Staurosporine
Mostrando 1-12 de 272 artigos, teses e dissertações.
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1. PHYTOCHEMICAL ANALYSIS OF HYDROETHANOLIC EXTRACTS FROM POWDERED ROOTS OF Panax ginseng C. A. Meyer AND Heteropterys tomentosa A. Juss AND EVALUATION OF THEIR EFFECTS ON ASTROCYTE CELL DEATH
The medicinal plants Panax ginseng C. A. Meyer (Araliaceae) and Heteropterys tomentosa A. Juss (Malpighiaceae) are widely and separately used by the Brazilian population as phytotherapeutics for the same medicinal purposes as tonics and to improve cognition. A chemical analysis was carried out on hydroethanolic extracts of powdered roots from P. ginseng and
Quím. Nova. Publicado em: 2016-06
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2. Pyrimidine alkaloids from Eudistoma vannamei
Abstract Methanolic extracts of the Brazilian endemic ascidian Eudistoma vannamei have been extensively studied for their cytotoxic activity against several human cancer cell lines. Previous work reported the occurrence of purine derivatives and staurosporine alkaloids as the major nitrogen-containing compounds. In this study, we report the occurrence of thr
Rev. bras. farmacogn.. Publicado em: 2015-12
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3. STAUROSPORINE AND ITS EVOLVING ROLE IN INHIBITION OF GROWTH IN MALIGNANT TUMORS
Rev. Inst. Med. trop. S. Paulo. Publicado em: 2013-04
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4. Apoptotic-like activity of staurosporine in axenic cultures of Trypanosoma evansi
Trypanosoma evansi is a blood protozoan parasite of the genus Trypanosoma which is responsible for surra (Trypanosomosis) in domestic and wild animals. This study addressed apoptotic-like features in Trypanosoma evansi in vitro. The mechanism of parasite death was investigated using staurosporine as an inducing agent. We evaluated its effects through several
Revista do Instituto de Medicina Tropical de São Paulo. Publicado em: 2012-04
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5. Systematic UPLC-ESI-MS/MS study on the occurrence of staurosporine and derivatives in associated marine microorganisms from Eudistoma vannamei
O estudo fitoquímico do invertebrado marinho Eudistoma vannamei levou ao isolamento de derivados do alcalóide estaurosporina, que apresentaram uma potente atividade citotóxica contra linhagens de células humanas de câncer. A ocorrência destes alcalóides pode ser correlacionada a presença de microorganismos associados ao animal, como por exemplo bact�
J. Braz. Chem. Soc.. Publicado em: 2012-02
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6. Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults
Wnt proteins are involved in tissue development and their signaling pathways play an important role during embryogenesis. Wnt signaling can promote cell survival, which is beneficial for neurons, but could also lead to tumor development in different tissues. The present study investigated the effects of a Wnt protein on the susceptibility of a neural tumor c
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-01
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7. Effect of Bothrops alternatus snake venom on macrophage phagocytosis and superoxide production: participation of protein kinase C
Envenomations caused by different species of Bothrops snakes result in severe local tissue damage, hemorrhage, pain, myonecrosis, and inflammation with a significant leukocyte accumulation at the bite site. However, the activation state of leukocytes is still unclear. According to clinical cases and experimental work, the local effects observed in envenenoma
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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8. Efeitos da administração intraestriatal aguda de ácido quinolítico sobre o citoesqueleto de células neurais de ratos
In the present study we investigated the effect of in vivo intrastriatal injection of quinolinic acid (QA) on rat cytoskeleton proteins in astrocytes and neurons of young rats at early stages (30 min) after infusion. Intrastriatal QA injection is an excitotoxic model of Huntington´s Disease (HD). Results showed that QA (150¿mol/0.5¿L) significantly increa
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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9. Estaurosporinas de Eudistoma vannamei: QuÃmica e Bioatividade / Staurosporines from Eudistoma vannamei: Chemistry and Bioactivity.
Eudistoma vannamei (Millar, 1977) Ã uma ascÃdia endÃmica do litoral do Nordeste brasileiro, largamente encontrado nas praias rochosas do estado do CearÃ. Previamente, o extrato bruto apresentou um interessante perfil em termos de bioatividade. O fracionamento bioguiado identificou uma mistura 1:1 altamente citotÃxica, contendo dois derivados inÃditos d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/07/2009
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10. Investigação da susceptibilidade de formas sanguíneas do plasmodium falciparum à apoptose frente a estímulos com óxido nítrico, cloroquina e estaurosporina. / Inquiry of the susceptibility of sanguineous forms of plasmodium falciparum to apoptosis front the stimulatons with nitric oxide, choloroquine and staurosporine.
It is known that antibodies, nitric oxide and chloroquine inhibit P. falciparum growth, even though the mechanism of parasite death was never clearly elucidated. In the studies where parasite culture was used to access cell death in presence of antiparasite compounds, apoptosis was only investigated on the basis of DNA fragmentation using electrophoresis gel
Publicado em: 2006
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11. Interruption of the blood-stage cycle of the malaria parasite, Plasmodium chabaudi, by protein tyrosine kinase inhibitors
Malaria is a devastating disease caused by a unicellular protozoan, Plasmodium, which affects 3.7 million people every year. Resistance of the parasite to classical treatments such as chloroquine requires the development of new drugs. To gain insight into the mechanisms that control Plasmodium cell cycle, we have examined the effects of kinase inhibitors on
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-11
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12. The effect of an HIV-1 viral protease inhibitor on staurosporine-induced apoptosis in immortalized mesangial cells
CONTEXTO: A glomeruloesclerose progressiva (GEP) é uma situação caracterizada pela acumulação de matriz extracelular glomerular e pela diminuição no número de células no glomérulo. Os mecanismos envolvidos na perda progressiva do número glomerular da célula não são bem compreendidos, mas podem envolver o processo da apoptose. Os principais medi
Sao Paulo Medical Journal. Publicado em: 02/05/2002