Thymic Atrophy
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. Fibronectin modulates thymocyte-thymic epithelial cell interactions following Trypanosoma cruzi infection
Developing thymocytes interact with thymic epithelial cells (TECs) through cell-cell interactions, TEC-derived secretory moieties and extracellular matrix (ECM)-mediated interactions. These physiological interactions are crucial for normal thymocyte differentiation, but can be disrupted in pathological situations. Indeed, there is severe thymic atrophy in an
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-11
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2. Thymic microenvironmental alterations in different kind of thymus atrophy / Aterações no microambiente timico frente a diferentes agentes indutores de atrofia
Thymus is the primary lymphoid organ responsible for differentiation of Tlymphocytes. This process is dependent of thymic microenvironment integrity and coordinated migration of hematopoietic precursors by chemokines and extracellular matrix elements. However, the literature shows that deep alterations in thymus microenvironment with modifications in thymocy
Publicado em: 2009
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3. Comprometimento timico em tres diferentes modelos experimentais de atrofia timica : alterações celulares e de citocinas / Thymic cells and cytokines alterations in different kind of thymus atrophy
O timo é o órgão linfóide primário onde os precursores de células T, chamados de timócitos, sofrem processos de diferenciação, seleção e proliferação. Todos estes processos são seqüencialmente dependentes de distintos microambientes no interior do órgão delimitados morfológica e fenotipicamente. Por isso a manutenção do microambiente é e
Publicado em: 2009
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4. Análise de células CD4+CD25+FoxP3+ no timo de camundongos infectados pelo Trypanosoma cruzi. / Analysis of cells CD4 CD25 FoxP3 in the thymus of mice infected for the Trypanosoma cruzi.
Natural regulatory T cells arise in the thymus during the normal process of differentiation and participate in the control of auto and alloimmune responses. Specifically in parasite infections, these cells may have antagonist roles, in favor of the microorganism or the host. Previous studies from our Laboratory revealed that acute Trypanosoma cruzi (T. cruzi
Publicado em: 2008
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5. Peripubertal orchidectomy transitorily affects age-associated thymic involution in rats
The role of gonadal hormones in induction and, particularly, maintenance/progression of rat thymic involution, which normally starts around puberty, was reassessed by examining the effects of peripubertal orchidectomy on thymic weight and morphometric parameters at different times up to the age of 10 months. Up to 6 months post-castration both thymic weight
Brazilian Journal of Medical and Biological Research. Publicado em: 22/10/2007
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6. Atrofia timica na paracoccidioidomicose experimental : influencia da virulencia fungica, da linhagem murina e de citocinas pro-inflamatorias / Thymic atrophy during experimental paracoccidioidomycosis : influence of fungal virulence, murine strain and pro-inflammatory cytokines
Thymus is the site of T cells maturation that orchestrates specific immune response following antigen recognition. In spite of this, it can be a target during many infectious diseases. Paracoccidioides brasiliensis, the etiological agent of paracoccidioidomycosis, is able to invade the thymus inducing atrophy in experimental models. In this study, it was ana
Publicado em: 2005
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7. In vivo induction of apoptosis in the thymus by administration of mycobacterial cord factor (trehalose 6,6'-dimycolate).
It is reported that some bacteria or bacterial components cause thymic atrophy via the apoptotic process. The present study demonstrated for the first time in vivo induction of apoptosis in the mouse thymus by mycobacterial cord factor (CF) (trehalose 6,6'-dimycolate). When 300 microg of purified CF from Mycobacterium tuberculosis was intravenously administe
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8. Alteration from T- to B-cell tropism reduces thymic atrophy and cytocidal effects in thymocytes but not neurovirulence induced by ts1, a mutant of Moloney murine leukemia virus TB.
The ts1 mutant of Moloney murine leukemia virus TB causes degenerative neurologic and immunologic disease in mice, characterized by development of spongiform encephalomyelopathy resulting in hindlimb paralysis, marked thymic atrophy associated with immunodeficiency, and generalized body wasting. To investigate the pathogenesis of the thymic atrophy caused by
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9. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
Thymic atrophy is a prominent feature of malnutrition. Forty-eight hours’ starvation of normal mice reduced the total thymocyte count to 13% of that observed in freely fed controls, predominantly because of a diminution in the cortical CD4+CD8+ thymocyte subpopulation. Prevention of the fasting-induced fall in the level of the adipocyte-derived hormone lep
American Society for Clinical Investigation.
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10. Moloney Murine Leukemia Virus-Induced Preleukemic Thymic Atrophy and Enhanced Thymocyte Apoptosis Correlate with Disease Pathogenicity
Moloney murine leukemia virus (M-MuLV) is a replication-competent, simple retrovirus that induces T-cell lymphoma with a mean latency of 3 to 4 months. During the preleukemic period (4 to 10 weeks postinoculation) a marked decrease in thymic size is apparent for M-MuLV-inoculated mice in comparison to age-matched uninoculated mice. We were interested in stud
American Society for Microbiology.
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11. Immunodepression Induced by Trypanosoma cruzi and Mouse Hepatitis Virus Type 3 Is Associated with Thymus Apoptosis
Trypanosoma cruzi-infected mice show disturbance in the peripheral immune system such as polyclonal lymphocyte activation, autoantibody production, and immunosuppression of T lymphocytes. Previous observations in our laboratory showed that some stocks of T. cruzi can be contaminated with mouse hepatitis virus type 3 (MHV-3). Literature has shown that MHV-3 i
American Society for Microbiology.
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12. Experimental Parainfluenzavirus Infection in Mice: Fatal Illness with Atrophy of Thymus and Spleen in Mice Caused by a Variant of Parainfluenza 3 Virus
Intracerebral inoculation of the YN strain of parainfluenza 3 virus was found to induce an acute fatal illness characterized by marked thymic and splenic atrophy in newborn mice. Previously we showed that the YN strain contains three distinct plaque-type variants, LT, SC, and M. Of these, the M-type variant induced this fatal illness, whereas the other two v