Spontaneous Calcium Events
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. SÃndrome das pernas inquietas em pacientes com insuficiÃncia renal crÃnica e em sujeitos sem doenÃa renal: um estudo comparativo / Restless Legs Syndrome in patients with CRF and in subjects who had no renal disease reported: a clinical comparative study
Purpose: To determine the frequency and the clinical characteristics of restless legs syndrome (RLS) in patients with chronic renal failure (CRF) and in a control group. Subjects and method: Two hundred fifty-two individuals were evaluated at random, 123 from the group of patients with CRF, and 129 from the control group. They were evaluated by means of a st
Publicado em: 2007
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2. Estudo das bases mecanísticas da diferenciação neuronal mediada pela atividade de Ca2+ através dos receptores purinérgicos e colinérgicos / Study of mechanistic bases of neuronal differentiation mediated by Ca2+ activity through purinergic and cholinergic receptors
Muitos subtipos de receptores são ativados pelo mesmo ligante, mas estão acoplados a diferentes mensageiros secundários podendo produzir sinalização divergente em uma célula, enquanto receptores ativados por diferentes ligantes, mas que compartilham o mesmo mensageiro secundário, podem produzir sinalização convergente. Para examinar as bases mecaní
Publicado em: 2007
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3. Calcium Dynamics of Cortical Astrocytic Networks In Vivo
Large and long-lasting cytosolic calcium surges in astrocytes have been described in cultured cells and acute slice preparations. The mechanisms that give rise to these calcium events have been extensively studied in vitro. However, their existence and functions in the intact brain are unknown. We have topically applied Fluo-4 AM on the cerebral cortex of an
Public Library of Science.
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4. Effects of synapsin I and calcium/calmodulin-dependent protein kinase II on spontaneous neurotransmitter release in the squid giant synapse.
The molecular events that control synaptic vesicle availability in chemical synaptic junctions have not been fully clarified. Among the protein molecules specifically located in presynaptic terminals, synapsin I and calcium/calmodulin-dependent protein kinase II (CaM kinase II) have been shown to modulate evoked transmitter release in the squid giant synapse
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5. Variability in frequency and characteristics of Ca2+ sparks at different release sites in rat ventricular myocytes.
1. High spatial resolution confocal imaging was used to investigate spontaneous calcium release events (Ca2+ sparks) in isolated rat cardiac myocytes loaded with the fluorescent calcium indicator fluo-3. 2. Frequencies of sparks at different release sites varied widely, with a few sites showing sustained activities as great as 50 times the average. Sites wit
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6. Dynamics of dendritic calcium transients evoked by quantal release at excitatory hippocampal synapses
Synaptic N-methyl-d-aspartate (NMDA) receptors detect coincident pre- and postsynaptic activity and play a critical role in triggering changes in synaptic strength at central synapses. Despite intensive study of synaptic plasticity, relatively little is known about the magnitude and duration of calcium accumulation caused by unitary events at individual syna
The National Academy of Sciences.
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7. Spontaneous calcium release in tissue from the failing canine heart
Abnormalities in calcium handling have been implicated as a significant source of electrical instability in heart failure (HF). While these abnormalities have been investigated extensively in isolated myocytes, how they manifest at the tissue level and trigger arrhythmias is not clear. We hypothesize that in HF, triggered activity (TA) is due to spontaneous
American Physiological Society.
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8. Partial depletion of sarcoplasmic reticulum calcium does not prevent calcium sparks in rat ventricular myocytes.
1. The exact nature of calcium sparks in the heart remains highly controversial. We sought to determine whether calcium sparks arise from a single or multiple calcium release channels/ ryanodine receptors in the sarcoplasmic reticulum (SR). If their genesis involves a calcium-coupled recruitment of multiple channels, calcium sparks might be abolished by a mo
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9. Nonlinear propagation of spherical calcium waves in rat cardiac myocytes.
Spontaneous calcium waves in enzymatically isolated rat cardiac myocytes were investigated by confocal laser scanning microscopy (CLSM) using the fluorescent Ca2+-indicator fluo-3 AM. As recently shown, a spreading wave of enhanced cytosolic calcium appears, most probably during Ca2+ overload, and is initiated by an elementary event called a "calcium spark."
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10. Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations
Oscillations in intracellular free calcium concentration ([Ca2+]i) occur spontaneously in immature neurons of the developing cerebral cortex. Here, we show that developing murine cortical neurons exhibit calcium oscillations in response to direct activation of the mGluR5 subtype of the group I metabotropic glutamate receptor (mGluR). In contrast, other manip
The National Academy of Sciences.
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11. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes.
1. Confocal microfluorometry was used to study the effects of tetracaine on spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) in isolated rat ventricular myocytes. 2. At low concentrations (0.25-1.25 mM), tetracaine caused an initial inhibition of spontaneous release events (Ca2+ sparks) and Ca2+ waves, which was followed by a gradual increase in
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12. Spontaneous and evoked intracellular calcium transients in donor-derived myocytes following intracardiac myoblast transplantation
Skeletal myoblast transplantation is a potential treatment for congestive heart failure. To study the functional activity of both donor and host myocytes following transplantation, skeletal myoblasts expressing an enhanced green fluorescent protein (EGFP) transgene were transplanted into hearts of nontransgenic recipients, and changes in intracellular calciu
American Society for Clinical Investigation.