Sickle Cell Anemia Complications
Mostrando 1-12 de 22 artigos, teses e dissertações.
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1. Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle cell anemia patients
ABSTRACT Introduction Mutations affecting genes involved in oxidative and signaling pathways may be associated with kidney disease in sickle cell anemia. We determined the allele and genotype frequencies of some polymorphisms in the promoter regions of the Heme Oxygenase-1 (HMOX1) [rs2071746 (A > T) and (GT)n repeats, short (S) and long (L) alleles] and Bon
Hematol., Transfus. Cell Ther.. Publicado em: 2021-06
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2. Predictors associated with sickle cell nephropathy: a systematic review
SUMMARY INTRODUCTION: Sickle cell anemia affects more than 30 million people worldwide. Chronic kidney disease develops in 40% of individuals. The death rate of patients with sickle nephropathy is still high, with little known predictors related to its development. To answer the question “What predictors are associated with the onset of chronic kidney dis
Rev. Assoc. Med. Bras.. Publicado em: 2021-02
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3. Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
ABSTRACT Sickle cell anemia (SCA) is a common genetic blood disorder, affecting millions worldwide. According to current evidence, individuals with SCA have more than 300 times greater risk to develop bacterial meningitis (BM) than the general population. Herein we have described the characteristics of a series of BM cases in SCA patients in Salvador, Brazil
Hematol., Transfus. Cell Ther.. Publicado em: 2020-06
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4. Aortic Valve Replacement Combined with Ascending Aortic Aneurysmectomy in a Patient with Sickle Cell Disease: a Case Report
Abstract Sickle cell anemia is a haematological disorder characterized by multiple vaso-occlusive complications, resulting in a reduced life expectancy. These patients are exposed to several triggering factors for sickle cell crises when they are submitted to cardiovascular surgeries with extracorporeal circulation. Therefore, meticulous care and perioperati
Braz. J. Cardiovasc. Surg.. Publicado em: 2018-04
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5. Comprehensive neuropsychological evaluation of children and adolescents with sickle cell anemia: a hospital-based sample
Abstract Background: Individuals with sickle cell anemia may suffer symptomatic or silent cerebral infarcts leading to neurocognitive complications. This study investigated the cognitive and intellectual performance of children and adolescents with sickle cell anemia. Methods: The socioeconomic status, clinical aspects and behavioral profile of 15 young in
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-03
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6. Cholelithiasis and its complications in sickle cell disease in a university hospital
Abstract Introduction: The clinical manifestations of sickle cell disease are related to the polymerization of hemoglobin S. The chronic hemolysis caused by this condition often causes the formation of gallstones that can migrate and block the common bile duct leading to acute abdomen. Objective: This study aimed to evaluate the profile of patients with si
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-03
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7. Clinical and laboratory profile of patients with sickle cell anemia
Abstract Objective: This study aimed to describe and analyze clinical and laboratory characteristics of patients with sickle cell anemia treated at the Hemominas Foundation, in Divinópolis, Brazil. Furthermore, this study aimed to compare the clinical and laboratory outcomes of the group of patients treated with hydroxyurea with those patients that were no
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-03
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8. Prevalence of glutathione S-transferase gene deletions and their effect on sickle cell patients
BACKGROUND: Glutathione S-transferase gene deletions are known detoxification agents and cause oxidative damage. Due to the different pathophysiology of anemia in thalassemia and sickle cell disease, there are significant differences in the pathophysiology of iron overload and iron-related complications in these disorders. OBJECTIVE: The aim of this study wa
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2012
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9. A model of genetic guidance for hemoglobinopathy patients and laboratory diagnosis of family members as educational and preventive measures
BACKGROUND: The high frequency of hemoglobinopathies in Brazil constitutes a public health problem and thus educational and preventive measures are necessary to reduce the incidence. Genetic guidance, a modality of genetic counseling, and family screening are measures that can assist in reproductive decisions and mitigate clinical, psychological and social p
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012
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10. Avaliação funcional dos eosinófilos na anemia falciforme e o efeito do tratamento com hidroxiureia / Altered functional properties of eosinophils in sickle cell anemia and effects of hydroxyurea therapy
Sickle cell anemia is the homozygous state for hemoglobin S. Inflammation plays an important role in the vaso-occlusive process of the disease, where leukocytes, proinflammatory cytokines and adhesion molecules are increased in the peripheral blood of patients with sickle cell anemia. Leukocytosis is associated with morbidity and mortality in these patients.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/05/2011
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11. Duffy Genotype and Clinical Manifestations Severity in Sickle Cell Anemia / Genótipo Duffy e Gravidade das Manifestações Clínicas na Anemia Falciforme
INTRODUCTION: Sickle cell anemia (SCA) presents with large clinical variability and previous studies suggest that genetic polymorphisms may act as complications predictors. The Duffy antigen appears to play an important role in the removal of inflammatory chemokines from the circulation, suggesting that Duffy-Negative individuals have lower clearance of cyto
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/03/2011
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12. Prevalence of sickle cell disease and sickle cell trait in national neonatal screening studies
Sickle cell anemia is the best known hereditary blood disorder; there are serious complications associated with the condition. Diagnosis and early intervention reduce morbidity and mortality. These benefits have resulted in the widespread use of newborn screening education programs. In Brazil, the National Neonatal Screening Program established by decree 822
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-02