Synapse
Mostrando 1-12 de 549 artigos, teses e dissertações.
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1. New frontiers in the study of memory mechanisms
We review recent work on three major lines of memory research: a) the possible role of the protein kinase M-zeta (PKMzeta) in memory persistence; b) the processes of “synaptic tagging and capture” in memory formation; c) the modulation of extinction learning, widely used in the psychotherapy of fear memories under the name of “exposure therapy”. PKMz
Rev. Bras. Psiquiatr.. Publicado em: 2013-06
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2. Synaptic vesicle cycling is not impaired in a glutamatergic and a cholinergic synapse that exhibit deficits in acidification and filling
O objetivo do presente trabalho foi investigar o tráfego de vesículas sinápticas quando estas apresentam alterações no armazenamento de neurotransmissores e acidificação em duas distintas sinapses: a junção neuromuscular colinérgica de rãs versus o terminal nervoso glutamatérgico do tipo ribbon em céulas bipolares da retina. Essas sinapses exibe
Brazilian Journal of Pharmaceutical Sciences. Publicado em: 2012-03
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3. Investigação do efeito neuroprotetor da atorvastatina em um modelo in vitro de toxicidade induzida pelo peptídeo ¿-amiloide
Alzheimer¿s disease is an age-related neurodegenerative disorder characterized by progressive memory loss, inability to perform the activities of daily living and personality changes. AD is characterized histopathologically by the presence of senile plaques, neurofibrillary tangles, synapse loss and neuronal death. Moreover, it is now recognized that neuroi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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4. Tratamento com taurina e interferon beta influencia a expressão do complexo de histocompatibilidade principal de classe I (MHC I) e a formação de sinapses em células PC12 / Interferon beta and taurine treatment induce major histocompatibility complex class I (MHC I) upregulation and synapse plasticity in PC12 cells
It has been demonstrated that MHC I up regulation by exogenous treatment with interferon beta (IFN beta) influences the glial reaction and the synaptic elimination process. Also, the amino acid taurine has been shown to positively influence neuronal survival and plasticity. Nevertheless, the establishment of an in vitro model for studying the synaptic format
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2011
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5. The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is r
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-04
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6. Synaptic vesicle pool size, release probability and synaptic depression are sensitive to Ca2+ buffering capacity in the developing rat calyx of Held
The calyx of Held, a specialized synaptic terminal in the medial nucleus of the trapezoid body, undergoes a series of changes during postnatal development that prepares this synapse for reliable high frequency firing. These changes reduce short-term synaptic depression during tetanic stimulation and thereby prevent action potential failures during a stimulus
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-01
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7. Integrated Cardio-Respiratory Mechanisms within the brainstem: Involvement of the Caudal Pressor Area, the Nucleus of the Solitary Tract and the Retrotrapezopid Nucleus. / Mecanismos Cardio-Respiratórios Integrados na Região Bulbar: Participação da Área Pressora Caudal, dos Núcleos do Trato Solitário e do Núcleo Retrotrapezóide.
Cardiovascular responses are integrated at different levels of the central nervous system (CNS). In the brainstem, there are different areas related to the cardiovascular control. It is well known that in the ventrolateral medulla there are, at least, three important regions involved with cardiovascular control: the rostral ventrolateral medulla (RVLM), the
Publicado em: 2009
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8. Localização no tempo e no espaço em redes de sensores sem fio
Redes de Sensores Sem Fio (RSSF) são redes basicamente guiadas por eventos. Um evento pode ser definido como sendo composto por um critério causal e um critério espaço-temporal. No primeiro caso, o tipo do evento é identificado, enquanto que no segundo, a localização no tempo e no espaço em que o evento ocorreu é especificada. Um nó sensor é capaz
Publicado em: 2008
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9. Sistema de simulação de circuitos neuronais da medula espinhal desenvolvido em arquitetura web. / Simulation system of spinal cord neuronal circuitry developed in a web-based architecture
Este trabalho descreve o desenvolvimento de um sistema de simulação de circuitos neuronais, com interface de utilização amigável e arquitetura baseada em web. O sistema é direcionado ao estudo de redes de neurônios da medula espinhal, responsáveis pelo controle motor, sujeitas à ativação por vias superiores e periféricas ou por estímulos elétri
Publicado em: 2007
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10. Comportamento complexo em centros geradores de padrões / Complex behavior in central pattern generators
Realizamos simulações computacionais de modelos da atividade elétrica de centros geradores de padrões para investigar o fato experimental de organismos vivos utilizarem neurônios caóticos para produzir padrões periódicos. Centros geradores de padrões biológicos produzem atividades motoras periódicas que devem ser robustas a pequenas flutuações d
Publicado em: 2005
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11. Differentiation of autonomic reflex control begins with cellular mechanisms at the first synapse within the nucleus tractus solitarius
Visceral afferents send information via cranial nerves to the nucleus tractus solitarius (NTS). The NTS is the initial step of information processing that culminates in homeostatic reflex responses. Recent evidence suggests that strong afferent synaptic responses in the NTS are most often modulated by depression and this forms a basic principle of central in
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-04
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12. Expressão de ligantes da lectina KM+ durante a ontogenese cerebelar do rato
Lectins are non-immune, non-enzymatic proteins that bind carbohydrates. They can aglutinate cells and precipitate glyconconjugates. Since they are abundant in plants and can be easily purified, they are commonly used as probes to detect, isolate and characterize soluble or membrane-bound glycoproteins. They have been employed to detect glycoproteins involved
Publicado em: 2001