Silencing
Mostrando 1-12 de 1529 artigos, teses e dissertações.
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1. A germline-targeted genetic screen for xrn-2 suppressors identifies a novel gene C34C12.2 in Caenorhabditis elegans
Abstract XRN2 is an evolutionarily conserved 5’-to-3’ exoribonuclease, which degrades or trims various types of RNA in the nucleus. Although XRN-2 is essential for embryogenesis, larval development and reproduction in Caenorhabditis elegans, relevant molecular pathways remain unidentified. Here we create a germline-specific xrn-2 conditional mutant and p
Genetics and Molecular Biology. Publicado em: 2023
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2. Gene Silencing Therapeutics in Cardiology: A Review Article
Abstract Therapeutics that inhibit enzymes, receptors, ion channels, and cotransporters have long been the mainstay of cardiovascular medicine. Now, oligonucleotide therapeutics offer a modern variation on this paradigm of protein inhibition. Rather than target a protein, however, small interfering ribonucleic acids and antisense oligonucleotides target the
International Journal of Cardiovascular Sciences. Publicado em: 2022
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3. The Protective Effect of Kaempferol Against Ischemia/Reperfusion Injury Through Activating SIRT3 to Inhibit Oxidative Stress
Abstract Introduction: The objective of this study is to investigate the protective effect of kaempferol against ischemia/reperfusion (IR) injury and the underlying molecular mechanisms. Methods: H9C2 cells were pretreated with kaempferol for 24 hours and further insulted with IR injury. Cell vitality, reactive oxygen species (ROS) level, glutathione (GSH)
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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4. Long non-coding RNA HOTAIR induces the PI3K/AKT/mTOR signaling pathway in breast cancer cells
SUMMARY OBJECTIVE: The phosphoinositide 3-kinase/protein kinase AKT/mammalian target of rapamycin signaling pathway is essential for proper cellular metabolism and cell growth. However, aberrant activation of this pathway has been linked to the progression and metastasis of breast cancer. Recently, the role of long non-coding RNAs in interfering with the ce
Revista da Associação Médica Brasileira. Publicado em: 2022
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5. Analysis of the Gene Expression and RNAi-Mediated Knockdown of Chitin Synthase from Leaf-Cutting Ant Atta sexdens
Chitin synthase (CHS) is the enzyme specifically associated with chitin synthesis, an important component of diverse organisms including insects. Two alternative spliced transcripts of the CHS gene (AsCHS-A1 and AsCHS-A2) were identified by quantitative reverse-transcription polymerase chain reaction (RT-qPCR) during the development of the leaf-cutting ant A
J. Braz. Chem. Soc.. Publicado em: 2020-10
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6. Silences in media coverage of the World Cup in Pernambuco, Brazil
Abstract The 2014 World Cup occurred in Brazil at a time of great political turbulence and change in communications markets. From the standpoint of a person involved in media coverage of this championship, the MA thesis titled Os silêncios, os silenciamentos e a cobertura midiática da Copa do Mundo em Pernambuco (Silences, silencing and media coverage of t
Sociologias. Publicado em: 2020-04
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7. The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway
The aim of this study was to investigate the role of kinase-insert domain-containing receptor (KDR) in intrauterine adhesions (IUA) and its mechanism. The Case group consisted of 92 patients diagnosed with IUA, and the Control group included 86 patients with uterine septum who had normal endometrium verified with an uteroscope. In addition, 50 rats were rand
Braz J Med Biol Res. Publicado em: 07/10/2019
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8. O currículo e suas implicações nas relações sociais de gênero entre estudantes do ensino fundamental
Resumo: Este artigo apresenta resultados da pesquisa intitulada O currículo e suas implicações nas relações sociais de gênero entre estudantes do ensino fundamental. Trata-se de um artigo original, derivado da investigação que objetivou compreender as implicações do currículo escolar na construção das relações de gênero entre estudantes do en
Rev. Bras. Estud. Pedagog.. Publicado em: 12/09/2019
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9. O corpo negado pela sua “extrema subjetividade”: expressões da colonialidade do saber na ética em pesquisa
Buscando compreender as (in)visibilidade dos corpos não heteronormativos na educação médica, a qual sistematicamente sustenta seus discursos institucionais baseados na coerência biológica, olhei para o meu corpo gay , de médico e de professor, para compreender essa cultura e seus desdobramentos. O objetivo deste trabalho é discutir os enfrentamos ins
Interface (Botucatu). Publicado em: 19/08/2019
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10. MiR-106a aggravates sepsis-induced acute kidney injury by targeting THBS2 in mice model
Abstract Purpose To investigate the role and related mechanisms of miR-106a in sepsis-induced AKI. Methods Serum from sepsis and healthy patients was collected, sepsis mouse model was established by cecal ligation and puncture (CLP). TCMK-1 cells were treated with lipopolysaccharide (LPS) and transfected with THBS2-small interfering RNA (siTHBS2), miR-10
Acta Cir. Bras.. Publicado em: 19/08/2019
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11. Ca2+/Calmodulin-dependent kinase II delta B is essential for cardiomyocyte hypertrophy and complement gene expression after LPS and HSP60 stimulation in vitro
Inflammation plays an important role in the development of cardiovascular diseases (CVDs), suggesting that the immune system is a target of therapeutic interventions used for treating CVDs. This study evaluated mechanisms underlying inflammatory response and cardiomyocyte hypertrophy associated with bacterial lipopolysaccharide (LPS)- or heat shock protein 6
Braz J Med Biol Res. Publicado em: 15/07/2019
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12. Discursos sobre o cuidado em saúde de Lésbicas, Gays, Bissexuais, Travestis, Transexuais (LGBT) entre médicas(os) da Estratégia Saúde da Família
Objetiva-se identificar os discursos sobre o acesso e a qualidade da atenção integral à saúde da população de Lésbicas, Gays, Bissexuais, Travestis e Transexuais (LGBT) entre médicas(os) da Estratégia Saúde da Família, refletindo sobre como esses discursos podem impactar o cuidado em saúde da população LGBT. Participaram 15 médicas(os) em Uber
Interface (Botucatu). Publicado em: 10/07/2019