Síntese e avaliação da atividade antimicrobiana de novas 4-tiazolidinonas obtidas a partir de formilpiridina tiossemicarbazonas
AUTOR(ES)
Verçoza, George Leonardo, Feitoza, Danniel Delmondes, Alves, Antônio José, Aquino, Thiago Mendonça de, Lima, José Gildo de, Araújo, Janete Magali, Cunha, Ivana Gláucia B., Góes, Alexandre José da Silva
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2009
RESUMO
Twelve novel 4-thiazolidinone derivatives (2a-l) have been synthesized by reacting formilpyridine thiosemicarbazones (1a-l) and anhydride maleic in toluene. Their chemical structures were confirmed by IR, ¹H and 13C NMR. The new compounds were submitted to in vitro evaluation against pathogenic Gram-positive, Gram-negative bacteria and yeasts. The findings obtained showed that the compounds 2a, 2d, 2e and 2g were effective against some of the bacterial strains used, whereas the compounds 2d, 2e and 2i exhibited a moderate antifungal activity against the yeast strains evaluated. An initial structure activity relationship (SAR) was established.
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