Thymic microenvironmental alterations in different kind of thymus atrophy / Aterações no microambiente timico frente a diferentes agentes indutores de atrofia

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Thymus is the primary lymphoid organ responsible for differentiation of Tlymphocytes. This process is dependent of thymic microenvironment integrity and coordinated migration of hematopoietic precursors by chemokines and extracellular matrix elements. However, the literature shows that deep alterations in thymus microenvironment with modifications in thymocyte development may occur such as result of some pathological disorders. In this study we analyzed the atrophy induction and alterations in thymic microenvironment in three different models of thymus atrophy. We studied two models of infectious diseases, P.brasiliensis and P.berghei, and a metabolic disorder, alloxan induced diabetes. We have observed thymus atrophy in all models with different alterations levels in thymus microenvironment elements. Important molecules associated with intrathymic migration were been altered with significant modifications in extracellular matrix elements, chemokines and their specific receptors. Besides, ex vivo migration was altered in thymus atrophy induced by pathogenic agents, but no alterations were observed in diabetic mice suggesting that different pathological conditions studied, leads to singular alterations in thymus compartment. The modifications in thymic molecules observed in our models, suggest impaired thymus functionality and alterations in thymocyte migration patterns These alterations can lead T cell maturation imbalance with consequences in Tlymphocyte immune response

ASSUNTO(S)

matriz extracelular extracellular matrix timo paracoccidioidomycosis paracoccidioidomicose malaria thymus thymic atrophy atrofia timica malaria

ACESSO AO ARTIGO

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