activity is associated with a physico-chemically homogeneous protein of molecular we
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26. Continuous darkness and continuous light induce structural changes in the rat thymus.
It is known that neuroendocrine responses to environmental stimuli, such as light, can influence immune responses through the pineal gland. It is also known that periods of constant darkness and constant light cause stimulation and inhibition of melatonin secretion from the pineal gland, successively. In this study, we provide experimental evidence that chan
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27. Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice.
Previous studies in our laboratory have demonstrated the mammary-specific expression of the entire rat beta-casein gene with 3.5 kilobases (kb) of 5' and 3.0 kb of 3' DNA in transgenic mice (Lee et al., Nucleic Acids Res. 16:1027-1041, 1988). In an attempt to localize sequences that dictate this specificity, lines of transgenic mice carrying two different ra
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28. Lymphocyte subpopulations in thymus and blood from patients with myasthenia gravis.
Cell suspensions were prepared from hyperplastic thymic tissue and lymphoepithelioma from patients with myasthenia gravis and from presumed normal thymic tissue obtained at cardiac surgery. The mononuclear cells were examined for surface markers. The mean percentages of both T lymphocytes and Fc receptor-carrying lymphocytes were similar in the three groups,
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29. Deoxynucleotide-Polymerizing Enzymes of Calf Thymus Gland, IV. Inhibition of Terminal Deoxynucleotidyl Transferase by Metal Ligands*
The polymerization of deoxynucleoside triphosphates, catalyzed by terminal deoxynucleotidyl transferase from calf thymus gland, is strongly inhibited by various metal chelators. The reaction appears to be first order with respect to enzyme, deoxynucleoside triphosphate, and initiator, indicating that there is only one catalytic center for each enzyme molecul
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30. Carcinoid tumour of possible thymic origin: case report.
A case of carcinoid tumour of possible thymic origin in a 43-year-old man is presented. Carcinoid tumour arising in the anterior mediastinum (thymus) is a rare condition and only 26 cases have been reported in the past. A review of the literature showed that three-quarters of the reported cases were asymptomatic but the remainder of patients presented with v
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31. Pineal Protein Kinase: Effect of Enzymic Phosphorylation on Actinomycin D Binding by, and Template Activity of, Chromatin
The ability of protein kinase from bovinepineal gland to phosphorylate calf-thymus chromatin and thereby to alter the association between chromatin DNA and histones was investigated. Phosphorylation of calf-thymus chromatin by pineal protein kinase results in an apparent decreased binding between the histones and DNA in chromatin, as indicated by (i) an incr
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32. Translation of mRNA from calf thymus in the wheat germ system: evidence for a precursor of thymosin alpha1.
When translated in the wheat germ system, mRNA from fresh calf thymus stimulates incorporation of radioactive amino acids into an acid-insoluble product, and 10--20% of the total radioactivity incorporated is precipitated with antisera to active thymosin fractions. In sodium dodecyl sulfate disc gel electrophoresis, radioactivity was recovered mainly in two
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33. Prolactin increases CD4/CD8 cell ratio in thymus-grafted congenitally athymic nude mice.
One distinctive effect on T-cell development was analyzed by selectively increasing serum prolactin (PRL) concentration in thymus-grafted congenitally athymic nude mice and by neutralizing PRL in suspension cultures of thymus from 1-day-old neonatal mice. Flow cytometric analysis of single-positive CD4+ and CD8+ cells derived from inguinal lymph nodes reveal
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34. The weight of the human thymus gland at necropsy.
The wet, lipid and lean dry weights of 574 thymus glands from Coroner's necropsies were examined for age-related changes. Despite enormous variation in wet and lipid weights at all ages there was a gradual decrease in wet weight with age and a significant increase in lipid weight until 40--50 years of age, with little change thereafter. There was a small dec
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35. Antibody to terminal deoxynucleotidyl transferase.
Antibody to homogeneous terminal deoxynucleotidyl transferase (EC 2.7.7.31, nucleoside triphosphate: DNA deoxynucleotidylexotransferase) from calf thymus gland has been prepared using crosslinked antigen derivatives in rabbits. The antisera produced precipitate and neutralize homologous antigen, and crossreact with human, chicken, mouse, and rat terminal tra
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36. The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system
In the mouse, the product of the nude locus, Whn, is required for the keratinization of the hair shaft and the differentiation of epithelial progenitor cells in the thymus. A bacterially expressed peptide representing the presumptive DNA binding domain of the mouse whn gene in vitro specifically binds to a 11-bp consensus sequence containing the invariant te
The National Academy of Sciences of the USA.