Thalassemia Major
Mostrando 13-24 de 39 artigos, teses e dissertações.
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13. Avaliação dos parâmetros bioquímicos e hematológicos associados ao estudo molecular para caracterização da beta-talassemia heterozigótica / Evaluation of biochemical and hematological parameters associated with molecular study for characterization of the beta-thalassemia heterozygous
Talassemias são as mais comuns desordens monogenéticas em humanos; são caracterizadas pela presença de anemia microcíticas e hipocrômicas que resultam da redução ou ausência na síntese de uma ou mais cadeias globínicas. No Brasil a beta-talassemia tem importante significado clínico e sua ocorrência pode ser explicada como conseqüência da grand
Publicado em: 2008
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14. Clinical, biochemical and molecular aspects of the talassemic syndromes in the population of Pernambuco State / Aspectos clinicos, bioquimicos e moleculares das sindromes talassemicas em população do estado de Pernambuco
? Thalassemia is a frequent inherited disease of the Hb molecule found in the majority of populations and distributed worldwide. The prevalence of this syndrome in Brazil has been studied for a long time, but due to limitations in the methodology of some research, data on prevalence and clinical diversity are not fully complete. Furthermore, as a consequence
Publicado em: 2007
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15. Alterações tireoideanas em pacientes com beta-talassemia maior submetidos a hipertransfusão sanguinea
Among several clinical presentations of thalassemia syndromes, beta¬thalassemia major (Cooley s disease) is one of the great severity. The clinical features consist of chronic hemolytic anemia, from the early years of life, and severe hypoxia, requiring a regimen of chronic blood transfusions to survive. Treatment with chronic regular transfusions leads to
Publicado em: 1999
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16. STUDIES ON THALASSEMIA PART I. AN EXTRACORPUSCULAR DEFECT IN THALASSEMIA MAJOR PART II. THE EFFECTS OF SPLENECTOMY IN THALASSEMIA MAJOR WITH AN ASSOCIATED ACQUIRED HEMOLYTIC ANEMIA12
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17. Metabolic and endocrinologic complications in beta-thalassemia major: a multicenter study in Tehran
BioMed Central.
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18. An international survey of patients with thalassemia major and their views about sustaining life-long desferrioxamine use
BioMed Central.
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19. Pancreatic iron loading predicts cardiac iron loading in thalassemia major
Diabetes mellitus and cardiomyopathy are common in chronically transfused thalassemia major patients, occurring in the second and third decades of life. We postulated that pancreatic iron deposition would precede cardiac iron loading, representing an environment favorable for extrahepatic iron deposition. To test this hypothesis, we examined pancreatic and c
American Society of Hematology.
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20. Effects of α-Thalassemia on Pharmacokinetics of the Antimalarial Agent Artesunate
Thalassemia is common in Southeast Asia, where artemisinin derivatives are frequently used in the treatment of malaria. It has been previously reported that artemisinin derivatives can be concentrated by uninfected thalassemic erythrocytes in vitro but not by normal erythrocytes. As a follow-up to this report, we studied the antimalarial kinetics of intravas
American Society for Microbiology.
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21. Further evidence of a quantitative deficiency of chain-specific globin mRNA in the thalassemia syndromes.
Formamide gel electrophoresis separates the mRNA fraction from reticulocyte polyribosomes of adult humans into two major RNA species with migratory rates identical to those of the alpha- and beta-globin mRNAs of the rabbit. That these two RNAs of human origin are the globin mRNAs is further supported by the deficiency of the presumed beta mRNA in reticulocyt
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22. Preclinical transfusion-dependent humanized mouse model of β thalassemia major
A preclinical humanized mouse model of β thalassemia major or Cooley anemia (CA) was generated by targeted gene replacement of the mouse adult globin genes in embryonic stem cells. The mouse adult α and β globin genes were replaced with adult human α globin genes (α2α1) and a human fetal to adult hemoglobin (Hb)–switching cassette (γHPFHδβ0), resp
American Society of Hematology.
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23. Synergic effect of chronic hepatitis C infection and beta thalassemia major with marked hepatic iron overload on liver fibrosis: a retrospective cross-sectional study
BioMed Central.
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24. Estimates of the effect on hepatic iron of oral deferiprone compared with subcutaneous desferrioxamine for treatment of iron overload in thalassemia major: a systematic review
BioMed Central.