Streptozocin
Mostrando 1-12 de 27 artigos, teses e dissertações.
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1. Dexmedetomidine Leads to the Mitigation of Myocardial Ischemia/Reperfusion-Induced Acute Lung Injury in Diabetic Rats Via Modulation of Hypoxia-Inducible Factor-1α
ABSTRACT Introduction: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1α (HIF-1α). Methods: Initially, healthy male Sprague Dawley rats were treated with streptozocin to induce d
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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2. Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats
Abstract: Type 1 diabetes (T1D) is the result of the selective destruction of the pancreatic β-cells by T cells of the immune system. Although spleen is a secondary lymphoid organ, it is also involved in the T1D pathogenesis. However, the alterations in a variety of cellular processes of this disease need to be further understood. We aimed to analyze the be
An. Acad. Bras. Ciênc.. Publicado em: 09/09/2019
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3. Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
Olanzapine and risperidone are widely prescribed atypical antipsychotics used in the treatment of schizophrenia and various other psychiatric disorders. Both of these drugs have been extensively reported to cause Type 2 diabetes mellitus and pancreatitis, however, the mechanism of olanzapine and risperidone-induced toxicity has not been so far unveiled. We,
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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4. Efeito da farinha da batata yacon (Smallanthus Sonchifolius) sobre o perfil glicêmico de ratos / Effect of yacon potato flour (Smallanthus sonchifolius) on blood glucose levels of rats
The morbidity and mortality profile of the Brazilian population has changed recently in light of the increasing prevalence of chronic noncommunicable diseases. Of particular importance among these diseases is diabetes, a multiple-etiology disease characterized by insulin deficiency or decreased insulin production, or both. A major treatment goal is glycemic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/04/2011
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5. Effect of yacon potato flour (Smallanthus sonchifolius) on blood glucose levels of rats / Efeito da farinha da batata yacon (Smallanthus Sonchifolius) sobre o perfil glicêmico de ratos
Nos últimos tempos observaram-se mudanças no perfil de morbimortalidade da população brasileira, em função do aumento de prevalência das doenças crônicas não transmissíveis. Pode-se destacar entre elas o diabetes que é uma doença de etiologia múltipla que se caracteriza pela deficiência de produção de insulina, diminuição dessa produção
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/04/2011
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6. Influência do Diabetes Mellitus sobre as alterações ósseas alveolares ocorridas no trauma oclusal : estudo histométrico em ratos / The influence of Diabetes Mellitus on alveolar bone changes occuring in occlusal trauma : a histometric study in rats
O objetivo do presente estudo foi avaliar a influência do diabetes mellitus (DM) sobre a reabsorção óssea alveolar ocorrida no trauma oclusal (TO) na presença e ausência da periodontite experimental (PE) em ratos. Para tanto, 32 ratos Wistar (Rattus Novergicus) adultos foram aleatoriamente distribuídos em 4 grupos: Grupo 1 (n=08): DM+TO+PE; Grupo 2 (n
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/07/2010
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7. Avaliação dos estoques de glicogênio placentário em ratas com diabete moderado
OBJETIVO: Avaliar os estoques de glicogênio placentário e o desenvolvimento fetal na prenhez de ratas com diabete moderado induzido no período neonatal e relacionar com glicemia e níveis de insulina. MÉTODOS: No dia de nascimento, foram distribuídas aleatoriamente 147 ratas em dois grupos experimentais: 1) Grupo Não-diabético (Controle, n=45) - receb
Acta Cirurgica Brasileira. Publicado em: 2010-04
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8. Efeitos da hiperglicemia e do envelhecimento na cicatrização de anastomoses colônicas, em ratos
INTRODUÇÃO: Apesar dos significantes avanços no conhecimento do processo cicatricial há um restrito número de estudos demonstrando as relações deste reparo com o envelhecimento e com níveis elevados de glicemia. OBJETIVO: Avaliar os efeitos do envelhecimento e da hiperglicemia na cicatrização de anastomoses colônicas. MÉTODOS: Utilizaram-se 138 r
Acta Cirurgica Brasileira. Publicado em: 2009-04
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9. A microcirculação da bolsa da bochecha do hamster sob a influência do diabetes mellitus experimental induzido por estreptozotocina: aspectos morfofuncionais / Microcirculation of hamster cheek pouch under the influence of exerimental diabetes mellitus induced by streptozocin morpho-functional aspects
Diabetes Mellitus is a chronic metabolic disease with multiple etiologic factors (genetic, viral and immunological) that results in absolute or relative insulin deficiency, causing persistent elevated blood glucose levels. Nowadays, Diabetes Mellitus is considered as an important health concern due to its increasing prevalence and high morbimortality. Its cl
Publicado em: 2009
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10. Islet transplantation under the kidney capsule fully corrects the impaired skeletal muscle glucose transport system of streptozocin diabetic rats.
Chronic insulin therapy improves but does not restore impaired insulin-mediated muscle glucose uptake in human diabetes or muscle glucose uptake, transport, and transporter translocation in streptozocin diabetic rats. To determine whether this inability is due to inadequate insulin replacement, we studied fasted streptozocin-induced diabetic Lewis rats eithe
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11. Intestinal adaptation to diabetes. Altered Na-dependent nutrient absorption in streptozocin-treated chronically diabetic rats.
To examine the pattern and mechanisms of enhanced intestinal nutrient absorption in diabetes, we measured intestinal transport of 3-O-methylglucose (3OMG), l-alanine (ALA), and SO4 in male Lewis rats made diabetic with streptozocin. Diabetes enhanced 3OMG absorption fivefold in ileum and threefold in jejunum; ALA absorption increased twofold in ileum but not
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12. Mechanisms and time course of impaired skeletal muscle glucose transport activity in streptozocin diabetic rats.
Skeletal muscle glucose transport is altered in diabetes in humans, as well as in rats. To investigate the mechanisms of this abnormality, we measured glucose transport Vmax, the total transporter number, their average intrinsic activity, GLUT4 and GLUT1 contents in skeletal muscle plasma membrane vesicles from basal or insulin-stimulated streptozocin diabet