Target Organs
Mostrando 25-36 de 302 artigos, teses e dissertações.
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25. Alterações morfológicas de Tilápias do Nilo (Oreochromis niloticus) (Linnaeus, 1758) expostas às águas da represa Billings. / Morphologic alterations of Nile Tilapia (Oreochromis niloticus) (Linnaeus, 1758) exposed to waters of Billings dam.
The Billings dam shows eutrophic waters due to the large amount of sewage from urban occupation neaby, and consequently, the fish can be a public health problem. The gills and liver become target organs for the action of pollutants in the aquatic environment and may present several levels of biological organization. These biological responses to stress cause
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/07/2011
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26. MILTEFOSINA EXERCE SUA AÇÃO LEISHMANICIDA ATRAVÉS DO RECEPTOR DE PAF
Visceral leishmaniasis,that can be caused by Leishmania donovani, L. infantum and L. chagasi, is considered by the World Health Organization (WHO) one of six major public health problems worldwide and is fatal if untreated. Miltefosine (hexadecylphosphocolina), which was first used as treatment in patients with cancer, has been used as an effective oral drug
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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27. Biodisponibilidade de ácidos fenólicos
The daily intake of phenolic compounds does not necessarily reflect the dose at which they reach the physiological targets in the organisms. The biological activity of phenolic compounds metabolites found in blood, organs and target tissues, as a result of digestive and hepatic activity, may differ from those of the native forms of the substances. This revie
Química Nova. Publicado em: 2011
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28. Análise da via de regulação gênica do miRNA156/SPL na brotação lateral e caracterização molecular do processo de emergência da gema axilar de cana de açucar / Analysis of the role(s) of the miRNA156/SPL pathway on branching/tillering and molecular characterization of sugarcane lateral bud outgrowth
Sugarcane is an economically important biofuel crop that recently has become a target for improvement of sustainable biomaterial production due to its high biomass productivity and built-in containment features. Therefore, studies aiming to improve the production of biomass per area are among the most important issues in sugarcane production. Plant biomass i
Publicado em: 2011
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29. Agonistas PPAR (Rosiglitazona, Bezafibrato e Fenofibrato) e alterações bioquímicas e estruturais em órgãos-alvo de camundongos C57BL/6 alimentados com dieta hiperlipídica rica em sacarose / PPAR agonists (Rosiglitazone, Bezafibrate and Fenofibrate) and biochemical and structural changes in target organs of C57BL/6 mice fed a high-fat high-sucrose diet
This work aimed to evaluate the effect of peroxisome proliferator-activated receptor (PPAR) agonists (rosiglitazone, fenofibrate and bezafibrate) on lipid and glucose metabolism, body mass, and adipose and pancreatic tissue morphology in a model of diet-induced type 2 diabetes and overweight in mice. Two-month-old male C57BL/6 mice were fed a standard chow (
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/06/2010
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30. Desenvolvimento e farmacocinética de antimônio encapsulado em lipossomas de fosfatidilserina utilizando radioisótopos em leishmaniose experimental / Development and pharmacokinetic of antimony encapsulated in liposomes of phosphatidylserine using radioisotopes in experimental leishmaniasis
Leishmaniases are a complex of parasitic diseases caused by intramacrophage protozoa of the genus Leishmania, and is fatal if left untreated. Pentavalent antimonials, though toxic and their mechanism of action being unclear, remain the first-line drugs for treatment. Effective therapy could be achieved by delivering antileishmanial drugs to these sites of in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/03/2010
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31. A clinical gamma camera-based pinhole collimated system for high resolution small animal SPECT imaging
The main objective of the present study was to upgrade a clinical gamma camera to obtain high resolution tomographic images of small animal organs. The system is based on a clinical gamma camera to which we have adapted a special-purpose pinhole collimator and a device for positioning and rotating the target based on a computer-controlled step motor. We deve
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-12
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32. Angiotensin converting enzyme inhibition on the aorta, liver, kidney and pancreas in conditions of hyperglycemia and hypercholesterolemia experimentally induced / Ação da inibição da enzima conversora da angiotensina em aorta, fígado, rim e pâncreas em condições de hipercolesterolemia e hiperglicemia induzidas experimentalmente
Diabetes Mellitus is a major risk factor for vascular disease and the imbalance of the renin-angiotensin system exerts deleterious effects on various organs, further the use of ACE inhibitor or AT1 receptor blockers may exerts a beneficial effect. Objective: We performed a retrospective study where the effect of an ACE inhibitor, quinapril, on changes in tar
Publicado em: 2010
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33. Papel do IFN- e da iNOS na patogênese do dengue experimental
Dengue is currently the most important mosquito-borne disease that affects humans and constitutes a serious world health problem. The lack of specific treatment and vaccine, and the incipient knowledge about pathogenesis contribute to the growing numbers of cases. A major limitation in the field of DENV research is the lack of animal models that mimic the hu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/06/2009
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34. Structural and functional aspects in Möbius syndrome children: a speech therapy view / Aspectos estruturais e funcionais em crianças portadoras da seqüência de Möbius: uma visão fonoaudiológica
The aim of this study was to evaluate MS oral miofunctional system and stomatognathic functions in order to define MS phonoaudiological structural phenotype and correlate any changes with the affected anatomical structures, aiming at preparing a standard of care program targeted to MS. Thirty-one male and female patients aged 4 to 16 years old were examined
Publicado em: 2009
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35. Cromatografia negativa em Sepharose-TREN como tecnica de purificação de proteinas adicionadas artificialmente a extrato de soja / Negative chromatography on Sepharose-TREN as a technique of proteins purification artificially added to soybean extract
In recent years, plants have been studied as bioreactors for the production of recombinant proteins with industrial and pharmaceutical interest. When compared to other expression systems, plants have several advantages, such as the possibility of posttranlationals modification, low production cost, low risk of contamination by human pathogens, and the accumu
Publicado em: 2009
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36. Análise de células CD4+CD25+FoxP3+ no timo de camundongos infectados pelo Trypanosoma cruzi. / Analysis of cells CD4 CD25 FoxP3 in the thymus of mice infected for the Trypanosoma cruzi.
Natural regulatory T cells arise in the thymus during the normal process of differentiation and participate in the control of auto and alloimmune responses. Specifically in parasite infections, these cells may have antagonist roles, in favor of the microorganism or the host. Previous studies from our Laboratory revealed that acute Trypanosoma cruzi (T. cruzi
Publicado em: 2008