Steroidogenic Factor 1
Mostrando 1-12 de 49 artigos, teses e dissertações.
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1. New evidences on the regulation of SF-1 expression by POD1/TCF21 in adrenocortical tumor cells
OBJECTIVES: Transcription Factor 21 represses steroidogenic factor 1, a nuclear receptor required for gonadal development, sex determination and the regulation of adrenogonadal steroidogenesis. The aim of this study was to investigate whether silencing or overexpression of the gene Transcription Factor 21 could modulate the gene and protein expression of st
Clinics. Publicado em: 2017-06
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2. Clinical, pathological and morphometric study of ten male disgenetic pseudohermaphroditism (DSD 46,XY) / Estudo investigativo clínico, laboratorial, patológico, morfométrico, molecular de 10 pacientes com pseudohermafroditismo masculino disgenético (ADS 46, XY)
O Pseudohermafroditismo masculino disgenético (Anomalia da diferenciação sexual 46,XY ADS 46,XY) é definido como ambigüidade genital num paciente com testículos e/ou cariótipo 46,XY com uma das seguintes características: alteração histológica testicular, ausência ou hipoplasia das células de Leydig em tecido previamente estimulado com gonadotrof
Publicado em: 2010
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3. Expression of IGF-II, IGF-IR, SF-1 and DAX-1 genes in pediatric and adult adrenocortical tumors / Expressão dos genes IGF-II, IGF-IR, SF-1 e DAX-1 em tumores adrenocorticais de crianças e adultos
Introduction: The molecular pathogenesis of adrenocortical tumors is heterogeneous and incompletely understood. Insulin-like growth factor II (IGF-II) overexpression has been demonstrated in adult adrenocortical carcinomas. IGF-II exerts its mitogenic effects through interaction with IGF-I receptor (IGF-IR). In addition, steroidogenic factor 1 gene (SF-1) an
Publicado em: 2008
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4. Gene expression diferentialy in follicular cells in swine / Expressão diferencial de genes em células foliculares de suínos
Among the productive traits, the number of the piglets is essential for success in swine production. The ovulation rate is one of the key factors that determine the litter size in pigs and the study of gene expression in the ovary follicles, more precisely in the follicular cells, might cause a big advance in the comprehension of this characteristic. Thus, t
Publicado em: 2007
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5. Análise da expressão diferencial de genes do folículo ovariano de fêmeas pré-púberes e púberes Bos primigenius indicus (Nelore) por meio da Análise Serial de Expressão Gênica (SAGE) / Analysis of differential gene expression of ovarian follicle from prepubertal and pubertal Bos primigenius indicus (Nelore) females by Serial Analysis of Gene Expression (SAGE)
Puberty is the stage where any mammal, male or female, becomes able to produce viable gametes and manifest complete sexual behavior. These are results from the gradative adjustment between the increase in gonadotrophic activity and the ability of gonads in undergoing simultaneously both steroidogenesis and gametogenesis. One of the major factors interferring
Publicado em: 2005
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6. Inhibition of Adrenocortical Carcinoma Cell Proliferation by Steroidogenic Factor-1 Inverse Agonists
Context: Transcription factor steroidogenic factor-1 (SF-1) plays a pivotal role in the control of adrenocortical cell steroidogenesis and proliferation. SF-1 amplification and overexpression are found in most cases of childhood adrenocortical tumors (ACTs).
The Endocrine Society.
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7. Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/β-catenin synergy
Genetic studies in mice suggest that Wnt4 signaling antagonizes expression of male hormones and effectively blocks male development in the female embryo. We recently identified an XY intersex patient carrying a chromosomal duplication of the WNT4 locus and proposed that this patient's feminization arises from an increased dosage of WNT4. To test this hypothe
National Academy of Sciences.
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8. Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage.
The orphan nuclear receptor steroidogenic factor 1 (SF-1) is expressed in the adrenal gland and gonads and is an important regulator of the expression of cytochrome P-450 steroidogenic enzymes in cultured cells. Targeted disruption of the SF-1 gene in mice shows that it is a critical participant in the genetic program that promotes the development of urogeni
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9. Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols
Steroidogenic factor 1 (SF-1), an orphan member of the intracellular receptor superfamily, plays an essential role in the development and function of multiple endocrine organs. It is expressed in all steroidogenic tissues where it regulates the P450 steroidogenic genes to generate physiologically active steroids. Although many of the functions of SF-1 in viv
The National Academy of Sciences of the USA.
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10. Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response
Adrenal steroids are essential for homeostasis and survival during severe physiological stress. Analysis of a patient heterozygous for the steroidogenic factor-1 (SF-1) gene suggested that reduced expression of this nuclear receptor leads to adrenal failure. We therefore examined SF-1 heterozygous (+/−) mice as a potential model for delineating mechan
The National Academy of Sciences.
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11. SF-1 a key player in the development and differentiation of steroidogenic tissues
Since its discovery in the early 1990s, the orphan nuclear receptor SF-1 has been attributed a central role in the development and differentiation of steroidogenic tissues. SF-1 controls the expression of all the steroidogenic enzymes and cholesterol transporters required for steroidogenesis as well as the expression of steroidogenesis-stimulating hormones a
BioMed Central.
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12. The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.
We examined in detail the DNA interaction of the nuclear receptors NGFI-B and steroidogenic factor 1 (SF-1) by using a series of gain-of-function domain swaps. NGFI-B bound with high affinity as a monomer to a nearly linear DNA molecule. The prototypic zinc modules interacted with a half-site of the estrogen receptor class, and a distinct protein motif carbo