Splenic Architecture
Mostrando 13-14 de 14 artigos, teses e dissertações.
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13. NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue
Targeted disruption of the transcription factor NKX2.3 gene in mice results in anatomical defects of intestine and secondary lymphoid organs. Here, we report that spleen and Peyer’s patches of NKX2.3-deficient mice are considerably reduced in size and lack the ordered tissue architecture. T and B cells are misplaced within the spleen and mesenteric lymph
Oxford University Press.
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14. In vitro immune responses to a T cell-dependent antigen by cultures of disassociated murine Peyer's patch
The first line of defense against pathogens that enter the host by the oral route appears to involve the gut-associated lymphoreticular tissue—e.g., Peyer's patches (PP). Although animals can readily be immunized by orally administered antigen that mobilizes the secretory immune system, there is a total lack of local antibody synthesis in the PP and the ce