Splenic Architecture
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Avaliação quantitativa e qualitativa das alterações no tecido esplênico de camundongos esquistossomóticos e dislipidêmicos / Quantitative and qualitative assessment of changes in splenic tissue of mice with schistossomiasis and dyslipidemic
Neste estudo, investigamos a organização qualitativa e quantitativa do tecido esplênico na fase aguda (nona semana) da infecção pelo Schistosoma mansoni em camundongos Swiss alimentados com uma dieta hipercolesterolêmica (29% lipídios) ou uma ração padrão (12% de lipídios). O volume do baço foi medido pelo método de Scherle. Os cortes histológi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2012
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2. SubpopulaÃÃes de linfÃcitos CD4, CD8 e CD45RB em enxertos esplÃnicos autÃlogos heterotÃpicos de camundongos sadios e esquistossomÃticos: estudo comparativo com o baÃo intacto e o remanescente esplÃnico vascularizado
Schistosomiasis mansoni is an infectious disease caused by a worm (Schistosoma mansoni), which has the human as one of the definitive hosts in its evolutive course. In more advanced stages, massive embolization by eggs layed in the portal venous sistems by adult forms of the parasite to the hepatic parenchima occurs; this leads to inflammatory reactions in t
Publicado em: 2004
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3. Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-β receptor–IgG1 fusion protein
Early in ontogeny, the secondary lymphoid organs become populated with numerous cells of mesodermal origin which forms both the lymphoid and stromal elements. The critical receptor/ligand interactions necessary for lymphoid organogenesis to occur are for the most part unknown. Although lymphotoxin-α (LTα) has been shown to be required for normal lymph
The National Academy of Sciences of the USA.
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4. Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway
Reticular networks in lymphoid organs play critical roles in the organization of local microenvironments. A number of these elements are maintained by continual signaling through the lymphotoxin system. Evaluation of the lymphotoxin (LT) pathway in primates using a fusion protein decoy provides a unique opportunity to assess modulation of splenic microenviro
American Society for Clinical Investigation.
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5. Lymphotoxin-α-Deficient Mice Can Clear a Productive Infection with Murine Gammaherpesvirus 68 but Fail To Develop Splenomegaly or Lymphocytosis†
Respiratory challenge with murine gammaherpesvirus 68 (MHV-68) leads to an acute productive infection of the lung and a persistent latent infection in B lymphocytes, epithelia, and macrophages. The virus also induces splenomegaly and an increase in the number of activated CD8 T cells in the circulation. Lymphotoxin- α-deficient (LTα−/−) mice have no ly
American Society for Microbiology.
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6. Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice
The tumor necrosis factor (TNF) family cytokines lymphotoxin (LT) α and LTβ form heterotrimers that are expressed on the surface of activated lymphocytes and natural killer cells; LTα homotrimers can be secreted as well. Mice with a disrupted LTα gene lack lymph nodes (LN), Peyer’s patches (PP), and follicular dendritic cell (FDC) networks and reveal p
The National Academy of Sciences of the USA.
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7. Critical roles for IFN-β in lymphoid development, myelopoiesis, and tumor development: Links to tumor necrosis factor α
We have generated mice null for IFN-β and report the diverse consequences of IFN-β for both the innate and adaptive arms of immunity. Despite no abnormalities in the proportional balance of CD4 and CD8 T cell populations in the peripheral blood, thymus, and spleen of IFN-β-/- mice, activated lymph node and splenic T lymphocytes exhibit enhanced T cell pro
National Academy of Sciences.
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8. Chromatin Architecture near a Potential 3′ End of the Igh Locus Involves Modular Regulation of Histone Modifications during B-Cell Development and In Vivo Occupancy at CTCF Sites
The murine Igh locus has a 3′ regulatory region (3′ RR) containing four enhancers (hs3A, hs1,2, hs3B, and hs4) at DNase I-hypersensitive sites. The 3′ RR exerts long-range effects on class switch recombination (CSR) to several isotypes through its control of germ line transcription. By measuring levels of acetylated histones H3 and H4 and of dimethylat
American Society for Microbiology.
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9. Murine malaria: blood clearance and organ sequestration of Plasmodium yoelii-infected erythrocytes.
This study examined the mechanisms of clearance of Plasmodium yoelii-infected erythrocytes (RBC) from the peripheral circulation of mice. Parasitized RBC labeled with 51Cr were cleared from the blood of normal C57BL/6 mice at a much more rapid rate than were nonparasitized RBC, and preincubation of parasitized RBC in antiplasmodial antibody failed to signifi
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10. The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells
Transcription factors NF-κB1 and c-Rel, individually dispensable during embryogenesis, serve similar, yet distinct, roles in the function of mature hemopoietic cells. Redundancy among Rel/NF-κB family members prompted an examination of the combined roles of c-Rel and NF-κB1 by using mice that lack both proteins. Embryonic development and the maturation of
The National Academy of Sciences.
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11. B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses
B-cell maturation protein (BCMA) is a member of the tumor necrosis factor (TNF) receptor family and is expressed in B lymphocytes. BCMA binds two TNF family members, BAFF and APRIL, that stimulate cellular proliferation. BAFF in particular has been shown to influence B-cell survival and activation, and transgenic mice overexpressing BAFF have a lupus-like au
American Society for Microbiology.
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12. Pathological changes in the spleens of gamma interferon receptor-deficient mice infected with murine gammaherpesvirus: a role for CD8 T cells.
Murine gammaherpesvirus is a natural rodent pathogen which causes a primary infection in the lungs and establishes a persistent infection in B lymphocytes. During the primary infection, large amounts of gamma interferon (IFN-gamma) are produced by spleen, mediastinal, and cervical lymph node cells. To investigate the role of IFN-gamma in control of the virus