Systemic Scleroderma
Mostrando 13-24 de 108 artigos, teses e dissertações.
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13. Estudo da interação endotélio-matriz extracelular no remodelamento da pele observado no modelo experimental de esclerodermia e na enfermidade espontânea humana / Study of endothelium-extracellular matrix interaction in skin remodeling observed in an experimental model of scleroderma and spontaneous human disease
Introdução: A imunização de coelhos saudáveis com colágeno do tipo V (COLV) reproduz as principais manifestações da esclerose sistêmica (ES), incluindo fibrose, vasculopatia e produção de autoanticorpos específicos da doença. Estudos preliminares mostraram que, tanto na derme de animais imunizados com COLV (COLV-IM), como na derme de pacientes c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/10/2012
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14. Avaliação da vasculatura pulmonar na esclerose sistêmica / Evaluation of pulmonary vasculature in systemic sclerosis
A lesão pulmonar é a principal causa de morte da Esclerose Sistêmica (ES), e as alterações principais são: o acometimento intersticial e o vascular. No presente estudo analisamos através do microscópio confocal a laser 40 artérias pulmonares de pequeno e médio calibre de pacientes com ES e 16 controles. Medimos a área do lúmen, a área total do v
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/09/2011
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15. Histomorphometric analysis of cutaneous remodeling in the early stage of the scleroderma model
INTRODUCTION/OBJECTIVES: Systemic sclerosis, or scleroderma, is a rheumatic disease characterized by autoimmunity, vasculopathy, and fibrosis of the skin and several internal organs. In the present study, our aim was to assess the skin alterations in animals with scleroderma during the first stages of disease induction. METHODS: To induce scleroderma, female
Clinics. Publicado em: 2009-06
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16. Collagen V- induced nasal tolerance in scleroderma experimental model / Indução de tolerância nasal com colágeno tipo V em modelo experimental de esclerodermia
Objective: Our aim was to verify the skin remodeling and antibody production in experimental model of scleroderma in rabbits, after induction of tolerance by daily nasal administration of human type V collagen (Col V). Methods: Female New Zealand rabbits (N=12) were immunized with 1mg/ml of Col V in complete Freunds adjuvant, followed by more two boosters in
Publicado em: 2007
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17. Scleroderma-like remodeling induced by type V collagen / Remodelamento da pele semelhante à esclerodermia induzido pelo colágeno tipo V
Recentemente, descobrimos que coelhos, Nova Zelândia, imunizados com colágeno tipo V humano mais adjuvante de Freund apresentavam fibrose e vasculite de órgãos normalmente afetados na esclerose sistêmica. Deste modo, nós estudamos o processo de fibrilogênese para identificar possíveis fatores envolvidos na alteração do remodelamento observado neste
Publicado em: 2007
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18. Centrilobular fibrosis (CLF): a distinct histological pattern in systemic sclerosis with interstitial lung disease (ILD) / Fibrose centrilobular (FCL): um padrão histológico pulmonar distinto em pacientes com esclerose sistêmica e doença intersticial pulmonar
Objectives: CLF is a new histological pattern of idiopathic ILD associated to esophageal reflux. We have investigated its presence in SSc with lung involvement. Methods: 28 SSc patients were submitted to open lung biopsy. The specimens were classified according to the new consensus classification of idiopathic interstitial pneumonia and to the diagnostic cri
Publicado em: 2007
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19. Ergospirometric assessment in scleroderma patients / "Avaliação ergoespirométrica em pacientes com esclerodermia"
INTRODUÇÃO: Já é sabido que a capacidade funcional é reduzida nos pacientes com doenças reumatológicas. Entretanto, há poucos estudos que avaliam a capacidade funcional em pacientes com esclerodermia, uma doença rara com manifestações vasculares, músculo-esqueléticas, e viscerais. OBJETIVO: Avaliar a capacidade funcional de pacientes com esclero
Publicado em: 2006
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20. Antiubiquitin antibody in localised and systemic scleroderma.
OBJECTIVE: To determine the presence of antiubiquitin antibody (AUbA) in localised scleroderma and systemic sclerosis, as it is frequently found in the sera of patients with systemic lupus erythematosus (SLE) and has also been shown to have a close relationship with antihistone antibodies that have an important role in scleroderma. METHODS: Serum samples fro
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21. Systemic and cell type-specific gene expression patterns in scleroderma skin
We used DNA microarrays representing >12,000 human genes to characterize gene expression patterns in skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma. We found consistent differences in the patterns of gene expression between skin biopsies from individuals with scleroderma and those from normal, unaffected indivi
National Academy of Sciences.
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22. Rapidly progressive scleroderma associated with carcinoma of the oesophagus.
A patient with scleroderma of recent onset was found to have a carcinoma of the oesophagus. The rapid progression of the scleroderma suggested the possibility that it represented a systemic manifestation of malignancy.
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23. Cutaneous antigen-stimulating lymphokine production by lymphocytes of patients with progressive systemic sclerosis (scleroderma).
Cell-mediated immunity to skin extracts was studied by the macrophage migration inhibition test, lymphocyte transformation, and direct cytotoxicity to skin fibroblasts, in normal individuals and patients with progressive systemic sclerosis. The latter included 18 individuals with diffuse scleroderma and 12 with the CREST syndrome, a variant form of systemic
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24. Remission of scleroderma during chemotherapy for lymphoma.
Temporary remission of scleroderma during the successful treatment of an associated malignant lymphoma by chemotherapy is reported in a patient with systemic sclerosis and mixed connective tissue disease. There is a well established relation between malignant disease and polymyositis/dermatomyositis but no overall association with systemic sclerosis or mixed