Therapeutics
Mostrando 49-60 de 578 artigos, teses e dissertações.
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49. TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review
Abstract During the course of evolution, multicellular organisms have been orchestrated with an efficient and versatile immune system to counteract diverse group of pathogenic organisms. Pathogen recognition is considered as the most critical step behind eliciting adequate immune response during an infection. Hitherto Toll-like receptors (TLRs), especially t
Braz J Infect Dis. Publicado em: 2016-04
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50. El cuerpo de la vejez desde una perspectiva de género. Aproximaciones desde La vejez de Simone de Beauvoir
Abstract: The essay situates the aging in the contemporary society, a stage in life imbued by multiples meanings granted by the bi-capitalism (NEGRI, 2014) which stigmatize it by using pejorative designations. Among the most commonly used designations we may find the ones that present the elderly as a "problem", or a "burden impossible to be carried" by the
Cad. CEDES. Publicado em: 2015-12
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51. Synthesis and Evaluation of Thiazolyl-1H-benzo[
d ]imidazole Inhibitors ofMycobacterium tuberculosis Inosine Monophosphate DehydrogenaseUsing an orthologue-based design approach, we synthesized and assayed a series of thiazolyl-1
H -benzo[d ]imidazole derivatives as inhibitors ofMycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mt IMPDH). From these experiments, a benzo[d ] imidazole compoundJ. Braz. Chem. Soc.. Publicado em: 2015-07
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52. The clinical effectiveness of pegylated interferon and ribavirin for the treatment of chronic hepatitis C in HIV-infected patients in Brazil: a multicentric study
Introduction: in Brazil, chronic hepatitis C in patients coinfected with the human immunodeficiency virus (HIV) is treated with pegylated interferon (Peg-IFN) and ribavirin (RBV). However, few studies have evaluated the effectiveness of this treatment in this particular population. The identification of the factors that predict sustained virological respon
Braz J Infect Dis. Publicado em: 2015-02
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53. Post stroke depression: clinics, etiopathogenesis and therapeutics
Background Stroke is a major cause of morbidity and mortality worldwide. Neuropsychiatric disorders are often associated with stroke and, among them, depression is the most prevalent. Post-stroke Depression (PSD) is related to disability, failure in returning to work, impairment in interpersonal functioning and mortality. Its etiopathogenesis is still uncer
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2015-01
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54. The association of HLA-DRB1 alleles and drug use with HIV infection in a Chinese Han Cohort
Objective: To investigate the relationship between the polymorphism of human leukocyte antigen (HLA)-DRB1 and the susceptibility and repellency of drug use combined with HIV infection in Chinese. Methods: A total of 213 unrelated healthy people, 41 HIV-infected drug users, 24 HIV-uninfected drug users, and 64 HIV-infected non-drug users were recruited. Th
Braz J Infect Dis. Publicado em: 2014-01
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55. Biomarkers in mood disorders research: developing new and improved therapeutics
Background Recently, surrogate neurobiological biomarkers that correlate with target engagement and therapeutic response have been developed and tested in early phase studies of mood disorders. Objective The identification of biomarkers could help develop personalized psychiatric treatments that may impact public health. Methods These biomarkers, which are
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2014
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56. The impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic review
Objective: Functional neuroimaging techniques represent fundamental tools in the context of translational research integrating neurobiology, psychopathology, neuropsychology, and therapeutics. In addition, cognitive-behavioral therapy (CBT) has proven its efficacy in the treatment of anxiety disorders and may be useful in phobias. The literature has shown t
Rev. Bras. Psiquiatr.. Publicado em: 2013-09
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57. Preparation of poly(urethane-urea) nanoparticles containing açaí oil by miniemulsion polymerization
Polyurethane nanoparticles (NPs) are promising candidates for the controlled and targeted delivery of therapeutics in a variety of biomedical applications. In this work, a report is made of NPs produced by miniemulsion polymerization with isophorone diisocyanate (IPDI) and castor oil, glycerol, and poly(ethylene glycol) (PEG) with molar masses 400 and 1000 a
Polímeros. Publicado em: 27/08/2013
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58. Herbal medicines: old and new concepts, truths and misunderstandings
Men have been using herbal medicines for thousands of years. The advantages of this type of therapeutics include good availability, local cultural aspects, individual preferences, the increasing demand for natural and organic products, and the already validated synergistic effects of herbal medicines. However, ethically, the scope and limits of these drugs n
Rev. bras. farmacogn.. Publicado em: 25/02/2013
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59. Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax
The PfCLAG9 has been extensively studied because their immunogenicity. Thereby, the gene product is important for therapeutics interventions and a potential vaccine candidate. Antibodies against synthetic peptides corresponding to selected sequences of the Plasmodium falciparum antigen PfCLAG9 were found in sera of falciparum malaria patients from Rondônia,
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-02
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60. Reações adversas durante condicionamento para transplante autólogo de células tronco hematopoéticas em vigência do uso de globulina antitimocitária / Adverse reactions during conditioning for autologous hematopoietic stem cell transplantation with the use of anti-thymocyte globulin
Multiple sclerosis (MS) is a progressive demyelinating autoimmune disease, immune- mediated by auto-reactive T lymphocytes, which provoke an immunological cascade, enhancing the local inflammation. In type 1 diabetes mellitus (DM1), self-reactive T lymphocytes exist that destroy ? cells in the pancreas, causing insulin production deficiency. The development
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/08/2012