Thiazolidinone
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Combretastatin A-4: The Antitubulin Agent that Inspired the Design and Synthesis of Styrene and Spiroisatin Hybrids as Promising Cytotoxic, Antifungal and Antiviral Compounds
The design of a series of styrene and spiroisatin hybrids was based on the structure of combretastatin A-4 1. This library of 20 compounds were synthesized with the pharmacophoric units: 3,4,5-trimethoxy or/and 4-hydroxy-3-methoxy phenyl moities in their structure. Thereby, the libraries of β-nitrostyrenes 10a-10c, spiroisatin-dihydroquinolines 14a-14c, spi
J. Braz. Chem. Soc.. Publicado em: 2020-05
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2. Synthesis, Anti-Diabetic and Renoprotective Activity of Some New Benzazole, Thiazolidin-4-one and Azetidin-2-one Derivatives
A new series of benzazole, thiazolidinone and azetidin-2-one derivatives incorporating to pyrazole moiety were synthesized by condensation of 1,3-diphenyl-1H-pyrazol-4-carboxaldehyde with different nucleophiles. The structures of the newly synthesized compounds were confirmed by analytical and spectral methods. Some of these compounds were evaluated for thei
J. Braz. Chem. Soc.. Publicado em: 2017-11
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3. Development and application of lc-uv method for the quantification of the anti-inflammatory thiazolidinone pg15 in rat plasma
Um método rápido e simples de cromatografia líquida com detecção por ultravioleta foi desenvolvido e validado para quantificação, em plasma de rato, do composto (5Z,E)-3-[2-(4-clorofenil)-2-oxoetil]-5-(1H-indol-3-ilmetileno)-tiazolidina-2,4-diona (PG15). Uma coluna em fase reversa C18 foi utilizada para separação do analito, seguida por detecção e
Publicado em: 2010
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4. Anti-parasitic action and elimination of intracellular Toxoplasma gondii in the presence of novel thiosemicarbazone and its 4-thiazolidinone derivatives
Toxoplasma, which infects all eukaryotic cells, is considered to be a good system for the study of drug action and of the behavior of infected host cells. In the present study, we asked if thiosemicarbazone derivatives can be effective against tachyzoites and which morphological and ultrastructural features of host cells and parasites are associated with the
Brazilian Journal of Medical and Biological Research. Publicado em: 06/11/2009
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5. Síntese e avaliação da atividade antimicrobiana de novas 4-tiazolidinonas obtidas a partir de formilpiridina tiossemicarbazonas
Twelve novel 4-thiazolidinone derivatives (2a-l) have been synthesized by reacting formilpyridine thiosemicarbazones (1a-l) and anhydride maleic in toluene. Their chemical structures were confirmed by IR, ¹H and 13C NMR. The new compounds were submitted to in vitro evaluation against pathogenic Gram-positive, Gram-negative bacteria and yeasts. The findings
Química Nova. Publicado em: 2009
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6. Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas
Molecules containing the 4-thiazolidinone ring are known to possess a wide range of biological properties including antimicrobial and anti-inflammatory activities among others. These compounds can be synthesized by cyclization reactions involving alpha-haloacetic acid or alpha-mercaptoacetic acid and employed in several chemoselective reactions. Comprehensiv
Química Nova. Publicado em: 2008
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7. Development and application of LC-UV method for the quantification of the anti-inflammatory thiazolidinone PG15 in rat plasma
Um método rápido e simples de cromatografia líquida com detecção por ultravioleta foi desenvolvido e validado para quantificação, em plasma de rato, do composto (5Z,E)-3-[2-(4-clorofenil)-2-oxoetil]-5-(1H-indol-3-ilmetileno)-tiazolidina-2,4-diona (PG15). Uma coluna em fase reversa C18 foi utilizada para separação do analito, seguida por detecção e
Journal of the Brazilian Chemical Society. Publicado em: 2008
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8. Novas Tiazolidinadionas 3, 5-Dissubstituidas: sÃntese, comprovaÃÃo estrutural e avaliaÃÃo da atividade antiinflamatÃria
To the thiazolidinic nucleus, due to their chemical reactivity, are atributed several biological activities, fact that directed our research in search of new biologically active agents. Recent studies have demonstrated the potential of thiazolidinics derivatives in inhibiting the inflammatory response, characterized by the release of various endogenous pro-i
Publicado em: 2008
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9. SÃntese e AvaliaÃÃo das Atividades Anti-Toxoplasma gondii e Antimicrobiana de BenzaldeÃdo 4-Fenil-3-tiossemicarbazonas e Derivados 2[(Fenilmetileno)hidrazono]-3-fenil-4-tiazolidinona-5-substituÃdos
Parasitic diseases, as toxoplasmosis, affect millions of people, and they are responsible for some of the most important and prevalent diseases of humans and domestic animals. These diseases result in considerable morbidity and mortality worldwide, especially in developing countries. The toxoplasmosis is caused by an intracellular parasite, Toxoplasma gondii
Publicado em: 2007
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10. SÃntese e avaliaÃÃo de atividades Anti-Toxoplama gondii e antimicrobiana de Tiossemicarbazidas, 4-Tiazolidinonas e 1,3,4-TiadiazÃis obidos a partir do Ãster 5-Metil-1H-Imidazol-4-Carboxilato de Etila
Toxoplasmosis is an infection caused by Toxoplasma gondii, a protozoan parasite with very complex biology and wide distribution in several geographical areas of the globe. In 2005, our research group published a paper reporting an exceptional anti-T. gondii activity for thiosemicarbazones and arylhydrazono-4-thiazolidinones, with a nitro group in aryl moiety
Publicado em: 2007
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11. Modifications of cellulose synthase confer resistance to isoxaben and thiazolidinone herbicides in Arabidopsis Ixr1 mutants
In many higher plants, cellulose synthesis is inhibited by isoxaben and thiazolidinone herbicides such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl) phenyl-4-thiazolidinone. Semidominant mutations at the IXR1 and IXR2 loci of Arabidopsis confer isoxaben and thiazolidinone resistance. Isolation of the IXR1 gene by map-based cloning revealed that it encode
The National Academy of Sciences.
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12. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion
Secretory diarrhea is the leading cause of infant death in developing countries and a major cause of morbidity in adults. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is required for fluid secretion in the intestine and airways and, when defective, causes the lethal genetic disease cystic fibrosis. We screened 50,000 chemically dive
American Society for Clinical Investigation.