Target Vectors
Mostrando 1-12 de 432 artigos, teses e dissertações.
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1. Synthesis of new α-amino nitriles with insecticidal action on Aedes aegypti (Diptera: Culicidae)
Abstract Aedes aegypti is the principal vector of arboviral pathogens that may cause diseases as dengue fever, chikungunya and zika. The harmful environmental effects of commercial pesticides coalesced with the development of insecticide-resistant populations encourage the discovery and generation of new alternative products as a tool to reduce the incidence
Rev. Bras. entomol.. Publicado em: 2018-06
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2. Entomopathogenic fungi and their potential for the management of Aedes aegypti (Diptera: Culicidae) in the Americas
Classical biological control has been used extensively for the management of exotic weeds and agricultural pests, but never for alien insect vectors of medical importance. This simple but elegant control strategy involves the introduction of coevolved natural enemies from the centre of origin of the target alien species. Aedes aegypti - the primary vector of
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-03
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3. Interruption of vector transmission by native vectors and “the art of the possible”
In a recent article in the Reader’s Opinion, advantages and disadvantages of the certification processes of interrupted Chagas disease transmission (American trypanosomiasis) by native vector were discussed. Such concept, accepted by those authors for the case of endemic situations with introduced vectors, has been built on a long and laborious process by
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-02
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4. Adenovirus-mediated siRNA targeting TNF-α and overexpression of bone morphogenetic protein-2 promotes early osteoblast differentiation on a cell model of Ti particle-induced inflammatory response in vitro
Wear particles are phagocytosed by macrophages and other inflammatory cells, resulting in cellular activation and release of proinflammatory factors, which cause periprosthetic osteolysis and subsequent aseptic loosening, the most common causes of total joint arthroplasty failure. During this pathological process, tumor necrosis factor-alpha (TNF-α) plays a
Braz J Med Biol Res. Publicado em: 2013-10
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5. Avançada análise do uso de novos vetores-alvo em MLPs de alta performance / Advanced analysis of using new target vectors on high performance MLPs
O presente trabalho propõe a análise avançada para a melhoria de desempenho de MLP através do uso de novos vetores-alvo. Primeiramente, por meio de um estudo matemático, avalia-se a influência dos VBOs sobre o treinamento das MLPs quando são utilizados como vetores-alvo. Os VBOs possuem a maior distância euclidiana possível entre si, o que leva a su
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/09/2012
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6. Recombinant vaccines and the development of new vaccine strategies
Vaccines were initially developed on an empirical basis, relying mostly on attenuation or inactivation of pathogens. Advances in immunology, molecular biology, biochemistry, genomics, and proteomics have added new perspectives to the vaccinology field. The use of recombinant proteins allows the targeting of immune responses focused against few protective ant
Braz J Med Biol Res. Publicado em: 2012-12
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7. BC047440 antisense eukaryotic expression vectors inhibited HepG2 cell proliferation and suppressed xenograft tumorigenicity
The biological functions of the BC047440 gene highly expressed by hepatocellular carcinoma (HCC) are unknown. The objective of this study was to reconstruct antisense eukaryotic expression vectors of the gene for inhibiting HepG2 cell proliferation and suppressing their xenograft tumorigenicity. The full-length BC047440 cDNA was cloned from human primary HCC
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-02
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8. Papel de TGFβ-1 na regulação da expressão de MMPs seus inibidores (TIMPs e Reck) em modelo de carcinoma mamário humano: análise funcional de RECK e sua correlação com dados clínico-patológicos / Role of TGFβ-1 as a common regulator of MMPs and their inhibitors (TIMPs e RECK) in human breast cancer cell model: functional analysis of RECK and its correlation with clinical-pathological
The metastatic disease is the main mortality cause of breast cancer patients. The metastatic process involves a complex cascade of events, including the organized breakdown of the extracellular matrix (ECM) compounds. The degradation of ECM is tightly regulated by the balance between the activities of matrix metalloproteinases (MMPs) and their inhibitors, th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/10/2011
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9. Análise de uma heme oxigenase funcional em Trypanosoma cruzi / Heme oxygenase analysis in Trypanosoma cruzi
Trypanosoma cruzi, the ethiologic agent of Chagas disease, is transmitted through triatomine vectors during their blood-meal on vertebrate host. These hematophagous insects ingest blood about 6 to 12 times its original weight, reaching in a single meal about 10 mM heme bound to hemoglobin. Heme (iron protoporphyrin IX) is an important molecule in metabolism
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/02/2011
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10. The state of the art of adeno-associated virus-based vectors in gene therapy
The adeno-associated virus (AAV) has rapidly gained popularity in gene therapy since the establishment of the first AAV2 infectious clone, in 1982, due to some of their distinguishing characteristics such as lack of pathogenicity, wide range of infectivity, and ability to establish longterm transgene expression. Notably over the past decade, this virus has a
Publicado em: 2010
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11. Is an HIV vaccine possible?
The road to the discovery of a vaccine for HIV has been arduous and will continue to be difficult over the ensuing twenty years. Most vaccines are developed by inducing neutralizing antibodies against the target pathogen or by using attenuated strains of the particular pathogen to engender a variety of protective immune responses. Unfortunately, simple metho
Brazilian Journal of Infectious Diseases. Publicado em: 2009-08
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12. Construção de ferramentas para estudo da possível interação entre interferon-beta e p53. / Construction of tools for study of the possible interaction between interferon-beta and P53.
Formation of tumors it must to combinations of factors. The p53 pathway has an essential role in proliferation control and apoptosis. The interferon-beta (IFNb) is important in modulation of the immunologic response, in the antitumoral effect and in the apoptotic impact in tumor cells. According to literature, IFNb activate the p53 transcription and componen
Publicado em: 2009